PMC:7600245 / 92398-92789 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T428","span":{"begin":144,"end":147},"obj":"Body_part"}],"attributes":[{"id":"A428","pred":"fma_id","subj":"T428","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Also depicted is its activation to the corresponding tri-phosphorylated form which exhibits a broad-spectrum antiviral activity against various RNA viruses, including coronaviruses with resistance mutations to remdesivir. (B) The active form exists in two forms: the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T928","span":{"begin":21,"end":31},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T929","span":{"begin":92,"end":93},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T930","span":{"begin":119,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T931","span":{"begin":148,"end":155},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T932","span":{"begin":223,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T933","span":{"begin":230,"end":236},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Also depicted is its activation to the corresponding tri-phosphorylated form which exhibits a broad-spectrum antiviral activity against various RNA viruses, including coronaviruses with resistance mutations to remdesivir. (B) The active form exists in two forms: the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T15387","span":{"begin":109,"end":118},"obj":"Chemical"},{"id":"T22024","span":{"begin":210,"end":220},"obj":"Chemical"},{"id":"T30933","span":{"begin":267,"end":272},"obj":"Chemical"},{"id":"T38286","span":{"begin":291,"end":298},"obj":"Chemical"},{"id":"T50020","span":{"begin":314,"end":323},"obj":"Chemical"},{"id":"T71234","span":{"begin":357,"end":365},"obj":"Chemical"},{"id":"T55928","span":{"begin":381,"end":390},"obj":"Chemical"}],"attributes":[{"id":"A22155","pred":"chebi_id","subj":"T15387","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A95979","pred":"chebi_id","subj":"T22024","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A30573","pred":"chebi_id","subj":"T30933","obj":"http://purl.obolibrary.org/obo/CHEBI_25750"},{"id":"A88669","pred":"chebi_id","subj":"T38286","obj":"http://purl.obolibrary.org/obo/CHEBI_16704"},{"id":"A47565","pred":"chebi_id","subj":"T50020","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A36323","pred":"chebi_id","subj":"T71234","obj":"http://purl.obolibrary.org/obo/CHEBI_17562"},{"id":"A12503","pred":"chebi_id","subj":"T55928","obj":"http://purl.obolibrary.org/obo/CHEBI_16750"}],"text":"Also depicted is its activation to the corresponding tri-phosphorylated form which exhibits a broad-spectrum antiviral activity against various RNA viruses, including coronaviruses with resistance mutations to remdesivir. (B) The active form exists in two forms: the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine."}

{"project":"LitCovid-sentences","denotations":[{"id":"T746","span":{"begin":0,"end":391},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Also depicted is its activation to the corresponding tri-phosphorylated form which exhibits a broad-spectrum antiviral activity against various RNA viruses, including coronaviruses with resistance mutations to remdesivir. (B) The active form exists in two forms: the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3984","span":{"begin":167,"end":180},"obj":"Species"},{"id":"3989","span":{"begin":210,"end":220},"obj":"Chemical"},{"id":"3990","span":{"begin":267,"end":272},"obj":"Chemical"},{"id":"3991","span":{"begin":291,"end":298},"obj":"Chemical"},{"id":"3992","span":{"begin":314,"end":323},"obj":"Chemical"},{"id":"3993","span":{"begin":357,"end":365},"obj":"Chemical"},{"id":"3994","span":{"begin":381,"end":390},"obj":"Chemical"}],"attributes":[{"id":"A3984","pred":"tao:has_database_id","subj":"3984","obj":"Tax:11118"},{"id":"A3989","pred":"tao:has_database_id","subj":"3989","obj":"MESH:C000606551"},{"id":"A3990","pred":"tao:has_database_id","subj":"3990","obj":"MESH:D010091"},{"id":"A3991","pred":"tao:has_database_id","subj":"3991","obj":"MESH:D014529"},{"id":"A3992","pred":"tao:has_database_id","subj":"3992","obj":"MESH:D000241"},{"id":"A3993","pred":"tao:has_database_id","subj":"3993","obj":"MESH:D003562"},{"id":"A3994","pred":"tao:has_database_id","subj":"3994","obj":"MESH:D006151"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Also depicted is its activation to the corresponding tri-phosphorylated form which exhibits a broad-spectrum antiviral activity against various RNA viruses, including coronaviruses with resistance mutations to remdesivir. (B) The active form exists in two forms: the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine."}