PMC:7601109 / 95568-96178 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Brazilian propolis extract (100 μg/mL/4-12 h) In vitroDifferentiated myoblast C2C12 cells and RAW264 macrophages isolated from mice EGs: propolis (100 μg/mL)CG1: ethanol (0.008%)CG2: DMSO (0.08%).CG3: IKK inhibitor (BMS-345541) IL-6, LIF, CCL-2, CCL-5, CXCL-10, VEGF-A, COX2, MMP-12, migration of RAW264 macrophages, and activities of MAIL/IκBζ and NF-κB. Propolis (at 8h) induced RAW264 macrophage migration, activated MAIL/IκBζ and NF-κB proteins p50 and p65, and increased levels of VEGF-A, COX-2, MMP-12, CCL-2, CCL-5, CCL-10, LIF, and IL-6. Propolis inhibited the production of IL-1β and TNF-α. [108]","divisions":[{"label":"td","span":{"begin":0,"end":45}},{"label":"td","span":{"begin":47,"end":132}},{"label":"td","span":{"begin":134,"end":229}},{"label":"td","span":{"begin":231,"end":358}},{"label":"td","span":{"begin":360,"end":603}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T848","span":{"begin":70,"end":78},"obj":"Body_part"},{"id":"T849","span":{"begin":85,"end":90},"obj":"Body_part"},{"id":"T850","span":{"begin":102,"end":113},"obj":"Body_part"},{"id":"T851","span":{"begin":231,"end":233},"obj":"Body_part"},{"id":"T852","span":{"begin":307,"end":318},"obj":"Body_part"},{"id":"T853","span":{"begin":392,"end":402},"obj":"Body_part"},{"id":"T854","span":{"begin":444,"end":452},"obj":"Body_part"},{"id":"T855","span":{"begin":544,"end":546},"obj":"Body_part"},{"id":"T856","span":{"begin":587,"end":591},"obj":"Body_part"},{"id":"T857","span":{"begin":587,"end":589},"obj":"Body_part"}],"attributes":[{"id":"A848","pred":"fma_id","subj":"T848","obj":"http://purl.org/sig/ont/fma/fma70335"},{"id":"A849","pred":"fma_id","subj":"T849","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A850","pred":"fma_id","subj":"T850","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A851","pred":"fma_id","subj":"T851","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A852","pred":"fma_id","subj":"T852","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A853","pred":"fma_id","subj":"T853","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A854","pred":"fma_id","subj":"T854","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A855","pred":"fma_id","subj":"T855","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A856","pred":"fma_id","subj":"T856","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A857","pred":"fma_id","subj":"T857","obj":"http://purl.org/sig/ont/fma/fma86578"},{"subj":"T848","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T849","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T850","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T851","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T852","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T853","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T854","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T855","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T856","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T857","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T156","span":{"begin":218,"end":221},"obj":"Disease"}],"attributes":[{"id":"A156","pred":"mondo_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/MONDO_0006687"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T91021","span":{"begin":38,"end":42},"obj":"http://purl.obolibrary.org/obo/CLO_0001360"},{"id":"T1707","span":{"begin":79,"end":90},"obj":"http://purl.obolibrary.org/obo/CLO_0052295"},{"id":"T1708","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0008752"},{"id":"T1709","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0051424"},{"id":"T1710","span":{"begin":270,"end":271},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1711","span":{"begin":300,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0008752"},{"id":"T1712","span":{"begin":300,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0051424"},{"id":"T1713","span":{"begin":324,"end":334},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1714","span":{"begin":345,"end":346},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1715","span":{"begin":356,"end":357},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1716","span":{"begin":385,"end":391},"obj":"http://purl.obolibrary.org/obo/CLO_0008752"},{"id":"T1717","span":{"begin":385,"end":391},"obj":"http://purl.obolibrary.org/obo/CLO_0051424"},{"id":"T1718","span":{"begin":414,"end":423},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1719","span":{"begin":431,"end":432},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1720","span":{"begin":442,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T1721","span":{"begin":495,"end":496},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T91021","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1707","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1708","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1709","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1710","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1711","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1712","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1713","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1714","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1715","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1716","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1717","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1718","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1719","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1720","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1721","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T43286","span":{"begin":10,"end":26},"obj":"Chemical"},{"id":"T33051","span":{"begin":164,"end":171},"obj":"Chemical"},{"id":"T48815","span":{"begin":185,"end":189},"obj":"Chemical"},{"id":"T53998","span":{"begin":203,"end":216},"obj":"Chemical"},{"id":"T28834","span":{"begin":207,"end":216},"obj":"Chemical"},{"id":"T40502","span":{"begin":231,"end":233},"obj":"Chemical"},{"id":"T538","span":{"begin":242,"end":245},"obj":"Chemical"},{"id":"T95389","span":{"begin":249,"end":252},"obj":"Chemical"},{"id":"T45043","span":{"begin":279,"end":282},"obj":"Chemical"},{"id":"T72156","span":{"begin":352,"end":354},"obj":"Chemical"},{"id":"T90074","span":{"begin":438,"end":440},"obj":"Chemical"},{"id":"T49798","span":{"begin":444,"end":452},"obj":"Chemical"},{"id":"T32037","span":{"begin":505,"end":508},"obj":"Chemical"},{"id":"T31369","span":{"begin":513,"end":516},"obj":"Chemical"},{"id":"T93574","span":{"begin":520,"end":523},"obj":"Chemical"},{"id":"T62417","span":{"begin":527,"end":530},"obj":"Chemical"},{"id":"T87765","span":{"begin":544,"end":546},"obj":"Chemical"},{"id":"T55922","span":{"begin":587,"end":589},"obj":"Chemical"}],"attributes":[{"id":"A61030","pred":"chebi_id","subj":"T43286","obj":"http://purl.obolibrary.org/obo/CHEBI_83162"},{"id":"A54148","pred":"chebi_id","subj":"T33051","obj":"http://purl.obolibrary.org/obo/CHEBI_16236"},{"id":"A22515","pred":"chebi_id","subj":"T48815","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A63764","pred":"chebi_id","subj":"T53998","obj":"http://purl.obolibrary.org/obo/CHEBI_77113"},{"id":"A47090","pred":"chebi_id","subj":"T28834","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A43972","pred":"chebi_id","subj":"T40502","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A7819","pred":"chebi_id","subj":"T40502","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A77272","pred":"chebi_id","subj":"T538","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A23946","pred":"chebi_id","subj":"T95389","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A99401","pred":"chebi_id","subj":"T45043","obj":"http://purl.obolibrary.org/obo/CHEBI_340824"},{"id":"A71458","pred":"chebi_id","subj":"T45043","obj":"http://purl.obolibrary.org/obo/CHEBI_59761"},{"id":"A5935","pred":"chebi_id","subj":"T72156","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A2964","pred":"chebi_id","subj":"T72156","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A30814","pred":"chebi_id","subj":"T72156","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A28854","pred":"chebi_id","subj":"T90074","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A25218","pred":"chebi_id","subj":"T90074","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A31757","pred":"chebi_id","subj":"T90074","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A68170","pred":"chebi_id","subj":"T49798","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A63501","pred":"chebi_id","subj":"T32037","obj":"http://purl.obolibrary.org/obo/CHEBI_340824"},{"id":"A2781","pred":"chebi_id","subj":"T32037","obj":"http://purl.obolibrary.org/obo/CHEBI_59761"},{"id":"A45098","pred":"chebi_id","subj":"T31369","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A85867","pred":"chebi_id","subj":"T93574","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A28250","pred":"chebi_id","subj":"T62417","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A11911","pred":"chebi_id","subj":"T87765","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A25468","pred":"chebi_id","subj":"T87765","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A49553","pred":"chebi_id","subj":"T55922","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A5651","pred":"chebi_id","subj":"T55922","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T43286","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33051","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48815","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53998","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28834","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40502","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T538","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T95389","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45043","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T72156","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T90074","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T49798","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32037","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31369","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T93574","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T62417","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87765","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T55922","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T460","span":{"begin":392,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_1905517"}],"attributes":[{"subj":"T460","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T597","span":{"begin":0,"end":358},"obj":"Sentence"},{"id":"T598","span":{"begin":360,"end":549},"obj":"Sentence"},{"id":"T599","span":{"begin":550,"end":610},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T597","pred":"source","obj":"LitCovid-sentences"},{"subj":"T598","pred":"source","obj":"LitCovid-sentences"},{"subj":"T599","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2807","span":{"begin":231,"end":235},"obj":"Gene"},{"id":"2808","span":{"begin":237,"end":240},"obj":"Gene"},{"id":"2809","span":{"begin":242,"end":247},"obj":"Gene"},{"id":"2810","span":{"begin":249,"end":254},"obj":"Gene"},{"id":"2811","span":{"begin":256,"end":263},"obj":"Gene"},{"id":"2812","span":{"begin":265,"end":271},"obj":"Gene"},{"id":"2813","span":{"begin":273,"end":277},"obj":"Gene"},{"id":"2814","span":{"begin":279,"end":285},"obj":"Gene"},{"id":"2815","span":{"begin":352,"end":357},"obj":"Gene"},{"id":"2816","span":{"begin":438,"end":443},"obj":"Gene"},{"id":"2817","span":{"begin":461,"end":464},"obj":"Gene"},{"id":"2818","span":{"begin":490,"end":496},"obj":"Gene"},{"id":"2819","span":{"begin":498,"end":503},"obj":"Gene"},{"id":"2820","span":{"begin":505,"end":511},"obj":"Gene"},{"id":"2821","span":{"begin":513,"end":518},"obj":"Gene"},{"id":"2822","span":{"begin":520,"end":525},"obj":"Gene"},{"id":"2823","span":{"begin":535,"end":538},"obj":"Gene"},{"id":"2824","span":{"begin":544,"end":548},"obj":"Gene"},{"id":"2825","span":{"begin":587,"end":592},"obj":"Gene"},{"id":"2826","span":{"begin":597,"end":602},"obj":"Gene"},{"id":"2886","span":{"begin":159,"end":162},"obj":"Gene"},{"id":"2927","span":{"begin":128,"end":132},"obj":"Species"},{"id":"3053","span":{"begin":95,"end":101},"obj":"CellLine"},{"id":"3054","span":{"begin":300,"end":306},"obj":"CellLine"},{"id":"3055","span":{"begin":385,"end":391},"obj":"CellLine"}],"attributes":[{"id":"A2807","pred":"tao:has_database_id","subj":"2807","obj":"Gene:16193"},{"id":"A2808","pred":"tao:has_database_id","subj":"2808","obj":"Gene:16878"},{"id":"A2809","pred":"tao:has_database_id","subj":"2809","obj":"Gene:20296"},{"id":"A2810","pred":"tao:has_database_id","subj":"2810","obj":"Gene:20304"},{"id":"A2811","pred":"tao:has_database_id","subj":"2811","obj":"Gene:15945"},{"id":"A2812","pred":"tao:has_database_id","subj":"2812","obj":"Gene:22339"},{"id":"A2813","pred":"tao:has_database_id","subj":"2813","obj":"Gene:17709"},{"id":"A2814","pred":"tao:has_database_id","subj":"2814","obj":"Gene:17381"},{"id":"A2815","pred":"tao:has_database_id","subj":"2815","obj":"Gene:18033"},{"id":"A2816","pred":"tao:has_database_id","subj":"2816","obj":"Gene:18033"},{"id":"A2817","pred":"tao:has_database_id","subj":"2817","obj":"Gene:25716"},{"id":"A2818","pred":"tao:has_database_id","subj":"2818","obj":"Gene:22339"},{"id":"A2819","pred":"tao:has_database_id","subj":"2819","obj":"Gene:19225"},{"id":"A2820","pred":"tao:has_database_id","subj":"2820","obj":"Gene:17381"},{"id":"A2821","pred":"tao:has_database_id","subj":"2821","obj":"Gene:20296"},{"id":"A2822","pred":"tao:has_database_id","subj":"2822","obj":"Gene:20304"},{"id":"A2823","pred":"tao:has_database_id","subj":"2823","obj":"Gene:16878"},{"id":"A2824","pred":"tao:has_database_id","subj":"2824","obj":"Gene:16193"},{"id":"A2825","pred":"tao:has_database_id","subj":"2825","obj":"Gene:16175"},{"id":"A2826","pred":"tao:has_database_id","subj":"2826","obj":"Gene:24835"},{"id":"A2886","pred":"tao:has_database_id","subj":"2886","obj":"Gene:231042"},{"id":"A2927","pred":"tao:has_database_id","subj":"2927","obj":"Tax:10090"},{"id":"A3053","pred":"tao:has_database_id","subj":"3053","obj":"CVCL:4478"},{"id":"A3054","pred":"tao:has_database_id","subj":"3054","obj":"CVCL:4478"},{"id":"A3055","pred":"tao:has_database_id","subj":"3055","obj":"CVCL:4478"},{"subj":"2807","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2808","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2809","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2810","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2811","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2812","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2813","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2814","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2815","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2816","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2817","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2818","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2819","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2820","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2821","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2822","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2823","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2824","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2825","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2826","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2886","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2927","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3053","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3054","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3055","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93c5","default":true},{"id":"LitCovid-PD-MONDO","color":"#93dfec"},{"id":"LitCovid-PD-CLO","color":"#ecdf93"},{"id":"LitCovid-PD-CHEBI","color":"#c593ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ecaa"},{"id":"LitCovid-sentences","color":"#ec9395"},{"id":"LitCovid-PubTator","color":"#93afec"}]}]}}