Polyphenols in propolis activated PI3K and AMPK signaling pathways and promoted GLUT4 translocation in L6 myotubes though only kaempferide increased glucose uptake.Propolis extract (In vitro, 1 μg) and In vivo significantly promoted the phosphorylation of IR, PI3K, and AMPK and increased GLUT4 translocation in rat skeletal muscle and subsequently decreased postprandial blood glucose levels. Propolis extract had no effect on α-glucosidase activity in the small intestine.