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PMC:7600245 / 65551-66788 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T286 105-114 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T287 115-123 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T288 313-317 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T289 319-324 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T290 330-334 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T291 382-390 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T292 661-666 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T293 779-783 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T294 843-847 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T295 943-948 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T30 313-317 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T31 319-324 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T32 330-334 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 843-847 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T309 484-492 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T310 643-651 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T311 748-756 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T312 848-854 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T313 1183-1191 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T662 105-114 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T663 154-162 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T664 287-293 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T665 313-317 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T666 313-317 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T667 313-317 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T668 313-317 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T669 313-317 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T670 319-324 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T671 319-324 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T672 330-334 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T673 330-334 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T674 520-528 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T675 661-666 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T676 774-783 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero cell
T677 826-832 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T678 843-847 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T679 843-847 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T680 943-948 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T681 1024-1034 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T682 1051-1054 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T683 1072-1073 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T684 1171-1179 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T9195 48-56 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T12773 78-87 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T3099 115-123 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T38887 382-390 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T92042 419-437 Chemical denotes calpain inhibitors http://purl.obolibrary.org/obo/CHEBI_82824
T53518 427-437 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T70302 510-519 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T46598 690-700 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T12103 927-929 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T3501 992-1001 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97654 1161-1170 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T133 463-480 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T134 463-480 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T506 0-5 Sentence denotes 4.14.
T507 6-14 Sentence denotes BLD-2660
T508 15-163 Sentence denotes It an orally bioavailable, small molecule, reversible covalent inhibitor of calpains, non-lysosomal cysteine proteases, with anti-fibrotic activity.
T509 164-335 Sentence denotes BLD-2660 exhibited potent and selective inhibition of calpains 1,2, and 9 and thus was found to be efficacious in multiple animal fibrosis models of skin, liver, and lung.
T510 336-401 Sentence denotes It exhibited high selectivity against related cysteine proteases.
T511 402-505 Sentence denotes Earlier, several calpain inhibitors were found to reduce the viral replication of SARS-CoV-1 [232,233].
T512 506-677 Sentence denotes The antiviral activity by calpain inhibition was also verified using siRNA to selectively silence expression of the calpain 2 isoform in SARS-CoV infected cells [232,233].
T513 678-797 Sentence denotes Undisclosed inhibitors by the developing company were found to reduce SARS-CoV-2 replication in Vero cell-based assays.
T514 798-978 Sentence denotes Furthermore, in preclinical animal models of lung injury and fibrosis, BLD-2660 was shown to reduce the expression/production of IL-6 in injured lungs and to reduce fibrosis [234].
T515 979-1237 Sentence denotes Owing to the antiviral and anti-inflammatory activities of BLD-2660, it has been advanced to a phase 2, randomized, double-blind, placebo-controlled study to evaluate its safety and antiviral activity in COVID-19 hospitalized subjects (NCT04334460; n = 120).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2058 218-237 Gene denotes calpains 1,2, and 9 Gene:823
2059 622-631 Gene denotes calpain 2 Gene:824
2060 927-931 Gene denotes IL-6 Gene:3569
2061 484-492 Species denotes SARS-CoV Tax:694009
2062 748-758 Species denotes SARS-CoV-2 Tax:2697049
2063 164-172 Chemical denotes BLD-2660
2064 294-302 Disease denotes fibrosis MESH:D005355
2065 643-660 Disease denotes SARS-CoV infected MESH:C000657245
2066 843-854 Disease denotes lung injury MESH:D055370
2067 859-867 Disease denotes fibrosis MESH:D005355
2068 963-971 Disease denotes fibrosis MESH:D005355
2069 1183-1191 Disease denotes COVID-19 MESH:C000657245