Antiviral immune response is usually coordinated by IFN-type cytokines that activate cells and intensify the response against these invading agents, triggered by the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs), such as toll-like receptors (TLR), fundamental for pathogen recognition and activation of innate immunity. Type 7 of TLR (TLR7) – expressed on the surface of endosomes predominantly in the lungs, placenta, and spleen – might play a central role in COVID-19. This receptor has been reported to quickly recognize single-stranded SARS-CoV-1 RNA, inducing the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-12 in plasmacytoid dendritic cells (141–143).