he third exists independently. For the two tightly connected networks, they were comprised of two groups of strongly interacted proteins, including SCGN-ISG15-OAS1-IFIT1-IFIT3-ANAPC7-NME7, which are associated with innate immunity, and POLDIP3-NUP37-ERCC6L-DDX55-SMARCA2-NFRB-BAZ2A-HLTF-CHAF1A-CDK9-MNAT1-CTDP1-INTS4, which are associated with cell cycle and cellular components. Of note, at least five proteins act as hub proteins in these two networks tightly connected, including IFIT1, IFIT3, NUP37, SMARCA2, and CDK9. Interestingly, MNAT1 interacted highly with CTDP1 and CDK9, and INTS4 was also well connected to CDK9 (Figure 6). For the third network, there were five proteins with strong interaction in response to PDC