ritional approach could be used to enhance the immune system’s response to obesity in patients affected by COVID-19, focusing on the interplay between immunonutrition, inflammation and gut microbiota. Immune system, inflammation and COVID-19 The immune system protects the human body from infections by a series of pathogen (bacteria, viruses, fungi, parasites) [5]. A self-tolerance system prevents the immune response from damaging human tissues. The immune system is always active, carrying