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PMC:7601109 / 75607-78058 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T149 1273-1278 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T150 1288-1293 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T151 1316-1321 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T152 1377-1382 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T153 1749-1753 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T655 21-27 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T656 165-171 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T657 210-216 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T658 243-249 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T659 384-390 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T660 499-505 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T661 560-566 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T662 612-618 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T663 743-749 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T664 764-768 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T665 819-825 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T666 938-949 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T667 1047-1051 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T668 1189-1196 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T669 1273-1278 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T670 1279-1286 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T671 1288-1293 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T672 1294-1301 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T673 1316-1321 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T674 1377-1382 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T675 1524-1530 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T676 1704-1710 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T677 1749-1753 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T678 1808-1814 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T679 2033-2043 Body_part denotes stem cells http://purl.org/sig/ont/fma/fma63368
T680 2038-2043 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T681 2120-2126 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T682 2292-2298 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T132 693-705 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T133 1322-1327 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T134 2213-2229 Disease denotes muscular atrophy http://purl.obolibrary.org/obo/MONDO_0004323

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1298 21-27 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1299 21-27 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1300 21-27 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1301 21-27 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1302 165-171 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1303 165-171 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1304 165-171 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1305 165-171 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1306 210-216 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1307 210-216 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1308 210-216 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1309 210-216 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1310 243-249 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1311 243-249 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1312 243-249 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1313 243-249 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1314 384-390 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1315 384-390 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1316 384-390 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1317 384-390 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1318 499-505 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1319 499-505 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1320 499-505 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1321 499-505 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1322 560-566 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1323 560-566 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1324 560-566 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1325 560-566 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1326 612-618 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1327 612-618 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1328 612-618 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1329 612-618 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1330 734-749 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1331 734-749 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1332 734-749 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1333 758-768 http://purl.obolibrary.org/obo/UBERON_0013702 denotes whole body
T1334 819-825 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1335 819-825 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1336 819-825 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1337 819-825 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1338 1041-1051 http://purl.obolibrary.org/obo/UBERON_0013702 denotes whole-body
T1339 1068-1070 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T1340 1189-1196 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1341 1273-1278 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1342 1273-1278 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T1343 1294-1301 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1344 1308-1310 http://purl.obolibrary.org/obo/PR_000009064 denotes IR
T1345 1427-1433 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes Animal
T1346 1524-1530 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1347 1524-1530 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1348 1524-1530 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1349 1524-1530 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1350 1547-1552 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T1351 1704-1710 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1352 1704-1710 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1353 1704-1710 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1354 1704-1710 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1355 1808-1814 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1356 1808-1814 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1357 1808-1814 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1358 1808-1814 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1359 1866-1871 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T1360 1872-1874 http://purl.obolibrary.org/obo/CLO_0002861 denotes E3
T1361 2033-2043 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T1362 2120-2126 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1363 2120-2126 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1364 2120-2126 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1365 2120-2126 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1366 2292-2298 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1367 2292-2298 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1368 2292-2298 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1369 2292-2298 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1370 2334-2340 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T36546 938-949 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T98595 938-943 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T275 944-949 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T69550 990-1001 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T93322 1189-1196 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T83603 1279-1286 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T98924 1294-1301 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T87849 1308-1310 Chemical denotes IR http://purl.obolibrary.org/obo/CHEBI_74061
T282 1495-1506 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T18914 1647-1658 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T82129 1755-1766 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T34876 2147-2158 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T365 681-691 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T366 693-705 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T367 1213-1222 http://purl.obolibrary.org/obo/GO_0009058 denotes anabolism
T368 1328-1336 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T369 1328-1336 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T370 1328-1336 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T371 1328-1336 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T372 1808-1822 http://purl.obolibrary.org/obo/GO_0014889 denotes muscle atrophy
T373 1855-1865 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T79 707-723 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T80 1322-1327 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T81 1808-1822 Phenotype denotes muscle atrophy http://purl.obolibrary.org/obo/HP_0003202
T82 2213-2229 Phenotype denotes muscular atrophy http://purl.obolibrary.org/obo/HP_0003202

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T446 0-130 Sentence denotes The relation between muscle mass or strength and physical function in old people is not as direct or clear as originally presumed.
T447 131-222 Sentence denotes Existing knowledge indicates that muscle strength may be intact in people with muscle loss.
T448 223-315 Sentence denotes Likewise, decreased muscle strength may not necessarily alter physical performance [21,170].
T449 316-572 Sentence denotes Research notes that selection of interventions that merely increase muscle mass and/or strength entails ignoring valuable therapies that contribute to various biological processes of muscle recovery by interfering with pathologies conducive to muscle loss.
T450 573-870 Sentence denotes More, combining functional measures of muscle performance with different comprehensive biomarkers (e.g., of metabolism, inflammation, oxidative stress, etc.) in skeletal muscle and the whole body may identify therapies that can positively affect muscle qualities independent of mass increase [21].
T451 871-1143 Sentence denotes In support of this argument, treating sarcopenic elderly with oral amino acids (which represent only one ingredient of royal jelly or bee pollen) significantly increased whole-body lean mass 6 and 18 months after treatment as indicated by dual-energy X-ray absorptiometry.
T452 1144-1426 Sentence denotes This effect was attributed to enhancement of insulin sensitivity and anabolism as portrayed by significant reductions in fasting blood glucose, serum insulin, HOMA-IR, and serum tumor necrosis factor-α (TNF-α) as well as increase of serum level of IGF-1 and IGF-1/TNF-α ratio [171].
T453 1427-1480 Sentence denotes Animal studies lend further support to those reports.
T454 1481-1735 Sentence denotes For instance, royal jelly had no effect on muscle differentiation genes (myogenic differentiation 1 (MyoD), myogenein, myostatin) in sarcopenic mice, indicating that royal jelly may not improve age-related deterioration of muscle strength—once it occurs.
T455 1736-1971 Sentence denotes On the other hand, royal jelly significantly reduced the progression of muscle atrophy by decreasing the expression of catabolism genes E3 ubiquitin ligases MuRF1 and atrogin-1 in old mice to levels similar to those in young mice [97].
T456 1972-2135 Sentence denotes Royal jelly also stimulated the differentiation of satellite stem cells both in vivo and in vitro and improved the regenerative capacity of injured muscle [96,97].
T457 2136-2235 Sentence denotes Therefore, royal jelly treatment might reduce the progression of age-related muscular atrophy [59].
T458 2236-2451 Sentence denotes Future RCTs that evaluate the effect of bee products on muscle qualities and motor performance in humans should be properly designed to include biological markers of motor functioning along with behavioral measures.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1706 1189-1196 Gene denotes insulin Gene:3630
1707 1294-1301 Gene denotes insulin Gene:3630
1708 1322-1345 Gene denotes tumor necrosis factor-α Gene:24835
1709 1347-1352 Gene denotes TNF-α Gene:24835
1710 1392-1397 Gene denotes IGF-1 Gene:24482
1711 1402-1407 Gene denotes IGF-1 Gene:24482
1712 1408-1413 Gene denotes TNF-α Gene:24835
1713 1554-1580 Gene denotes myogenic differentiation 1 Gene:17927
1714 1582-1586 Gene denotes MyoD Gene:17927
1715 1893-1898 Gene denotes MuRF1 Gene:433766
1716 1903-1912 Gene denotes atrogin-1 Gene:67731
1717 1600-1609 Gene denotes myostatin Gene:17700
1718 74-80 Species denotes people Tax:9606
1719 198-204 Species denotes people Tax:9606
1720 1625-1629 Species denotes mice Tax:10090
1721 1920-1924 Species denotes mice Tax:10090
1722 1961-1965 Species denotes mice Tax:10090
1723 2334-2340 Species denotes humans Tax:9606
1724 2201-2204 Gene denotes age Gene:81759
1725 1675-1678 Gene denotes age Gene:81759
1726 1279-1286 Chemical denotes glucose MESH:D005947
1727 1972-1983 Chemical denotes Royal jelly MESH:C058787
1728 2147-2158 Chemical denotes royal jelly MESH:C058787
1729 210-221 Disease denotes muscle loss MESH:D009135
1730 560-571 Disease denotes muscle loss MESH:D009135
1731 693-705 Disease denotes inflammation MESH:D007249
1732 1808-1822 Disease denotes muscle atrophy MESH:D009133
1733 2222-2229 Disease denotes atrophy MESH:D001284