PMC:7601109 / 92230-93154 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Dietary royal jelly and pRJ + MF powder diet (0.05% or 0.5%) 6-months old male HET mouse model of severe sarcopenia (background strains: BALB/c, C57BL/6, C3H, and DBA/2) EG1 and EG2: HET mice on 0.05% and 0.5% royal jelly, respectivelyEG3 and EG4: HET mice on 0.05% and 0.5% pRJ, respectivelyCG1: untreated HET miceCG2: untreated young mice No of blood cells and Pax7 SC, albumin, AST, ALT, T-CHO, TG, expression of muscle genes (MyoD, myogenein, myostatin) and catabolic genes (E3 ubiquitin ligases MuRF1, and atrogin-1). Behavioral tests: grip strength, wire hang, rotarod, and horizontal bar tests. RJ and pRJ significantly delayed age-related impairment of motor functions, positively improved physical performance of treated mice in 4 types of tests (grip strength, wire hang, horizontal bar, and rotarod), lowered age-related muscular atrophy, increased No of Pax7 SC markers, and suppressed catabolic genes. 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