rged as a robust quantitative proteomics technique for the comprehensive analysis of differentially expressed proteins (DEPs). To date, this technique has been successfully applied to numerous studies involved in virus-host interactions, examples of which include TGEV,22 PEDV,24 foot-and-mouth disease virus (FMDV),25 porcine circovirus type 2 (PCV2), and classical swine fever virus (CSFV).26 These studies have given a good overview of the dynamic interactions between the virus and its host, and provide important clues for a better understanding of the viral pathogenesis.