PMC:7601109 / 75607-78058 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"The relation between muscle mass or strength and physical function in old people is not as direct or clear as originally presumed. Existing knowledge indicates that muscle strength may be intact in people with muscle loss. Likewise, decreased muscle strength may not necessarily alter physical performance [21,170]. Research notes that selection of interventions that merely increase muscle mass and/or strength entails ignoring valuable therapies that contribute to various biological processes of muscle recovery by interfering with pathologies conducive to muscle loss. More, combining functional measures of muscle performance with different comprehensive biomarkers (e.g., of metabolism, inflammation, oxidative stress, etc.) in skeletal muscle and the whole body may identify therapies that can positively affect muscle qualities independent of mass increase [21]. In support of this argument, treating sarcopenic elderly with oral amino acids (which represent only one ingredient of royal jelly or bee pollen) significantly increased whole-body lean mass 6 and 18 months after treatment as indicated by dual-energy X-ray absorptiometry. This effect was attributed to enhancement of insulin sensitivity and anabolism as portrayed by significant reductions in fasting blood glucose, serum insulin, HOMA-IR, and serum tumor necrosis factor-α (TNF-α) as well as increase of serum level of IGF-1 and IGF-1/TNF-α ratio [171]. Animal studies lend further support to those reports. For instance, royal jelly had no effect on muscle differentiation genes (myogenic differentiation 1 (MyoD), myogenein, myostatin) in sarcopenic mice, indicating that royal jelly may not improve age-related deterioration of muscle strength—once it occurs. On the other hand, royal jelly significantly reduced the progression of muscle atrophy by decreasing the expression of catabolism genes E3 ubiquitin ligases MuRF1 and atrogin-1 in old mice to levels similar to those in young mice [97]. Royal jelly also stimulated the differentiation of satellite stem cells both in vivo and in vitro and improved the regenerative capacity of injured muscle [96,97]. Therefore, royal jelly treatment might reduce the progression of age-related muscular atrophy [59]. Future RCTs that evaluate the effect of bee products on muscle qualities and motor performance in humans should be properly designed to include biological markers of motor functioning along with behavioral measures.","tracks":[{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T149","span":{"begin":1273,"end":1278},"obj":"Body_part"},{"id":"T150","span":{"begin":1288,"end":1293},"obj":"Body_part"},{"id":"T151","span":{"begin":1316,"end":1321},"obj":"Body_part"},{"id":"T152","span":{"begin":1377,"end":1382},"obj":"Body_part"},{"id":"T153","span":{"begin":1749,"end":1753},"obj":"Body_part"}],"attributes":[{"id":"A149","pred":"uberon_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A151","pred":"uberon_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A152","pred":"uberon_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A153","pred":"uberon_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T655","span":{"begin":21,"end":27},"obj":"Body_part"},{"id":"T656","span":{"begin":165,"end":171},"obj":"Body_part"},{"id":"T657","span":{"begin":210,"end":216},"obj":"Body_part"},{"id":"T658","span":{"begin":243,"end":249},"obj":"Body_part"},{"id":"T659","span":{"begin":384,"end":390},"obj":"Body_part"},{"id":"T660","span":{"begin":499,"end":505},"obj":"Body_part"},{"id":"T661","span":{"begin":560,"end":566},"obj":"Body_part"},{"id":"T662","span":{"begin":612,"end":618},"obj":"Body_part"},{"id":"T663","span":{"begin":743,"end":749},"obj":"Body_part"},{"id":"T664","span":{"begin":764,"end":768},"obj":"Body_part"},{"id":"T665","span":{"begin":819,"end":825},"obj":"Body_part"},{"id":"T666","span":{"begin":938,"end":949},"obj":"Body_part"},{"id":"T667","span":{"begin":1047,"end":1051},"obj":"Body_part"},{"id":"T668","span":{"begin":1189,"end":1196},"obj":"Body_part"},{"id":"T669","span":{"begin":1273,"end":1278},"obj":"Body_part"},{"id":"T670","span":{"begin":1279,"end":1286},"obj":"Body_part"},{"id":"T671","span":{"begin":1288,"end":1293},"obj":"Body_part"},{"id":"T672","span":{"begin":1294,"end":1301},"obj":"Body_part"},{"id":"T673","span":{"begin":1316,"end":1321},"obj":"Body_part"},{"id":"T674","span":{"begin":1377,"end":1382},"obj":"Body_part"},{"id":"T675","span":{"begin":1524,"end":1530},"obj":"Body_part"},{"id":"T676","span":{"begin":1704,"end":1710},"obj":"Body_part"},{"id":"T677","span":{"begin":1749,"end":1753},"obj":"Body_part"},{"id":"T678","span":{"begin":1808,"end":1814},"obj":"Body_part"},{"id":"T679","span":{"begin":2033,"end":2043},"obj":"Body_part"},{"id":"T680","span":{"begin":2038,"end":2043},"obj":"Body_part"},{"id":"T681","span":{"begin":2120,"end":2126},"obj":"Body_part"},{"id":"T682","span":{"begin":2292,"end":2298},"obj":"Body_part"}],"attributes":[{"id":"A655","pred":"fma_id","subj":"T655","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A656","pred":"fma_id","subj":"T656","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A657","pred":"fma_id","subj":"T657","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A658","pred":"fma_id","subj":"T658","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A659","pred":"fma_id","subj":"T659","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A660","pred":"fma_id","subj":"T660","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A661","pred":"fma_id","subj":"T661","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A662","pred":"fma_id","subj":"T662","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A663","pred":"fma_id","subj":"T663","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A664","pred":"fma_id","subj":"T664","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A665","pred":"fma_id","subj":"T665","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A666","pred":"fma_id","subj":"T666","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A667","pred":"fma_id","subj":"T667","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A668","pred":"fma_id","subj":"T668","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A669","pred":"fma_id","subj":"T669","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A670","pred":"fma_id","subj":"T670","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A671","pred":"fma_id","subj":"T671","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A672","pred":"fma_id","subj":"T672","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A673","pred":"fma_id","subj":"T673","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A674","pred":"fma_id","subj":"T674","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A675","pred":"fma_id","subj":"T675","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A676","pred":"fma_id","subj":"T676","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A677","pred":"fma_id","subj":"T677","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A678","pred":"fma_id","subj":"T678","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A679","pred":"fma_id","subj":"T679","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A680","pred":"fma_id","subj":"T680","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A681","pred":"fma_id","subj":"T681","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A682","pred":"fma_id","subj":"T682","obj":"http://purl.org/sig/ont/fma/fma32558"},{"subj":"T655","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T656","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T657","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T658","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T659","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T660","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T661","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T662","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T663","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T664","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T665","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T666","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T667","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T668","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T669","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T670","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T671","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T672","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T673","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T674","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T675","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T676","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T677","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T678","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T679","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T680","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T681","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T682","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T132","span":{"begin":693,"end":705},"obj":"Disease"},{"id":"T133","span":{"begin":1322,"end":1327},"obj":"Disease"},{"id":"T134","span":{"begin":2213,"end":2229},"obj":"Disease"}],"attributes":[{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0005070"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0004323"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T133","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T134","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1298","span":{"begin":21,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1299","span":{"begin":21,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1300","span":{"begin":21,"end":27},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1301","span":{"begin":21,"end":27},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1302","span":{"begin":165,"end":171},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1303","span":{"begin":165,"end":171},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1304","span":{"begin":165,"end":171},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1305","span":{"begin":165,"end":171},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1306","span":{"begin":210,"end":216},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1307","span":{"begin":210,"end":216},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1308","span":{"begin":210,"end":216},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1309","span":{"begin":210,"end":216},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1310","span":{"begin":243,"end":249},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1311","span":{"begin":243,"end":249},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1312","span":{"begin":243,"end":249},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1313","span":{"begin":243,"end":249},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1314","span":{"begin":384,"end":390},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1315","span":{"begin":384,"end":390},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1316","span":{"begin":384,"end":390},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1317","span":{"begin":384,"end":390},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1318","span":{"begin":499,"end":505},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1319","span":{"begin":499,"end":505},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1320","span":{"begin":499,"end":505},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1321","span":{"begin":499,"end":505},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1322","span":{"begin":560,"end":566},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1323","span":{"begin":560,"end":566},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1324","span":{"begin":560,"end":566},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1325","span":{"begin":560,"end":566},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1326","span":{"begin":612,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1327","span":{"begin":612,"end":618},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1328","span":{"begin":612,"end":618},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1329","span":{"begin":612,"end":618},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1330","span":{"begin":734,"end":749},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T1331","span":{"begin":734,"end":749},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T1332","span":{"begin":734,"end":749},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T1333","span":{"begin":758,"end":768},"obj":"http://purl.obolibrary.org/obo/UBERON_0013702"},{"id":"T1334","span":{"begin":819,"end":825},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1335","span":{"begin":819,"end":825},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1336","span":{"begin":819,"end":825},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1337","span":{"begin":819,"end":825},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1338","span":{"begin":1041,"end":1051},"obj":"http://purl.obolibrary.org/obo/UBERON_0013702"},{"id":"T1339","span":{"begin":1068,"end":1070},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T1340","span":{"begin":1189,"end":1196},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T1341","span":{"begin":1273,"end":1278},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T1342","span":{"begin":1273,"end":1278},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T1343","span":{"begin":1294,"end":1301},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T1344","span":{"begin":1308,"end":1310},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T1345","span":{"begin":1427,"end":1433},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T1346","span":{"begin":1524,"end":1530},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1347","span":{"begin":1524,"end":1530},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1348","span":{"begin":1524,"end":1530},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1349","span":{"begin":1524,"end":1530},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1350","span":{"begin":1547,"end":1552},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1351","span":{"begin":1704,"end":1710},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1352","span":{"begin":1704,"end":1710},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1353","span":{"begin":1704,"end":1710},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1354","span":{"begin":1704,"end":1710},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1355","span":{"begin":1808,"end":1814},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1356","span":{"begin":1808,"end":1814},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1357","span":{"begin":1808,"end":1814},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1358","span":{"begin":1808,"end":1814},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1359","span":{"begin":1866,"end":1871},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T1360","span":{"begin":1872,"end":1874},"obj":"http://purl.obolibrary.org/obo/CLO_0002861"},{"id":"T1361","span":{"begin":2033,"end":2043},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T1362","span":{"begin":2120,"end":2126},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1363","span":{"begin":2120,"end":2126},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1364","span":{"begin":2120,"end":2126},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1365","span":{"begin":2120,"end":2126},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1366","span":{"begin":2292,"end":2298},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1367","span":{"begin":2292,"end":2298},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1368","span":{"begin":2292,"end":2298},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1369","span":{"begin":2292,"end":2298},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1370","span":{"begin":2334,"end":2340},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"attributes":[{"subj":"T1298","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1299","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1300","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1301","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1302","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1303","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1304","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1305","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1306","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1307","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1308","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1309","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1310","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1312","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1313","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1314","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1315","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1316","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1317","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1318","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1319","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1320","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1321","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1322","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1323","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1324","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1325","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1326","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1327","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1328","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1329","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1330","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1331","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1332","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1333","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1334","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1336","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1337","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1338","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1339","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1340","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1341","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1342","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1343","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1345","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1346","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1347","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1348","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1349","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1350","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1351","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1352","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1353","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1354","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1355","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1356","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1357","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1358","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1359","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1360","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1361","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1362","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1363","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1364","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1365","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1366","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1367","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1368","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1369","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1370","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T36546","span":{"begin":938,"end":949},"obj":"Chemical"},{"id":"T98595","span":{"begin":938,"end":943},"obj":"Chemical"},{"id":"T275","span":{"begin":944,"end":949},"obj":"Chemical"},{"id":"T69550","span":{"begin":990,"end":1001},"obj":"Chemical"},{"id":"T93322","span":{"begin":1189,"end":1196},"obj":"Chemical"},{"id":"T83603","span":{"begin":1279,"end":1286},"obj":"Chemical"},{"id":"T98924","span":{"begin":1294,"end":1301},"obj":"Chemical"},{"id":"T87849","span":{"begin":1308,"end":1310},"obj":"Chemical"},{"id":"T282","span":{"begin":1495,"end":1506},"obj":"Chemical"},{"id":"T18914","span":{"begin":1647,"end":1658},"obj":"Chemical"},{"id":"T82129","span":{"begin":1755,"end":1766},"obj":"Chemical"},{"id":"T34876","span":{"begin":2147,"end":2158},"obj":"Chemical"}],"attributes":[{"id":"A58954","pred":"chebi_id","subj":"T36546","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A29196","pred":"chebi_id","subj":"T98595","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A31991","pred":"chebi_id","subj":"T275","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A18752","pred":"chebi_id","subj":"T69550","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A47085","pred":"chebi_id","subj":"T93322","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A48027","pred":"chebi_id","subj":"T83603","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A11228","pred":"chebi_id","subj":"T83603","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A90117","pred":"chebi_id","subj":"T98924","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A86947","pred":"chebi_id","subj":"T87849","obj":"http://purl.obolibrary.org/obo/CHEBI_74061"},{"id":"A35339","pred":"chebi_id","subj":"T282","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A85739","pred":"chebi_id","subj":"T18914","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A66488","pred":"chebi_id","subj":"T82129","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A87192","pred":"chebi_id","subj":"T34876","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"subj":"T36546","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98595","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69550","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T93322","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T83603","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98924","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T87849","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T18914","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34876","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T365","span":{"begin":681,"end":691},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T366","span":{"begin":693,"end":705},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T367","span":{"begin":1213,"end":1222},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T368","span":{"begin":1328,"end":1336},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T369","span":{"begin":1328,"end":1336},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T370","span":{"begin":1328,"end":1336},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T371","span":{"begin":1328,"end":1336},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T372","span":{"begin":1808,"end":1822},"obj":"http://purl.obolibrary.org/obo/GO_0014889"},{"id":"T373","span":{"begin":1855,"end":1865},"obj":"http://purl.obolibrary.org/obo/GO_0009056"}],"attributes":[{"subj":"T365","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T366","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T367","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T368","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T369","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T370","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T371","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T372","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T373","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T79","span":{"begin":707,"end":723},"obj":"Phenotype"},{"id":"T80","span":{"begin":1322,"end":1327},"obj":"Phenotype"},{"id":"T81","span":{"begin":1808,"end":1822},"obj":"Phenotype"},{"id":"T82","span":{"begin":2213,"end":2229},"obj":"Phenotype"}],"attributes":[{"id":"A79","pred":"hp_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/HP_0025464"},{"id":"A80","pred":"hp_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"A81","pred":"hp_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/HP_0003202"},{"id":"A82","pred":"hp_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/HP_0003202"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T446","span":{"begin":0,"end":130},"obj":"Sentence"},{"id":"T447","span":{"begin":131,"end":222},"obj":"Sentence"},{"id":"T448","span":{"begin":223,"end":315},"obj":"Sentence"},{"id":"T449","span":{"begin":316,"end":572},"obj":"Sentence"},{"id":"T450","span":{"begin":573,"end":870},"obj":"Sentence"},{"id":"T451","span":{"begin":871,"end":1143},"obj":"Sentence"},{"id":"T452","span":{"begin":1144,"end":1426},"obj":"Sentence"},{"id":"T453","span":{"begin":1427,"end":1480},"obj":"Sentence"},{"id":"T454","span":{"begin":1481,"end":1735},"obj":"Sentence"},{"id":"T455","span":{"begin":1736,"end":1971},"obj":"Sentence"},{"id":"T456","span":{"begin":1972,"end":2135},"obj":"Sentence"},{"id":"T457","span":{"begin":2136,"end":2235},"obj":"Sentence"},{"id":"T458","span":{"begin":2236,"end":2451},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T446","pred":"source","obj":"LitCovid-sentences"},{"subj":"T447","pred":"source","obj":"LitCovid-sentences"},{"subj":"T448","pred":"source","obj":"LitCovid-sentences"},{"subj":"T449","pred":"source","obj":"LitCovid-sentences"},{"subj":"T450","pred":"source","obj":"LitCovid-sentences"},{"subj":"T451","pred":"source","obj":"LitCovid-sentences"},{"subj":"T452","pred":"source","obj":"LitCovid-sentences"},{"subj":"T453","pred":"source","obj":"LitCovid-sentences"},{"subj":"T454","pred":"source","obj":"LitCovid-sentences"},{"subj":"T455","pred":"source","obj":"LitCovid-sentences"},{"subj":"T456","pred":"source","obj":"LitCovid-sentences"},{"subj":"T457","pred":"source","obj":"LitCovid-sentences"},{"subj":"T458","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1706","span":{"begin":1189,"end":1196},"obj":"Gene"},{"id":"1707","span":{"begin":1294,"end":1301},"obj":"Gene"},{"id":"1708","span":{"begin":1322,"end":1345},"obj":"Gene"},{"id":"1709","span":{"begin":1347,"end":1352},"obj":"Gene"},{"id":"1710","span":{"begin":1392,"end":1397},"obj":"Gene"},{"id":"1711","span":{"begin":1402,"end":1407},"obj":"Gene"},{"id":"1712","span":{"begin":1408,"end":1413},"obj":"Gene"},{"id":"1713","span":{"begin":1554,"end":1580},"obj":"Gene"},{"id":"1714","span":{"begin":1582,"end":1586},"obj":"Gene"},{"id":"1715","span":{"begin":1893,"end":1898},"obj":"Gene"},{"id":"1716","span":{"begin":1903,"end":1912},"obj":"Gene"},{"id":"1717","span":{"begin":1600,"end":1609},"obj":"Gene"},{"id":"1718","span":{"begin":74,"end":80},"obj":"Species"},{"id":"1719","span":{"begin":198,"end":204},"obj":"Species"},{"id":"1720","span":{"begin":1625,"end":1629},"obj":"Species"},{"id":"1721","span":{"begin":1920,"end":1924},"obj":"Species"},{"id":"1722","span":{"begin":1961,"end":1965},"obj":"Species"},{"id":"1723","span":{"begin":2334,"end":2340},"obj":"Species"},{"id":"1724","span":{"begin":2201,"end":2204},"obj":"Gene"},{"id":"1725","span":{"begin":1675,"end":1678},"obj":"Gene"},{"id":"1726","span":{"begin":1279,"end":1286},"obj":"Chemical"},{"id":"1727","span":{"begin":1972,"end":1983},"obj":"Chemical"},{"id":"1728","span":{"begin":2147,"end":2158},"obj":"Chemical"},{"id":"1729","span":{"begin":210,"end":221},"obj":"Disease"},{"id":"1730","span":{"begin":560,"end":571},"obj":"Disease"},{"id":"1731","span":{"begin":693,"end":705},"obj":"Disease"},{"id":"1732","span":{"begin":1808,"end":1822},"obj":"Disease"},{"id":"1733","span":{"begin":2222,"end":2229},"obj":"Disease"}],"attributes":[{"id":"A1706","pred":"tao:has_database_id","subj":"1706","obj":"Gene:3630"},{"id":"A1707","pred":"tao:has_database_id","subj":"1707","obj":"Gene:3630"},{"id":"A1708","pred":"tao:has_database_id","subj":"1708","obj":"Gene:24835"},{"id":"A1709","pred":"tao:has_database_id","subj":"1709","obj":"Gene:24835"},{"id":"A1710","pred":"tao:has_database_id","subj":"1710","obj":"Gene:24482"},{"id":"A1711","pred":"tao:has_database_id","subj":"1711","obj":"Gene:24482"},{"id":"A1712","pred":"tao:has_database_id","subj":"1712","obj":"Gene:24835"},{"id":"A1713","pred":"tao:has_database_id","subj":"1713","obj":"Gene:17927"},{"id":"A1714","pred":"tao:has_database_id","subj":"1714","obj":"Gene:17927"},{"id":"A1715","pred":"tao:has_database_id","subj":"1715","obj":"Gene:433766"},{"id":"A1716","pred":"tao:has_database_id","subj":"1716","obj":"Gene:67731"},{"id":"A1717","pred":"tao:has_database_id","subj":"1717","obj":"Gene:17700"},{"id":"A1718","pred":"tao:has_database_id","subj":"1718","obj":"Tax:9606"},{"id":"A1719","pred":"tao:has_database_id","subj":"1719","obj":"Tax:9606"},{"id":"A1720","pred":"tao:has_database_id","subj":"1720","obj":"Tax:10090"},{"id":"A1721","pred":"tao:has_database_id","subj":"1721","obj":"Tax:10090"},{"id":"A1722","pred":"tao:has_database_id","subj":"1722","obj":"Tax:10090"},{"id":"A1723","pred":"tao:has_database_id","subj":"1723","obj":"Tax:9606"},{"id":"A1724","pred":"tao:has_database_id","subj":"1724","obj":"Gene:81759"},{"id":"A1725","pred":"tao:has_database_id","subj":"1725","obj":"Gene:81759"},{"id":"A1726","pred":"tao:has_database_id","subj":"1726","obj":"MESH:D005947"},{"id":"A1727","pred":"tao:has_database_id","subj":"1727","obj":"MESH:C058787"},{"id":"A1728","pred":"tao:has_database_id","subj":"1728","obj":"MESH:C058787"},{"id":"A1729","pred":"tao:has_database_id","subj":"1729","obj":"MESH:D009135"},{"id":"A1730","pred":"tao:has_database_id","subj":"1730","obj":"MESH:D009135"},{"id":"A1731","pred":"tao:has_database_id","subj":"1731","obj":"MESH:D007249"},{"id":"A1732","pred":"tao:has_database_id","subj":"1732","obj":"MESH:D009133"},{"id":"A1733","pred":"tao:has_database_id","subj":"1733","obj":"MESH:D001284"},{"subj":"1706","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1707","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1708","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1709","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1710","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1711","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1712","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1713","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1714","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1715","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1716","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1717","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1718","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1719","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1720","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1721","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1722","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1723","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1724","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1725","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1726","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1727","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1728","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1729","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1730","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1731","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1732","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1733","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-UBERON","color":"#93a3ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#bdec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93d7"},{"id":"LitCovid-PD-CLO","color":"#93ece7"},{"id":"LitCovid-PD-CHEBI","color":"#eccd93"},{"id":"LitCovid-PD-GO-BP","color":"#b393ec"},{"id":"LitCovid-PD-HP","color":"#93ec99"},{"id":"LitCovid-sentences","color":"#ec93a6"},{"id":"LitCovid-PubTator","color":"#93c0ec"}]}]}}