PMC:7600245 / 61314-62893
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T270 | 39-44 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T271 | 153-158 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T272 | 249-254 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T273 | 817-820 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T274 | 842-845 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T275 | 1141-1145 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T276 | 1183-1191 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T26 | 39-44 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T27 | 153-158 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T28 | 249-254 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T280 | 57-65 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T281 | 171-179 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T282 | 208-216 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T283 | 410-426 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T284 | 475-493 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T285 | 498-533 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T286 | 504-533 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T287 | 641-649 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T288 | 1271-1283 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T289 | 1295-1304 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T290 | 1307-1316 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T291 | 1468-1486 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T292 | 1541-1559 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T631 | 76-79 | http://purl.obolibrary.org/obo/CLO_0001180 | denotes | 203 |
| T632 | 82-83 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T633 | 650-653 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T634 | 756-759 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T635 | 779-780 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T636 | 821-828 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T637 | 861-866 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T638 | 1139-1145 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
| T639 | 1218-1221 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T640 | 1305-1306 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T641 | 1560-1566 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T72674 | 287-291 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T50966 | 375-379 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T9205 | 577-591 | Chemical | denotes | iron chelators | http://purl.obolibrary.org/obo/CHEBI_38157 |
| T89780 | 577-581 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T68757 | 582-591 | Chemical | denotes | chelators | http://purl.obolibrary.org/obo/CHEBI_38161 |
| T62283 | 606-618 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T69571 | 701-710 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T27751 | 731-735 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T37926 | 919-923 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T16477 | 931-943 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T72794 | 1016-1028 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T91637 | 1331-1333 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T161 | 1431-1443 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T89529 | 1523-1532 | Chemical | denotes | bleomycin | http://purl.obolibrary.org/obo/CHEBI_22907 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T115 | 287-303 | http://purl.obolibrary.org/obo/GO_0055072 | denotes | iron homeostasis |
| T116 | 287-303 | http://purl.obolibrary.org/obo/GO_0006879 | denotes | iron homeostasis |
| T117 | 292-303 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T118 | 339-360 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T119 | 375-391 | http://purl.obolibrary.org/obo/GO_0055072 | denotes | iron homeostasis |
| T120 | 375-391 | http://purl.obolibrary.org/obo/GO_0006879 | denotes | iron homeostasis |
| T121 | 380-391 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T122 | 410-426 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T123 | 1271-1283 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T124 | 1336-1345 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T71 | 237-263 | Phenotype | denotes | increase in serum ferritin | http://purl.obolibrary.org/obo/HP_0003281 |
| T72 | 318-334 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T73 | 445-466 | Phenotype | denotes | respiratory illnesses | http://purl.obolibrary.org/obo/HP_0002086 |
| T74 | 475-493 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T75 | 504-524 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T76 | 1468-1486 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T77 | 1541-1559 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T468 | 0-81 | Sentence | denotes | There are reports about unusually high serum ferritin in COVID-19 patients [203]. |
| T469 | 82-232 | Sentence | denotes | A retrospective, multicenter cohort study reported increased levels of serum ferritin in COVID-19 non-survivors compared with COVID-19 survivors [99]. |
| T470 | 233-361 | Sentence | denotes | The increase in serum ferritin indicates dysregulated iron homeostasis pertaining to oxidative stress and inflammatory response. |
| T471 | 362-552 | Sentence | denotes | Dysregulated iron homeostasis may propagate the viral infections leading to severe respiratory illnesses such as pulmonary fibrosis and acute respiratory distress syndrome [204,205,206,207]. |
| T472 | 553-674 | Sentence | denotes | Accordingly, the use of iron chelators, particularly deferoxamine, in managing/treating COVID-19 has been proposed [208]. |
| T473 | 675-889 | Sentence | denotes | Deferoxamine may exert an antiviral effect by depleting iron availability, which has been shown to play a critical role in the replication of RNA viruses such as HCV, HIV, and West Nile virus [209,210,211,212,213]. |
| T474 | 890-996 | Sentence | denotes | In addition to its effect on iron level, deferoxamine also appears to have immunomodulatory effects [209]. |
| T475 | 997-1114 | Sentence | denotes | Along these lines, deferoxamine mitigated the symptoms of Enterovirus-infected mice and decreased the mortality rate. |
| T476 | 1115-1204 | Sentence | denotes | It also upregulated the B cell levels and improved the neutralizing antibody titer [209]. |
| T477 | 1205-1352 | Sentence | denotes | Deferoxamine has also been reported to in vitro block endothelial inflammation induced by influenza A infection by inhibiting IL-6 synthesis [214]. |
| T478 | 1353-1401 | Sentence | denotes | Deferoxamine may also have antifibrotic effects. |
| T479 | 1402-1579 | Sentence | denotes | An intranasal treatment with deferoxamine was reported to prevent pulmonary fibrosis and pulmonary functional decline in bleomycin-induced pulmonary fibrosis animal model [206]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1939 | 1331-1335 | Gene | denotes | IL-6 | Gene:3569 |
| 1940 | 66-74 | Species | denotes | patients | Tax:9606 |
| 1941 | 851-866 | Species | denotes | West Nile virus | Tax:11082 |
| 1942 | 1076-1080 | Species | denotes | mice | Tax:10090 |
| 1943 | 1295-1304 | Species | denotes | influenza | Tax:11520 |
| 1944 | 287-291 | Chemical | denotes | iron | MESH:D007501 |
| 1945 | 375-379 | Chemical | denotes | iron | MESH:D007501 |
| 1946 | 577-581 | Chemical | denotes | iron | MESH:D007501 |
| 1947 | 606-618 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1948 | 675-687 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1949 | 731-735 | Chemical | denotes | iron | MESH:D007501 |
| 1950 | 919-923 | Chemical | denotes | iron | MESH:D007501 |
| 1951 | 931-943 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1952 | 1016-1028 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1953 | 1205-1217 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1954 | 1353-1365 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1955 | 1431-1443 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1956 | 1523-1532 | Chemical | denotes | bleomycin | MESH:D001761 |
| 1957 | 57-65 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1958 | 171-179 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1959 | 208-216 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1960 | 410-426 | Disease | denotes | viral infections | MESH:D001102 |
| 1961 | 445-466 | Disease | denotes | respiratory illnesses | MESH:D012140 |
| 1962 | 475-493 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 1963 | 498-533 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 1964 | 641-649 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1965 | 1055-1075 | Disease | denotes | Enterovirus-infected | MESH:D004769 |
| 1966 | 1099-1108 | Disease | denotes | mortality | MESH:D003643 |
| 1967 | 1271-1283 | Disease | denotes | inflammation | MESH:D007249 |
| 1968 | 1305-1316 | Disease | denotes | A infection | MESH:D007239 |
| 1969 | 1468-1486 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 1970 | 1491-1519 | Disease | denotes | pulmonary functional decline | MESH:D003072 |
| 1971 | 1541-1559 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |