ACE2 alone has various functions related to blood-vessel dilation, controlling blood pressure, cytokine production, inflammatory response, and protein transport. The initial symptoms of breathlessness, dysregulated blood pressure and inflammation are the ones which are reported initially in COVID-19 diagnosis. The next receptors downstream in this signaling event are IL6, AKT1, VEGFA, INS, IGF1, etc. (Figure 1(b)).