In the current pandemic panorama, the connection between nutrition science and virology takes a predictable turn. It is worth that nutritional innovation must correlate all the previously treated clinical aspects. By referring to WHO guidelines, it is fundamental to follow healthy eating habits and lifestyle to achieve an optimal health status supporting immune cells system, and to switch from an unhealthy condition of dysbiosis to a healthy condition of eubiosis and modulating systemic inflammation. This is essentially possible pursuing a balanced diet based on the Mediterranean concept and staying physically active.