It seems interesting the possibility to improve the action of adiponectin through diet intervention. A healthy lifestyle and a Mediterranean diet seem to ameliorate adiponectin levels in human, working on omega-3 biochemical pathways [51]. Finally, in light of the above, a possible COVID-19 therapy would combine drug therapy with a personalized immunonutrition [48]. Whereas healthy adipose tissue is essential to achieve a metabolic health status, sick inflamed fat leads to metabolic pathways dysregulation and different chronic pathologies [52].