Such genomic changes also affected the recognition of these viruses by immune cells. Baruah and Bose (40) demonstrated that Sars-CoV-2 has specific regions for B cell and cytotoxic T cell glycoproteins recognition, which does not coincide with those found in bat-derived CoV, SARS-CoV-1, or MERS-CoV ( Figure 1 ). Such distinguished interaction of cells and viruses can promote unusual immunomodulation or immune responses that contribute to the severity of the disease. All aspects of immunomodulation and immune evasion will be discussed in the subsequent topics.