Porcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the U.S. in 2014.3 Since then, the virus has been detected in many other countries, including Canada, mainland China, South Korea, Thailand, Laos, Vietnam, Japan, Mexico, and so on.4,5 Clinically, PDCoV-infected pigs often present with diarrhea and/or vomiting, dehydration, and death of neonatal piglets.6 The outbreak of PDCoV infection in numerous countries has resulted in considerable economic losses to the global swine industry.7