EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice