thelium, which expresses ACE2 and TMPRSS2, allowing access to the central nervous system (CNS). The spread of the virus through the hematogenous or transsynaptic pathway has also been widely discussed, however, it is known that the different levels of neurotropism and neurovirulence in patients with COVID-19 can be explained by a combination of viral factors and their interaction with the host (41, 92, 93).
Regarding the evolution of infected individuals, aging