PMC:7600245 / 95332-96916
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T431 | 220-228 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T432 | 398-409 | Body_part | denotes | microtubule | http://purl.org/sig/ont/fma/fma63849 |
| T433 | 497-501 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T434 | 608-612 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T435 | 654-682 | Body_part | denotes | polymorphonuclear leukocytes | http://purl.org/sig/ont/fma/fma62860 |
| T436 | 805-813 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T437 | 959-969 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T438 | 1057-1066 | Body_part | denotes | capillary | http://purl.org/sig/ont/fma/fma63194 |
| T439 | 1180-1188 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T440 | 1193-1196 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T441 | 1259-1267 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T442 | 1321-1329 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T443 | 1336-1340 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T444 | 1422-1433 | Body_part | denotes | Interleukin | http://purl.org/sig/ont/fma/fma86578 |
| T445 | 1479-1486 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T446 | 1530-1533 | Body_part | denotes | CSF | http://purl.org/sig/ont/fma/fma20935 |
| T447 | 1535-1546 | Body_part | denotes | granulocyte | http://purl.org/sig/ont/fma/fma62854 |
| T448 | 1547-1557 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T48 | 1057-1066 | Body_part | denotes | capillary | http://purl.obolibrary.org/obo/UBERON_0001982 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T434 | 99-107 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T435 | 959-979 | Disease | denotes | neutrophil migration | http://purl.obolibrary.org/obo/MONDO_0008091 |
| T436 | 1461-1464 | Disease | denotes | NOD | http://purl.obolibrary.org/obo/MONDO_0007435 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T952 | 108-109 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T953 | 175-176 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T954 | 199-208 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Humanized |
| T955 | 254-256 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T956 | 478-483 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T957 | 608-612 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T958 | 788-793 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T959 | 866-872 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Active |
| T960 | 1163-1168 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T961 | 1304-1309 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
| T962 | 1346-1347 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T963 | 1373-1374 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T21219 | 70-75 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T699 | 230-232 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T32906 | 269-275 | Chemical | denotes | Jakafi | http://purl.obolibrary.org/obo/CHEBI_66917 |
| T29671 | 284-292 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T11714 | 306-315 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T704 | 321-331 | Chemical | denotes | Colchicine | http://purl.obolibrary.org/obo/CHEBI_27882 |
| T65432 | 348-356 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T8416 | 484-495 | Chemical | denotes | polypeptide | http://purl.obolibrary.org/obo/CHEBI_15841 |
| T53143 | 497-499 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T51068 | 511-521 | Chemical | denotes | antagonist | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T84855 | 566-574 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T711 | 731-739 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T50772 | 753-762 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T713 | 815-817 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T24627 | 842-855 | Chemical | denotes | Dexamethasone | http://purl.obolibrary.org/obo/CHEBI_41879 |
| T716 | 856-864 | Chemical | denotes | Decadron | http://purl.obolibrary.org/obo/CHEBI_41879 |
| T717 | 893-901 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T718 | 918-932 | Chemical | denotes | glucocorticoid | http://purl.obolibrary.org/obo/CHEBI_24261 |
| T719 | 1085-1094 | Chemical | denotes | Sirolimus | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T720 | 1095-1103 | Chemical | denotes | Rapamune | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T721 | 1112-1120 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T722 | 1127-1144 | Chemical | denotes | pathway inhibitor | http://purl.obolibrary.org/obo/CHEBI_76932 |
| T723 | 1135-1144 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T724 | 1190-1192 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
| T725 | 1274-1276 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T727 | 1336-1338 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T729 | 1418-1420 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T731 | 1479-1486 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T732 | 1516-1525 | Chemical | denotes | rapamycin | http://purl.obolibrary.org/obo/CHEBI_9168 |
| T733 | 1527-1529 | Chemical | denotes | GM | http://purl.obolibrary.org/obo/CHEBI_74120 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T191 | 398-424 | http://purl.obolibrary.org/obo/GO_0046785 | denotes | microtubule polymerization |
| T192 | 608-623 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T193 | 959-979 | http://purl.obolibrary.org/obo/GO_1990266 | denotes | neutrophil migration |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T107 | 1047-1079 | Phenotype | denotes | increased capillary permeability | http://purl.obolibrary.org/obo/HP_0030005 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T786 | 0-110 | Sentence | denotes | Table 2 Most frequently evaluated anti-inflammatory/immunomodulatory drugs in clinical trials for COVID-19 a. |
| T787 | 111-176 | Sentence | denotes | Therapy Type Mechanism No. of Interventional Clinical Trials b |
| T788 | 177-256 | Sentence | denotes | Tocilizumab(Actemra) Humanized monoclonal antibody IL-6 receptor blocker ~41 |
| T789 | 257-320 | Sentence | denotes | Ruxolitinib(Jakafi) Small molecule JAK 1 and 2 inhibitor ~15 |
| T790 | 321-429 | Sentence | denotes | Colchicine(Colcrys) Small molecule Inhibition of NLRP3 inflammasome and of microtubule polymerization ~15 |
| T791 | 430-526 | Sentence | denotes | Anakinra(Kineret) Recombinant non-glycosylated human polypeptide IL-1 receptor antagonist ~13 |
| T792 | 527-701 | Sentence | denotes | Methylprednisolone (DEPOMedrol) Small molecule Intracellular receptor-mediated gene expression & suppression of migration of polymorphonuclear leukocytes, among others ~13 |
| T793 | 702-767 | Sentence | denotes | Baricitinib(Olumiant) Small molecule JAK 1 and 2 inhibitor ~12 |
| T794 | 768-841 | Sentence | denotes | Sarilumab(Kevzara) Human monoclonal antibody IL-6 receptor blocker ~10 |
| T795 | 842-1084 | Sentence | denotes | Dexamethasone(Decadron, Active Injection D) Small molecule Stimulation of glucocorticoid receptors, suppression of neutrophil migration, suppression of inflammatory mediators production, and reversal of increased capillary permeability ~10 |
| T796 | 1085-1148 | Sentence | denotes | Sirolimus(Rapamune) Small molecule mTOR pathway inhibitor ~4 |
| T797 | 1149-1217 | Sentence | denotes | Mavrilimumab Human monoclonal antibody GM-CSF receptor blocker ~4 |
| T798 | 1218-1282 | Sentence | denotes | Siltuximab(Sylvant) Chimeric monoclonal antibody Anti-IL-6 ~2 |
| T799 | 1283-1345 | Sentence | denotes | Canakinumab(Ilaris) Human monoclonal antibody Anti-IL-1β ~2 |
| T800 | 1346-1402 | Sentence | denotes | a From clinicaltrials.gov, b No. is as of July 25, 2020. |
| T801 | 1403-1421 | Sentence | denotes | Abbreviations: IL: |
| T802 | 1422-1439 | Sentence | denotes | Interleukin; JAK: |
| T803 | 1440-1584 | Sentence | denotes | Janus kinase; NLRP3: NOD-like receptor protein 3; mTOR: mammalian target of rapamycin; GM-CSF: granulocyte macrophage colony-stimulating factor. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 4070 | 294-305 | Gene | denotes | JAK 1 and 2 | Gene:3716 |
| 4071 | 372-377 | Gene | denotes | NLRP3 | Gene:114548 |
| 4072 | 741-752 | Gene | denotes | JAK 1 and 2 | Gene:3716 |
| 4073 | 1122-1126 | Gene | denotes | mTOR | Gene:2475 |
| 4074 | 1274-1278 | Gene | denotes | IL-6 | Gene:3569 |
| 4075 | 1336-1341 | Gene | denotes | IL-1β | Gene:3552 |
| 4076 | 478-483 | Species | denotes | human | Tax:9606 |
| 4077 | 788-793 | Species | denotes | Human | Tax:9606 |
| 4078 | 1163-1168 | Species | denotes | Human | Tax:9606 |
| 4079 | 1304-1309 | Species | denotes | Human | Tax:9606 |
| 4080 | 815-819 | Gene | denotes | IL-6 | Gene:3569 |
| 4081 | 230-234 | Gene | denotes | IL-6 | Gene:3569 |
| 4082 | 177-188 | Chemical | denotes | Tocilizumab | MESH:C502936 |
| 4083 | 189-196 | Chemical | denotes | Actemra | MESH:C502936 |
| 4084 | 257-268 | Chemical | denotes | Ruxolitinib | MESH:C540383 |
| 4085 | 321-331 | Chemical | denotes | Colchicine | MESH:D003078 |
| 4087 | 99-107 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 4092 | 1435-1438 | Gene | denotes | JAK | Gene:3716 |
| 4093 | 1454-1459 | Gene | denotes | NLRP3 | Gene:114548 |
| 4094 | 1490-1494 | Gene | denotes | mTOR | Gene:2475 |
| 4095 | 1496-1525 | Gene | denotes | mammalian target of rapamycin | Gene:2475 |