PMC:7601109 / 24504-25599 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Propolis exists in a plethora of commercial products that are directly consumed or used by humans e.g., lozenges, soap, toothpastes and mouth wash, creams, gels, cough syrups, wines, cakes, chewing gums, candies, shampoo, chocolate, skin lotions, processed meat, etc. [67]. In addition, royal jelly, bee pollen, and propolis are widely used as dietary supplements in many parts of the world [36,37,38,39]. Existing knowledge denotes no adverse effects from their consumption either in rodents or in humans [39,66]. The safety of pinocembrin, a flavonoid available in propolis and an approved drug in China, is documented since its elimination from the body is rapid [91]. The safety profile of bee pollen (both crude and processed) has been empirically tested. Oral consumption of bee pollen (up to 2 g/kg body weight) expressed no allergic reactions in mice including behavioral changes, salivation, diarrhea, respiratory or autonomic responses, restlessness, convulsions, tremors, or death [90]. In fact, the German Federal Board of Health acknowledges bee pollen as an official medicine 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