pathway, which is involved in six proteins AKT2, BNIP3, PDK1, WDR24, TMEM55B, and COL4A1; the immune system pathway, which is involved in four proteins ISG15, IFIT1, OAS1 and IFIT3; the digestive system pathway, which is involved in four proteins AKT2, MT-2A, COL4A1, and cystatin C; and the cancer pathway, which is involved in four proteins PDK1, AKT2, COL4A1, and CDK9. Once again, we found that the same protein can participate in different signaling pathways. For instance, ISG15, a IFN-α-inducible protein that is paramount to the host antiviral innate immunity,48 was simultaneo