in humans besides the recognition of numerous coronavirus strains in bats, including SARS-CoVs, imply the future continues zoonotic transmission events (Anthony et al., 2017; Ge et al., 2013; Zhou et al., 2020). In addition to an extremely pathogenic strains of CoV; MERS-CoV, SARS-CoV and SARS-CoV-2, belonging to same genus (b-coronavirus), four other low-pathogenic endemic strains in humans are also reported: HCoV-229E, HCoVHKU1, HCoV-NL63 and HCoV-OC43.Till date, no vaccines