There is mounting evidence for preformed immunity against the novel coronavirus SARS-CoV-216,19–22. Reports on memory T cell response to the endemic coronaviruses are lacking, but since antibody titers appear transient and frequent re-infections cannot be excluded28–31, it is probable that the endemic coronaviruses with low virulence do not create lasting immunity. This then begs the question, which pathogen can generate a memory T cell response cross-reactive to SARS-CoV-2. Through in silico analysis of predicted SARS-CoV-2 epitopes and common pathogens we address this question.