of immunomodulation and immune evasion will be discussed in the subsequent topics. Figure 1 Genetic evolution of SARS-CoV-2 and its consequences. Compared with other β-CoVs, SARS-CoV-2 has similarities of 50, 79, and 88 - 96% to MERS-CoV, SARS-CoV-1, and bat SARS-like-CoV genome, respectively, with 91% similarity with SARS-li