In vitroA single oral dose of Brazilian propolis extract (250 mg/kg body weight)In vivoArtepillin C, coumaric acid, and kaempferide (1–104 ng/mL for 15 min)  In vitroDifferentiated L6 myoblast cells isolated from ratsIn vivo5-weeks old male ICR mice  EGs: artepillin C, coumaric acid, and kaempferide (1, 10 μM), and propolis (1–104 ng/mL)CG1: insulin (100 nM)CG2: AICARCG3: DMSO  2-Deoxyglucose uptake, OGTT, maltase and sucrase-isomaltase activities in epithelial cells of the small intestinal, phosphorylation of AMPK, PI3K, AKT, AS160, IR, and GLUT4 translocation.  Polyphenols in propolis activated PI3K and AMPK signaling pathways and promoted GLUT4 translocation in L6 myotubes though only kaempferide increased glucose uptake.Propolis extract (In vitro, 1 μg) and In vivo significantly promoted the phosphorylation of IR, PI3K, and AMPK and increased GLUT4 translocation in rat skeletal muscle and subsequently decreased postprandial blood glucose levels. Propolis extract had no effect on α-glucosidase activity in the small intestine.  [70]