Once the viral genome is inside the host cell cytoplasm, translation of viral RNA produces RNA-dependent RNA polymerase (RdRp), which uses viral RNA as a template to generate virus-specific mRNAs (subgenomic mRNAs) from subgenomic negative-strand intermediates (64–66). Translation of subgenomic mRNAs leads to the production of structural and nonstructural viral proteins. Thus, after their formation, structural proteins are inserted into the membrane of the endoplasmic reticulum or Golgi, and viral particles germinate into the endoplasmic reticulum-Golgi intermediate compartment. Finally, the vesicles containing the virus particles fuse with the plasma membrane to release the virus (65, 67, 68).