Adipose tissue is not only part of the endocrine system, but it is an active immune organ [40]. As an organ suitable to manage the adaptive and innate immune responses, in healthy lean individuals, its immune cells have the main role in the formation of extracellular matrix modelling, insulin sensitivity, adipogenesis, angiogenesis and clearance of apoptotic adipocytes. On the contrary, during the expansion of adipose tissue like in obesity, inflammation results in adipocyte hypertrophy, cell death, fibrosis and metabolic dysfunction. The inflammatory process, involving both innate and adaptive immune cells, plays an important role in adipose immunometabolism. Among those, macrophages are fundamental for adipose tissue homeostasis and are most thoroughly studied in response to obesity [41].