PMC:7601109 / 41461-42315
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T270 | 146-153 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T271 | 158-163 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T272 | 415-422 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T273 | 427-437 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T274 | 538-548 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T93 | 751-763 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T557 | 6-7 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T558 | 48-49 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T559 | 184-193 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T560 | 363-372 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activates |
| T561 | 373-382 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T562 | 478-487 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T563 | 612-621 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T564 | 729-734 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T612 | 146-153 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T614 | 158-163 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T615 | 257-260 | Chemical | denotes | AMP | http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215 |
| T618 | 406-409 | Chemical | denotes | ATP | http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616 |
| T620 | 415-422 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T622 | 427-437 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T623 | 433-437 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T624 | 525-536 | Chemical | denotes | cholesterol | http://purl.obolibrary.org/obo/CHEBI_16113 |
| T625 | 538-548 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T626 | 544-548 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T104 | 0-4 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T105 | 0-4 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T106 | 0-4 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T107 | 158-174 | http://purl.obolibrary.org/obo/GO_0006629 | denotes | lipid metabolism |
| T108 | 164-174 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T109 | 257-279 | http://purl.obolibrary.org/obo/GO_0006756 | denotes | AMP or phosphorylation |
| T110 | 264-279 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T111 | 283-287 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T112 | 283-287 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T113 | 283-287 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T114 | 333-337 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T115 | 333-337 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T116 | 333-337 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T117 | 358-362 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T118 | 358-362 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T119 | 358-362 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T120 | 373-391 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T121 | 373-382 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T122 | 427-447 | http://purl.obolibrary.org/obo/GO_0019395 | denotes | fatty acid oxidation |
| T123 | 478-487 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T124 | 512-521 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T125 | 590-594 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T126 | 590-594 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T127 | 590-594 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T128 | 612-630 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling cascades |
| T129 | 612-621 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T130 | 654-674 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T131 | 654-667 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T132 | 751-763 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T133 | 807-816 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T134 | 807-816 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T135 | 818-828 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T136 | 834-843 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T137 | 834-843 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T45 | 765-781 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T257 | 0-175 | Sentence | denotes | AMPK, a heterotrimeric complex that consists of a catalytic subunit and two regulatory subunits, is an intracellular energy sensor that regulates glucose and lipid metabolism. |
| T258 | 176-345 | Sentence | denotes | It gets activated when cellular energy is depleted through allosteric binding of AMP or phosphorylation by AMPK kinase at Thr172 of the catalytic subunit by AMPK kinase. |
| T259 | 346-576 | Sentence | denotes | Upregulated AMPK activates signaling pathways that generate ATP from glucose and fatty acid oxidation, and it simultaneously blocks signaling that contributes to the synthesis of cholesterol, fatty acid, and triacylglycerol [111]. |
| T260 | 577-854 | Sentence | denotes | In addition, AMPK masters numerous signaling cascades such as Forkhead Box O transcription factor (FOXO) and AKT/mTOR, which regulate the expression of genes associated with inflammation, oxidative stress, mitochondrial function, autophagy, metabolism, and apoptosis [127,128]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 959 | 0-4 | Gene | denotes | AMPK | Gene:78975 |
| 960 | 283-287 | Gene | denotes | AMPK | Gene:78975 |
| 961 | 358-362 | Gene | denotes | AMPK | Gene:78975 |
| 962 | 590-594 | Gene | denotes | AMPK | Gene:78975 |
| 963 | 686-689 | Gene | denotes | AKT | Gene:24185 |
| 964 | 690-694 | Gene | denotes | mTOR | Gene:56718 |
| 965 | 146-153 | Chemical | denotes | glucose | MESH:D005947 |
| 966 | 158-163 | Chemical | denotes | lipid | MESH:D008055 |
| 967 | 257-260 | Chemical | denotes | AMP | MESH:D000249 |
| 968 | 298-304 | Chemical | denotes | Thr172 | |
| 969 | 406-409 | Chemical | denotes | ATP | MESH:D000255 |
| 970 | 415-422 | Chemical | denotes | glucose | MESH:D005947 |
| 971 | 427-437 | Chemical | denotes | fatty acid | MESH:D005227 |
| 972 | 525-536 | Chemical | denotes | cholesterol | MESH:D002784 |
| 973 | 538-548 | Chemical | denotes | fatty acid | MESH:D005227 |
| 974 | 554-569 | Chemical | denotes | triacylglycerol | MESH:D014280 |
| 975 | 751-763 | Disease | denotes | inflammation | MESH:D007249 |