PMC:7600245 / 66790-68382
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T296 | 86-94 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
| T297 | 95-105 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T298 | 703-706 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T299 | 912-918 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T300 | 1413-1422 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T314 | 359-367 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T315 | 609-618 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T316 | 1079-1094 | Disease | denotes | cystic fibrosis | http://purl.obolibrary.org/obo/MONDO_0009061 |
| T317 | 1098-1135 | Disease | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T318 | 1118-1135 | Disease | denotes | pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T319 | 1576-1585 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T685 | 41-42 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T686 | 619-620 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T687 | 651-654 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T688 | 912-918 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T689 | 1305-1306 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T690 | 1449-1452 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T89040 | 8-22 | Chemical | denotes | Acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
| T2227 | 49-57 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T19167 | 71-76 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T75241 | 77-82 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T85167 | 86-94 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
| T44781 | 95-105 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T57293 | 95-100 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T82148 | 101-105 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T40906 | 133-149 | Chemical | denotes | N-acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
| T3142 | 135-149 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
| T43653 | 207-216 | Chemical | denotes | mucolytic | http://purl.obolibrary.org/obo/CHEBI_77034 |
| T99710 | 441-450 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T83493 | 452-463 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T212 | 546-560 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
| T213 | 636-650 | Chemical | denotes | Acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
| T3225 | 845-859 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
| T97343 | 971-987 | Chemical | denotes | sulfhydryl group | http://purl.obolibrary.org/obo/CHEBI_29917 |
| T30091 | 982-987 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T69479 | 1000-1009 | Chemical | denotes | disulfide | http://purl.obolibrary.org/obo/CHEBI_48343 |
| T218 | 1168-1182 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
| T219 | 1206-1217 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T1476 | 1341-1352 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T51876 | 1353-1364 | Chemical | denotes | glutathione | http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925 |
| T39047 | 1434-1448 | Chemical | denotes | Acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T135 | 576-605 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibit the viral replication |
| T136 | 588-605 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T137 | 588-605 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
| T138 | 1324-1333 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T139 | 1384-1393 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T140 | 1518-1539 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T82 | 1098-1135 | Phenotype | denotes | chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/HP_0006510 |
| T83 | 1275-1291 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T84 | 1485-1501 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T85 | 1576-1585 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T516 | 0-5 | Sentence | denotes | 4.15. |
| T517 | 6-34 | Sentence | denotes | N-Acetylcysteine (Acetadote) |
| T518 | 35-132 | Sentence | denotes | It is a small molecule in which the amino group of cysteine amino acid is acetylated (Figure S6). |
| T519 | 133-174 | Sentence | denotes | N-acetylcysteine was approved by the U.S. |
| T520 | 175-280 | Sentence | denotes | FDA in 1963 for the oral use as mucolytic agent and parenteral use to treat acetaminophen overdose [235]. |
| T521 | 281-377 | Sentence | denotes | Currently, there are about six ongoing clinical trials to evaluate its use in COVID-19 patients. |
| T522 | 378-494 | Sentence | denotes | The rationale for these studies is attributed to its potential antiviral, antioxidant, and immunomodulatory effects. |
| T523 | 495-635 | Sentence | denotes | In this arena, several experiments have shown that acetylcysteine may eventually inhibit the viral replication of influenza A [236,237,238]. |
| T524 | 636-739 | Sentence | denotes | Acetylcysteine has also been evaluated for use in the treatment of HIV in two randomized studies [239]. |
| T525 | 740-948 | Sentence | denotes | Although its effect on the viral load was not consistent, the two studies consistently demonstrated that acetylcysteine substantially increased immunological functions and plasma albumin concentrations [239]. |
| T526 | 949-1150 | Sentence | denotes | Furthermore, its free sulfhydryl group cleaves the disulfide bonds in mucoproteins which lowers mucous viscosity in patients with cystic fibrosis or chronic obstructive pulmonary disease [240,241,242]. |
| T527 | 1151-1292 | Sentence | denotes | At higher doses, acetylcysteine can also be used as an antioxidant to mitigate the symptoms of many diseases complicated by oxidative stress. |
| T528 | 1293-1433 | Sentence | denotes | In fact, as a component in the synthesis of the antioxidant glutathione, it may reduce the formation of proinflammatory cytokines [243,244]. |
| T529 | 1434-1592 | Sentence | denotes | Acetylcysteine has also been found to mitigate the oxidative stress and improve the inflammatory response in patients with community acquired pneumonia [245]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2072 | 6-22 | Chemical | denotes | N-Acetylcysteine | |
| 2073 | 24-33 | Chemical | denotes | Acetadote | MESH:D000111 |
| 2093 | 368-376 | Species | denotes | patients | Tax:9606 |
| 2094 | 1065-1073 | Species | denotes | patients | Tax:9606 |
| 2095 | 1543-1551 | Species | denotes | patients | Tax:9606 |
| 2096 | 609-618 | Species | denotes | influenza | Tax:11520 |
| 2097 | 86-105 | Chemical | denotes | cysteine amino acid | |
| 2098 | 133-149 | Chemical | denotes | N-acetylcysteine | |
| 2099 | 251-264 | Chemical | denotes | acetaminophen | MESH:D000082 |
| 2100 | 546-560 | Chemical | denotes | acetylcysteine | MESH:D000111 |
| 2101 | 636-650 | Chemical | denotes | Acetylcysteine | MESH:D000111 |
| 2102 | 845-859 | Chemical | denotes | acetylcysteine | MESH:D000111 |
| 2103 | 1000-1009 | Chemical | denotes | disulfide | MESH:D004220 |
| 2104 | 1168-1182 | Chemical | denotes | acetylcysteine | MESH:D000111 |
| 2105 | 1353-1364 | Chemical | denotes | glutathione | MESH:D005978 |
| 2106 | 1434-1448 | Chemical | denotes | Acetylcysteine | MESH:D000111 |
| 2107 | 265-273 | Disease | denotes | overdose | MESH:D062787 |
| 2108 | 359-367 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2109 | 1079-1094 | Disease | denotes | cystic fibrosis | MESH:D003550 |
| 2110 | 1098-1135 | Disease | denotes | chronic obstructive pulmonary disease | MESH:D029424 |
| 2111 | 1576-1585 | Disease | denotes | pneumonia | MESH:D011014 |