Table 1  Clinical characteristics of critically ill COVID‐19‐infected patients with putative invasive pulmonary aspergillosis
Patient 1  Patient 2  Patient 3  Patient 4
Age (y)  82  79  77  77
Gender  Male  Male  Male  Male
Comorbid conditions
Hypertension  No  Yes  No  No
Diabetes  No  No  No  Yes
Coronary artery disease  No  Yes  No  No
Chronic obstructive pulmonary disease  Yes  No  No  No
History of cerebrovascular accident  No  Yes  No  No
History of cancer  Yes  Yes  No  No
Dementia  No  No  No  No
Timing of positive culture for Aspergillus fumigatus (hospital day)  Day 15 and 20  Day 7, 10, and 16  Day 10 and 14  Day 10
Clinical features at Aspergillus isolation
Fever  No  No  Yes  No
Respiratory status at Aspergillus isolation  IMV  IMV  IMV  IMV
New radiographic abnormalities on chest CT or X‐ray  Worsening infiltrates  Opacities with dense consolidations  Cavitary pneumonia  Diffuse interstitial and patchy hazy opacities
White blood cell count (103/μL)  32.9  21.1  20.1  20.2
Platelet count (103/μL)  376  146  420  123
Procalcitonin (ng/mL)  0.16  0.30  3.30  9.34
Lactic acid (mmol/L)  1.0  3.6  1.6  3.7
Total bilirubin (mg/dL)  2.4  1.1  1.4  2.9
Serum creatinine (mg/dL)  2.6  3.1  1.5  4.1
Serum galactomannan  NA  0.71  Negative  Negative
Vasopressor support  Yes  Yes  Yes  Yes
Inpatient medications
Glucocorticoids
Cumulative dose in prednisone equivalent (mg)  932  1000  870  87
Starting date (hospital day)  Day 8  Day 2  Day 2  Day 10
Duration (d)  10  10  12  3
Tocilizumab  No  Yes  No  No
Antibiotics  Cefepime + Vancomycin  Cefepime + Vancomycin  Meropenem + Vancomycin  Cefepime + Vancomycin
Antifungal therapy  Voriconazole  Voriconazole  Voriconazole  Caspofungin
Abbreviations: IMV, invasive mechanical ventilation; NA, not available.
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