PMC:7601109 / 24504-25599 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Propolis exists in a plethora of commercial products that are directly consumed or used by humans e.g., lozenges, soap, toothpastes and mouth wash, creams, gels, cough syrups, wines, cakes, chewing gums, candies, shampoo, chocolate, skin lotions, processed meat, etc. [67]. In addition, royal jelly, bee pollen, and propolis are widely used as dietary supplements in many parts of the world [36,37,38,39]. Existing knowledge denotes no adverse effects from their consumption either in rodents or in humans [39,66]. The safety of pinocembrin, a flavonoid available in propolis and an approved drug in China, is documented since its elimination from the body is rapid [91]. The safety profile of bee pollen (both crude and processed) has been empirically tested. Oral consumption of bee pollen (up to 2 g/kg body weight) expressed no allergic reactions in mice including behavioral changes, salivation, diarrhea, respiratory or autonomic responses, restlessness, convulsions, tremors, or death [90]. In fact, the German Federal Board of Health acknowledges bee pollen as an official medicine [36].","tracks":[{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":136,"end":141},"obj":"Body_part"},{"id":"T15","span":{"begin":233,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0000165"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T83667","span":{"begin":136,"end":141},"obj":"Body_part"},{"id":"T98336","span":{"begin":233,"end":237},"obj":"Body_part"},{"id":"T30999","span":{"begin":652,"end":656},"obj":"Body_part"},{"id":"T53830","span":{"begin":806,"end":810},"obj":"Body_part"}],"attributes":[{"id":"A87299","pred":"fma_id","subj":"T83667","obj":"http://purl.org/sig/ont/fma/fma49184"},{"id":"A61821","pred":"fma_id","subj":"T98336","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A93909","pred":"fma_id","subj":"T30999","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A47935","pred":"fma_id","subj":"T53830","obj":"http://purl.org/sig/ont/fma/fma256135"},{"subj":"T83667","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T98336","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30999","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T53830","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T46","span":{"begin":832,"end":850},"obj":"Disease"},{"id":"T48","span":{"begin":832,"end":840},"obj":"Disease"},{"id":"T49","span":{"begin":901,"end":909},"obj":"Disease"}],"attributes":[{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0000605"},{"id":"A47","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0004980"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T210","span":{"begin":19,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T211","span":{"begin":91,"end":97},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T212","span":{"begin":136,"end":141},"obj":"http://www.ebi.ac.uk/efo/EFO_0000825"},{"id":"T213","span":{"begin":198,"end":202},"obj":"http://www.ebi.ac.uk/efo/EFO_0001925"},{"id":"T214","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T215","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T216","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T217","span":{"begin":233,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T218","span":{"begin":233,"end":237},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T219","span":{"begin":499,"end":505},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T220","span":{"begin":542,"end":543},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T221","span":{"begin":732,"end":735},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T222","span":{"begin":753,"end":759},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T223","span":{"begin":1091,"end":1093},"obj":"http://purl.obolibrary.org/obo/CLO_0001313"}],"attributes":[{"subj":"T210","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T397","span":{"begin":287,"end":298},"obj":"Chemical"},{"id":"T398","span":{"begin":529,"end":540},"obj":"Chemical"},{"id":"T399","span":{"begin":544,"end":553},"obj":"Chemical"},{"id":"T401","span":{"begin":592,"end":596},"obj":"Chemical"},{"id":"T402","span":{"begin":1081,"end":1089},"obj":"Chemical"}],"attributes":[{"id":"A397","pred":"chebi_id","subj":"T397","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A398","pred":"chebi_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/CHEBI_28157"},{"id":"A399","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_47916"},{"id":"A400","pred":"chebi_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/CHEBI_72544"},{"id":"A401","pred":"chebi_id","subj":"T401","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A402","pred":"chebi_id","subj":"T402","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T397","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T398","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T399","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T401","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T402","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T70492","span":{"begin":190,"end":197},"obj":"http://purl.obolibrary.org/obo/GO_0071626"},{"id":"T63608","span":{"begin":889,"end":899},"obj":"http://purl.obolibrary.org/obo/GO_0046541"}],"attributes":[{"subj":"T70492","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T63608","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T22","span":{"begin":21,"end":29},"obj":"Phenotype"},{"id":"T23","span":{"begin":162,"end":167},"obj":"Phenotype"},{"id":"T24","span":{"begin":869,"end":887},"obj":"Phenotype"},{"id":"T25","span":{"begin":901,"end":909},"obj":"Phenotype"},{"id":"T26","span":{"begin":947,"end":959},"obj":"Phenotype"},{"id":"T27","span":{"begin":974,"end":981},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0001050"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0000708"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0000711"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0001337"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T159","span":{"begin":0,"end":273},"obj":"Sentence"},{"id":"T160","span":{"begin":274,"end":405},"obj":"Sentence"},{"id":"T161","span":{"begin":406,"end":514},"obj":"Sentence"},{"id":"T162","span":{"begin":515,"end":671},"obj":"Sentence"},{"id":"T163","span":{"begin":672,"end":760},"obj":"Sentence"},{"id":"T164","span":{"begin":761,"end":997},"obj":"Sentence"},{"id":"T165","span":{"begin":998,"end":1095},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T159","pred":"source","obj":"LitCovid-sentences"},{"subj":"T160","pred":"source","obj":"LitCovid-sentences"},{"subj":"T161","pred":"source","obj":"LitCovid-sentences"},{"subj":"T162","pred":"source","obj":"LitCovid-sentences"},{"subj":"T163","pred":"source","obj":"LitCovid-sentences"},{"subj":"T164","pred":"source","obj":"LitCovid-sentences"},{"subj":"T165","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"472","span":{"begin":91,"end":97},"obj":"Species"},{"id":"473","span":{"begin":222,"end":231},"obj":"Species"},{"id":"474","span":{"begin":499,"end":505},"obj":"Species"},{"id":"475","span":{"begin":854,"end":858},"obj":"Species"},{"id":"476","span":{"begin":529,"end":540},"obj":"Chemical"},{"id":"477","span":{"begin":544,"end":553},"obj":"Chemical"},{"id":"478","span":{"begin":162,"end":174},"obj":"Disease"},{"id":"479","span":{"begin":832,"end":850},"obj":"Disease"},{"id":"480","span":{"begin":901,"end":909},"obj":"Disease"},{"id":"481","span":{"begin":961,"end":972},"obj":"Disease"},{"id":"482","span":{"begin":974,"end":981},"obj":"Disease"},{"id":"483","span":{"begin":986,"end":991},"obj":"Disease"}],"attributes":[{"id":"A472","pred":"tao:has_database_id","subj":"472","obj":"Tax:9606"},{"id":"A473","pred":"tao:has_database_id","subj":"473","obj":"Tax:3641"},{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"Tax:9606"},{"id":"A475","pred":"tao:has_database_id","subj":"475","obj":"Tax:10090"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"MESH:C016063"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"MESH:D005419"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"MESH:D003371"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"MESH:D004342"},{"id":"A480","pred":"tao:has_database_id","subj":"480","obj":"MESH:D003967"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D012640"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"MESH:D014202"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"MESH:D003643"},{"subj":"472","pred":"source","obj":"LitCovid-PubTator"},{"subj":"473","pred":"source","obj":"LitCovid-PubTator"},{"subj":"474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"479","pred":"source","obj":"LitCovid-PubTator"},{"subj":"480","pred":"source","obj":"LitCovid-PubTator"},{"subj":"481","pred":"source","obj":"LitCovid-PubTator"},{"subj":"482","pred":"source","obj":"LitCovid-PubTator"},{"subj":"483","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-UBERON","color":"#93ecaf","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec9593"},{"id":"LitCovid-PD-MONDO","color":"#93aaec"},{"id":"LitCovid-PD-CLO","color":"#c4ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93de"},{"id":"LitCovid-PD-GO-BP","color":"#93ecdf"},{"id":"LitCovid-PD-HP","color":"#ecc593"},{"id":"LitCovid-sentences","color":"#ab93ec"},{"id":"LitCovid-PubTator","color":"#94ec93"}]}]}}