> top > docs > PMC:7601109 > spans > 34910-40605 > annotations

PMC:7601109 / 34910-40605 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T41 107-130 Body_part denotes skeletal muscle tissues http://purl.obolibrary.org/obo/UBERON_0001134
T42 645-668 Body_part denotes skeletal muscle tissues http://purl.obolibrary.org/obo/UBERON_0001134
T43 1097-1111 Body_part denotes muscle tissues http://purl.obolibrary.org/obo/UBERON_0002385
T44 1311-1320 Body_part denotes hind limb http://purl.obolibrary.org/obo/UBERON_0002103
T45 1316-1320 Body_part denotes limb http://purl.obolibrary.org/obo/UBERON_0002101
T46 1422-1435 Body_part denotes soleus muscle http://purl.obolibrary.org/obo/UBERON_0001389
T47 1566-1571 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T48 1597-1610 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T49 2089-2102 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T50 2345-2358 Body_part denotes soleus muscle http://purl.obolibrary.org/obo/UBERON_0001389
T51 2572-2585 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T52 4759-4772 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T53 4916-4929 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T54 5074-5079 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T199 48-54 Body_part denotes Muscle http://purl.org/sig/ont/fma/fma32558
T200 107-130 Body_part denotes skeletal muscle tissues http://purl.org/sig/ont/fma/fma14069
T201 202-208 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T202 233-239 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T203 253-259 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T204 474-484 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T205 519-528 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T206 539-545 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T207 645-668 Body_part denotes skeletal muscle tissues http://purl.org/sig/ont/fma/fma14069
T208 984-987 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T209 996-1001 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T210 1042-1049 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 1097-1111 Body_part denotes muscle tissues http://purl.org/sig/ont/fma/fma9641
T212 1195-1200 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T213 1221-1230 Body_part denotes galactose http://purl.org/sig/ont/fma/fma82794
T214 1311-1320 Body_part denotes hind limb http://purl.org/sig/ont/fma/fma7184
T215 1397-1414 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T216 1409-1414 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 1422-1435 Body_part denotes soleus muscle http://purl.org/sig/ont/fma/fma22542
T218 1545-1551 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T219 1566-1571 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T220 1597-1617 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T221 2042-2049 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T222 2089-2109 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T223 2283-2285 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T224 2345-2358 Body_part denotes soleus muscle http://purl.org/sig/ont/fma/fma22542
T225 2549-2556 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T226 2572-2592 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T227 2664-2666 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T228 3165-3175 Body_part denotes peroxisome http://purl.org/sig/ont/fma/fma63845
T229 3246-3252 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T230 3315-3326 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T231 3395-3407 Body_part denotes muscle fiber http://purl.org/sig/ont/fma/fma67328
T232 3429-3433 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T233 3629-3636 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T234 3766-3772 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T235 3891-3900 Body_part denotes brown fat http://purl.org/sig/ont/fma/fma20118
T236 3938-3944 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T237 4608-4615 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T238 4626-4633 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T239 4759-4779 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T240 4869-4879 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T241 4884-4893 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T242 4916-4936 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T243 5074-5079 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T244 5203-5209 Body_part denotes purine http://purl.org/sig/ont/fma/fma82772
T245 5262-5267 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T246 5583-5587 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T247 5615-5621 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T80 233-247 Disease denotes muscle wasting http://purl.obolibrary.org/obo/MONDO_0004323
T81 1582-1585 Disease denotes SOD http://purl.obolibrary.org/obo/MONDO_0008428|http://purl.obolibrary.org/obo/MONDO_0019029
T83 1628-1631 Disease denotes SOD http://purl.obolibrary.org/obo/MONDO_0008428|http://purl.obolibrary.org/obo/MONDO_0019029
T85 1910-1918 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T86 2025-2033 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T87 2497-2500 Disease denotes SOD http://purl.obolibrary.org/obo/MONDO_0008428|http://purl.obolibrary.org/obo/MONDO_0019029
T89 2685-2697 Disease denotes malnourished http://purl.obolibrary.org/obo/MONDO_0006873
T90 4387-4395 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T91 4708-4716 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T412 39-54 http://purl.obolibrary.org/obo/UBERON_0001134 denotes Skeletal Muscle
T413 39-54 http://purl.obolibrary.org/obo/UBERON_0014892 denotes Skeletal Muscle
T414 39-54 http://www.ebi.ac.uk/efo/EFO_0000888 denotes Skeletal Muscle
T415 107-122 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T416 107-122 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T417 107-122 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T418 131-134 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T419 193-208 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T420 193-208 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T421 193-208 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T422 233-239 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T423 233-239 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T424 233-239 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T425 233-239 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T426 253-259 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T427 253-259 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T428 253-259 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T429 253-259 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T430 507-515 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T431 539-545 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T432 539-545 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T433 539-545 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T434 539-545 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T435 645-660 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T436 645-660 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T437 645-660 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T438 689-697 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T439 844-852 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T440 1097-1111 http://purl.obolibrary.org/obo/UBERON_0002385 denotes muscle tissues
T441 1148-1156 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T442 1217-1218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T443 1316-1320 http://www.ebi.ac.uk/efo/EFO_0000876 denotes limb
T444 1397-1414 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T445 1429-1435 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T446 1429-1435 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T447 1429-1435 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T448 1429-1435 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T449 1524-1532 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T450 1536-1551 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T451 1536-1551 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T452 1536-1551 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T453 1566-1571 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T454 1566-1571 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T455 1611-1617 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T456 1611-1617 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T457 1611-1617 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T458 1611-1617 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T459 2103-2109 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T460 2103-2109 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T461 2103-2109 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T462 2103-2109 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T463 2111-2114 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T464 2184-2192 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T465 2253-2261 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T466 2314-2315 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T467 2352-2358 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T468 2352-2358 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T469 2352-2358 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T470 2352-2358 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T471 2467-2475 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T472 2586-2592 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T473 2586-2592 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T474 2586-2592 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T475 2586-2592 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T476 2652-2660 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T477 2711-2712 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T478 2737-2747 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T479 2757-2759 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T480 2770-2771 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T481 2778-2787 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T482 2819-2828 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T483 2968-2976 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T484 3108-3118 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T485 3189-3198 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T486 3237-3252 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T487 3237-3252 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T488 3237-3252 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T489 3395-3401 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T490 3395-3401 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T491 3395-3401 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T492 3395-3401 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T493 3462-3463 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T494 3622-3628 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T495 3703-3712 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T496 3766-3772 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T497 3766-3772 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T498 3835-3840 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T499 3897-3900 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T500 3929-3944 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T501 3929-3944 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T502 3929-3944 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T503 3946-3949 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T504 3968-3976 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T505 4046-4054 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T506 4072-4078 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T507 4084-4093 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T508 4430-4431 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T509 4482-4483 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T510 4773-4779 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T511 4773-4779 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T512 4773-4779 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T513 4773-4779 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T514 4829-4830 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T515 4930-4936 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T516 4930-4936 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T517 4930-4936 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T518 4930-4936 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T519 4984-4999 http://purl.obolibrary.org/obo/PR_000010543 denotes myeloperoxidase
T520 5001-5016 http://purl.obolibrary.org/obo/PR_000010543 denotes Myeloperoxidase
T521 5074-5079 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T522 5095-5096 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T523 5304-5312 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T524 5337-5340 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T525 5583-5587 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T526 5606-5621 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T527 5606-5621 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T528 5606-5621 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T529 5674-5682 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T492 74-97 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T493 83-89 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T494 99-102 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T495 304-307 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T496 556-565 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T497 714-721 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T498 827-830 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T499 866-875 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T500 890-893 Chemical denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T503 894-900 Chemical denotes ribose http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013
T505 914-918 Chemical denotes PARP http://purl.obolibrary.org/obo/CHEBI_62913
T506 921-929 Chemical denotes xanthine http://purl.obolibrary.org/obo/CHEBI_15318|http://purl.obolibrary.org/obo/CHEBI_17712
T508 943-952 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T509 984-987 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T510 996-1001 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T511 1032-1035 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T512 1042-1049 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T513 1079-1082 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T515 1160-1171 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T516 1195-1200 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T517 1221-1230 Chemical denotes galactose http://purl.obolibrary.org/obo/CHEBI_28260
T518 1361-1364 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T519 1520-1523 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T520 1633-1644 Chemical denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925
T522 1877-1881 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T523 1991-1994 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T524 2042-2049 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T525 2067-2070 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T527 2147-2150 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T528 2265-2272 Chemical denotes citrate http://purl.obolibrary.org/obo/CHEBI_133748|http://purl.obolibrary.org/obo/CHEBI_16947|http://purl.obolibrary.org/obo/CHEBI_50744
T531 2283-2285 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T532 2293-2315 Chemical denotes hydroxyacyl coenzyme A http://purl.obolibrary.org/obo/CHEBI_62618
T533 2305-2315 Chemical denotes coenzyme A http://purl.obolibrary.org/obo/CHEBI_15346
T534 2305-2313 Chemical denotes coenzyme http://purl.obolibrary.org/obo/CHEBI_23354
T535 2442-2444 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T536 2457-2459 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T537 2505-2516 Chemical denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925
T539 2530-2533 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T540 2549-2556 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T541 2664-2666 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T542 2679-2681 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T543 2956-2967 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T544 3137-3140 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T545 3226-3229 Chemical denotes PGC http://purl.obolibrary.org/obo/CHEBI_26336
T546 3315-3326 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T547 3315-3320 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T548 3321-3326 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T549 3353-3364 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T550 3422-3425 Chemical denotes PGC http://purl.obolibrary.org/obo/CHEBI_26336
T551 3442-3445 Chemical denotes PGC http://purl.obolibrary.org/obo/CHEBI_26336
T552 3505-3508 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T553 3572-3575 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T554 3691-3694 Chemical denotes PGC http://purl.obolibrary.org/obo/CHEBI_26336
T555 3748-3757 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T556 3956-3967 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T557 3980-3991 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T558 3996-4000 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T559 4156-4168 Chemical denotes antioxidants http://purl.obolibrary.org/obo/CHEBI_22586
T560 4177-4181 Chemical denotes heme http://purl.obolibrary.org/obo/CHEBI_26355|http://purl.obolibrary.org/obo/CHEBI_30413
T562 4222-4230 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T563 4269-4272 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T564 4361-4365 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T565 4478-4480 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T568 4507-4514 Chemical denotes oxidant http://purl.obolibrary.org/obo/CHEBI_63248
T569 4554-4558 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T570 4608-4615 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T571 4616-4624 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T572 4626-4633 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T573 4649-4657 Chemical denotes xanthine http://purl.obolibrary.org/obo/CHEBI_15318|http://purl.obolibrary.org/obo/CHEBI_17712
T575 4671-4680 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T576 4811-4815 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T577 5056-5059 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T578 5144-5161 Chemical denotes hypochlorous acid http://purl.obolibrary.org/obo/CHEBI_24757
T579 5157-5161 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T580 5186-5190 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T581 5203-5209 Chemical denotes purine http://purl.obolibrary.org/obo/CHEBI_35584
T582 5222-5225 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T584 5250-5253 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T585 5262-5267 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T586 5316-5325 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T587 5368-5379 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T588 5456-5467 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T589 5507-5510 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T62 1083-1093 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism
T63 1248-1253 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T64 2071-2081 http://purl.obolibrary.org/obo/GO_0009056 denotes catabolism
T65 2166-2176 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T66 2778-2795 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T67 2778-2787 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T68 2819-2837 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T69 2819-2828 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T70 2850-2860 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T71 2865-2874 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T72 2865-2874 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T73 2956-2976 http://purl.obolibrary.org/obo/GO_0016209 denotes antioxidant activity
T74 3165-3188 http://purl.obolibrary.org/obo/GO_0016559 denotes peroxisome proliferator
T75 3782-3803 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T76 3782-3795 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T77 3867-3887 http://purl.obolibrary.org/obo/GO_0045333 denotes oxidative metabolism
T78 3877-3887 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T79 3956-3976 http://purl.obolibrary.org/obo/GO_0016209 denotes antioxidant activity
T80 4084-4101 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T81 4084-4093 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T82 4626-4647 http://purl.obolibrary.org/obo/GO_0017014 denotes protein nitrosylation
T83 5131-5140 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T84 5203-5217 http://purl.obolibrary.org/obo/GO_0043101 denotes purine salvage
T85 5222-5235 http://purl.obolibrary.org/obo/GO_0006754 denotes ATP synthesis
T86 5226-5235 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T37 19-35 Phenotype denotes Oxidative Stress http://purl.obolibrary.org/obo/HP_0025464
T38 224-231 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T39 233-247 Phenotype denotes muscle wasting http://purl.obolibrary.org/obo/HP_0003202
T40 253-268 Phenotype denotes muscle weakness http://purl.obolibrary.org/obo/HP_0001324
T41 331-356 Phenotype denotes mitochondrial dysfunction http://purl.obolibrary.org/obo/HP_0003287
T42 4387-4395 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T223 0-4 Sentence denotes 4.2.
T224 5-54 Sentence denotes Counteracting Oxidative Stress in Skeletal Muscle
T225 55-278 Sentence denotes High production of reactive oxygen species (ROS) in skeletal muscle tissues has serious destructive effects, which alter the integrity of skeletal muscle resulting into fatigue, muscle wasting, and muscle weakness [90,101].
T226 279-607 Sentence denotes Sources of intramuscular ROS are numerous including mitochondrial dysfunction (e.g., alteration of mitochondrial enzymes in the respiratory chain as well as enzymes responsible for β-oxidation), neutrophil infiltration, and the activity of cytokines and major muscle degrading molecules such as myostatin [21,36,38,101,102,118].
T227 608-826 Sentence denotes Oxidative and nitrosative damages in skeletal muscle tissues are mediated by the activity of numerous pro-oxidant enzymes that are associated with inflammatory processes such as cyclooxygenase-2 (COX-2) and iNOS [101].
T228 827-1122 Sentence denotes ROS triggers the activity of corrosive molecules such as poly (ADP-ribose) polymerase (PARP), xanthine oxidase, and adenosine deaminase, which contribute to DNA damage, lipid peroxidation (e.g., increased MDA), and protein nitrotyrosylation as well as ATP catabolism in muscle tissues [101,102].
T229 1123-1259 Sentence denotes Royal jelly enhanced the activity of antioxidant enzymes and suppressed lipid peroxidation in a d-galactose induced model of aging [95].
T230 1260-1475 Sentence denotes Two weeks of propolis treatment in rats undergoing hind limb unloading significantly reduced nuclear ROS levels and numbers of apoptotic endothelial cells in the soleus muscle to levels similar to normal rats [110].
T231 1476-1825 Sentence denotes Moreover, propolis significantly suppressed MDA activity in skeletal muscle and increased liver levels of SOD as well as gastrocnemius muscle levels of SOD, glutathione peroxidase and catalase in rats on eccentric exercise training (70% VO2max treadmill running exercise for 60 min) compared with rats receiving exercise alone or no treatment [109].
T232 1826-2116 Sentence denotes In addition, intraperitoneal pre-administration of CAPE (60 min before induction of ischemia reperfusion) significantly ameliorated the effects associated with high ROS levels, which accompany acute ischemia such as protein peroxidation and ATP catabolism in the gastrocnemius muscle [102].
T233 2117-2218 Sentence denotes Bee products probably reduced ROS production via regulation of the activity of mitochondrial enzymes.
T234 2219-2395 Sentence denotes Royal jelly increased the maximal activity of citrate synthase (CS) and β-hydroxyacyl coenzyme A dehydrogenase (β-HAD) in the soleus muscle of rats on endurance training [106].
T235 2396-2629 Sentence denotes Bee pollen restored mitochondrial complex-I, -II, -III, and -IV enzyme activity to normal, increased SOD and glutathione, and reduced MDA, NO, and total protein content in the gastrocnemius muscle of rats on exhaustive exercise [90].
T236 2630-2920 Sentence denotes It also increased the activity of CS and complex IV in malnourished old rats via a mechanism that involved activation of mTOR [36]. mTOR is a major signaling pathway that regulates various signaling cascades involved in metabolism and autophagy such nuclear respiratory factor 2 (NRF2) [2].
T237 2921-3119 Sentence denotes Therefore, it is possible that the antioxidant activity demonstrated by bee products, particularly that expressed in the mitochondria, is associated with their metabolic and hypoglycemic activities.
T238 3120-3280 Sentence denotes For instance, 10-HDA increased expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in skeletal muscle of diabetic mice [112,119].
T239 3281-3441 Sentence denotes Similarly, aged mice treated with amino acids similar to those found in royal jelly demonstrated improved size of muscle fiber by increasing PGC-1α mRNA levels.
T240 3442-3668 Sentence denotes PGC-1α functions as a key regulator of sirtuin 1, which limits ROS production through stimulation of mitochondrial biogenesis and ROS defense system, thus protecting metabolically active tissues against oxidative damage [120].
T241 3669-3951 Sentence denotes Mechanistically, when PGC-1α gets activated, it interacts with other bioactive molecules such as muscle-specific transcription factors to stimulate the expression of genes that induce mitochondrial oxidative metabolism in brown fat and fiber-type switching in skeletal muscle [121].
T242 3952-4237 Sentence denotes The antioxidant activity of royal jelly and CAPE might be related to their strong capacity to activate the master redox-active NRF2 signaling pathway [73,122], which stimulates the production of internal antioxidants such as heme oxygenase-1 (HO-1), which scavenge free radicals [123].
T243 4238-4343 Sentence denotes Meanwhile, NRF2 and HO-1 block ROS production indirectly via suppression of inflammatory reactions [122].
T244 4344-4536 Sentence denotes In this context, CAPE reduced degenerative myopathy in rats on eccentric exercise via a complex mechanism that involved inhibition of NF-κB and its downstream pro-oxidant COX-2 and iNOS [101].
T245 4537-4794 Sentence denotes Correspondingly, CAPE decreased markers of oxidative cellular damages (protein carbonyl, protein nitrosylation, xanthine oxidase, and adenosine deaminase) associated with ischemia reperfusion and eccentric exercise in the gastrocnemius muscle [101,102,103].
T246 4795-5000 Sentence denotes In this regard, CAPE operated via a mechanism that involved inhibition of neutrophil and leukocyte infiltration into the gastrocnemius muscle, which was associated with decreased levels of myeloperoxidase.
T247 5001-5172 Sentence denotes Myeloperoxidase contributes to excessive production of ROS and oxidative organ damage through a mechanism that embroils increased synthesis of hypochlorous acid [101,102].
T248 5173-5342 Sentence denotes Furthermore, CAPE accelerated purine salvage for ATP synthesis and inhibited ROS-induced lipid peroxidation via attenuation of the activity of adenosine deaminase [102].
T249 5343-5695 Sentence denotes In summary, the reported antioxidant effects of bee products were multifaceted involving increased production of antioxidant enzymes [90,95,109,110], and decreased ROS production [90,101,102,103,110] (secondary to reduction of inflammatory cell infiltration into skeletal muscle) [90,101,102,103], and restoration of mitochondrial activity [36,90,106].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
737 29-35 Disease denotes Stress MESH:D000079225
754 786-802 Gene denotes cyclooxygenase-2 Gene:29527
755 804-809 Gene denotes COX-2 Gene:29527
756 884-912 Gene denotes poly (ADP-ribose) polymerase Gene:25591
757 914-918 Gene denotes PARP Gene:11545
758 943-962 Gene denotes adenosine deaminase Gene:24165
759 574-583 Gene denotes myostatin Gene:29152
760 815-819 Gene denotes iNOS Gene:24599
761 74-97 Chemical denotes reactive oxygen species MESH:D017382
762 99-102 Chemical denotes ROS MESH:D017382
763 304-307 Chemical denotes ROS MESH:D017382
764 827-830 Chemical denotes ROS MESH:D017382
765 1079-1082 Chemical denotes ATP MESH:D000255
766 224-231 Disease denotes fatigue MESH:D005221
767 233-247 Disease denotes muscle wasting MESH:D009133
768 253-268 Disease denotes muscle weakness MESH:D018908
769 331-356 Disease denotes mitochondrial dysfunction MESH:D028361
785 1660-1668 Gene denotes catalase Gene:24248
786 1295-1299 Species denotes rats Tax:10116
787 1464-1468 Species denotes rats Tax:10116
788 1672-1676 Species denotes rats Tax:10116
789 1773-1777 Species denotes rats Tax:10116
790 1877-1882 Gene denotes CAPE Gene:362519
791 1123-1134 Chemical denotes Royal jelly MESH:C058787
792 1195-1200 Chemical denotes lipid MESH:D008055
793 1219-1230 Chemical denotes d-galactose MESH:D005690
794 1361-1364 Chemical denotes ROS MESH:D017382
795 1633-1644 Chemical denotes glutathione MESH:D005978
796 1991-1994 Chemical denotes ROS MESH:D017382
797 2067-2070 Chemical denotes ATP MESH:D000255
798 1910-1918 Disease denotes ischemia MESH:D007511
799 2019-2033 Disease denotes acute ischemia MESH:D007511
825 2265-2281 Gene denotes citrate synthase Gene:170587
826 2283-2285 Gene denotes CS Gene:170587
827 2751-2755 Gene denotes mTOR Gene:56718
828 2762-2766 Gene denotes mTOR Gene:56718
829 2880-2908 Gene denotes nuclear respiratory factor 2 Gene:83619
830 2910-2914 Gene denotes NRF2 Gene:83619
831 3165-3224 Gene denotes peroxisome proliferator-activated receptor-γ coactivator-1α Gene:19017
832 3226-3232 Gene denotes PGC-1α Gene:19017
833 3422-3428 Gene denotes PGC-1α Gene:19017
834 3442-3448 Gene denotes PGC-1α Gene:19017
835 3481-3490 Gene denotes sirtuin 1 Gene:309757
836 3691-3697 Gene denotes PGC-1α Gene:19017
837 2664-2666 Gene denotes CS Gene:170587
838 2362-2366 Species denotes rats Tax:10116
839 2596-2600 Species denotes rats Tax:10116
840 2702-2706 Species denotes rats Tax:10116
841 3265-3269 Species denotes mice Tax:10090
842 3297-3301 Species denotes mice Tax:10090
843 3897-3900 Gene denotes fat Gene:12491
844 2147-2150 Chemical denotes ROS MESH:D017382
845 2219-2230 Chemical denotes Royal jelly MESH:C058787
846 2505-2516 Chemical denotes glutathione MESH:D005978
847 3505-3508 Chemical denotes ROS MESH:D017382
848 3572-3575 Chemical denotes ROS MESH:D017382
849 3256-3264 Disease denotes diabetic MESH:D003920
879 4079-4083 Gene denotes NRF2 Gene:83619
880 4177-4193 Gene denotes heme oxygenase-1 Gene:24451
881 4195-4199 Gene denotes HO-1 Gene:24451
882 4249-4253 Gene denotes NRF2 Gene:83619
883 4258-4262 Gene denotes HO-1 Gene:24451
884 4478-4483 Gene denotes NF-κB Gene:18033
885 4515-4520 Gene denotes COX-2 Gene:29527
886 4525-4529 Gene denotes iNOS Gene:24599
887 4671-4690 Gene denotes adenosine deaminase Gene:24165
888 4984-4999 Gene denotes myeloperoxidase Gene:303413
889 5001-5016 Gene denotes Myeloperoxidase Gene:303413
890 5316-5335 Gene denotes adenosine deaminase Gene:24165
891 4399-4403 Species denotes rats Tax:10116
892 3980-3991 Chemical denotes royal jelly MESH:C058787
893 3996-4000 Chemical denotes CAPE MESH:C055494
894 4217-4230 Chemical denotes free radicals MESH:D005609
895 4269-4272 Chemical denotes ROS MESH:D017382
896 4361-4365 Chemical denotes CAPE MESH:C055494
897 4554-4558 Chemical denotes CAPE MESH:C055494
898 4811-4815 Chemical denotes CAPE MESH:C055494
899 5056-5059 Chemical denotes ROS MESH:D017382
900 5144-5161 Chemical denotes hypochlorous acid MESH:D006997
901 5186-5190 Chemical denotes CAPE MESH:C055494
902 5203-5209 Chemical denotes purine MESH:C030985
903 5222-5225 Chemical denotes ATP MESH:D000255
904 5250-5253 Chemical denotes ROS MESH:D017382
905 5262-5267 Chemical denotes lipid MESH:D008055
906 4374-4395 Disease denotes degenerative myopathy MESH:D009135
907 4708-4716 Disease denotes ischemia MESH:D007511
909 5507-5510 Chemical denotes ROS MESH:D017382