Glide Standard-Precision (SP) docking was performed and the best binding ligand to ACE2 was observed to be α-hederin (-6.265 kcal/mol), Thymohydroquinone (-5.466 kcal/mol) and Thymoquinone (-5.048 kcal/mol) (Table 4). Their binding energies were good and therefore, these compounds can be looked further to use them as future therapeutics. The docking poses of best binding compounds are displayed in Figure 3(a–c).