PMC:7600245 / 55136-56488
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T243 | 243-249 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T244 | 511-521 | Body_part | denotes | pyrimidine | http://purl.org/sig/ont/fma/fma82773 |
| T245 | 847-852 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T246 | 873-878 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T247 | 961-969 | Body_part | denotes | tyrosine | http://purl.org/sig/ont/fma/fma82768 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T21 | 243-249 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T243 | 153-173 | Disease | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/MONDO_0008383 |
| T244 | 164-173 | Disease | denotes | arthritis | http://purl.obolibrary.org/obo/MONDO_0005578 |
| T245 | 1040-1054 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T246 | 1283-1291 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T552 | 6-7 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T553 | 209-214 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
| T554 | 218-219 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T555 | 243-249 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T556 | 243-249 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T557 | 243-249 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T558 | 419-420 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T559 | 693-694 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T560 | 711-717 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T561 | 802-810 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T562 | 847-852 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T563 | 861-870 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T564 | 871-878 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T565 | 883-886 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T566 | 941-942 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T567 | 1055-1060 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T568 | 1117-1130 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | tegumentation |
| T569 | 1117-1130 | http://www.ebi.ac.uk/efo/EFO_0000807 | denotes | tegumentation |
| T570 | 1174-1184 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T571 | 1186-1187 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T81195 | 25-33 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T9395 | 41-50 | Chemical | denotes | isoxazole | http://purl.obolibrary.org/obo/CHEBI_35595 |
| T3772 | 51-62 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
| T53954 | 209-214 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T26799 | 290-292 | Chemical | denotes | BK | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T96105 | 378-388 | Chemical | denotes | antivirals | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T88623 | 511-521 | Chemical | denotes | pyrimidine | http://purl.obolibrary.org/obo/CHEBI_16898 |
| T68564 | 571-585 | Chemical | denotes | dihydroorotate | http://purl.obolibrary.org/obo/CHEBI_30867 |
| T83426 | 649-656 | Chemical | denotes | uridine | http://purl.obolibrary.org/obo/CHEBI_16704 |
| T41763 | 678-689 | Chemical | denotes | Leflunomide | http://purl.obolibrary.org/obo/CHEBI_6402 |
| T22133 | 695-702 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
| T57439 | 718-728 | Chemical | denotes | metabolite | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T54596 | 730-744 | Chemical | denotes | isoxazole ring | http://purl.obolibrary.org/obo/CHEBI_52883 |
| T95801 | 730-739 | Chemical | denotes | isoxazole | http://purl.obolibrary.org/obo/CHEBI_35595 |
| T23140 | 754-767 | Chemical | denotes | teriflunomide | http://purl.obolibrary.org/obo/CHEBI_68540 |
| T29149 | 769-776 | Chemical | denotes | Aubagio | http://purl.obolibrary.org/obo/CHEBI_68540 |
| T89479 | 937-939 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T66337 | 961-969 | Chemical | denotes | tyrosine | http://purl.obolibrary.org/obo/CHEBI_18186 |
| T92498 | 990-994 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T91582 | 1081-1083 | Chemical | denotes | BK | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T56250 | 1201-1212 | Chemical | denotes | leflunomide | http://purl.obolibrary.org/obo/CHEBI_6402 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T92 | 522-531 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T93 | 636-645 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T94 | 916-936 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T95 | 916-929 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T96 | 1135-1150 | http://purl.obolibrary.org/obo/GO_0019068 | denotes | virion assembly |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T57 | 153-173 | Phenotype | denotes | rheumatoid arthritis | http://purl.obolibrary.org/obo/HP_0001370 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T411 | 0-86 | Sentence | denotes | It is a synthetic, small molecule and an isoxazole-carboxamide derivative (Figure 8B). |
| T412 | 87-114 | Sentence | denotes | It was approved by the U.S. |
| T413 | 115-188 | Sentence | denotes | FDA in 1998 for the oral treatment of rheumatoid arthritis [173,174,175]. |
| T414 | 189-395 | Sentence | denotes | It is also used off-label as a replacement therapy in kidney transplant recipients with polyomavirus BK [176] and for cytomegalovirus disease in transplant recipients resistant to standard antivirals [177]. |
| T415 | 396-498 | Sentence | denotes | Mechanistically, it is a disease-modifying agent with anti-inflammatory and antiproliferative effects. |
| T416 | 499-677 | Sentence | denotes | It inhibits pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, an important enzyme in the de novo synthesis of uridine monophosphate [178]. |
| T417 | 678-817 | Sentence | denotes | Leflunomide is a prodrug and the active metabolite (isoxazole ring is open: teriflunomide (Aubagio)) is responsible for its activity [179]. |
| T418 | 818-879 | Sentence | denotes | It inhibits rapidly dividing cells such as activated T cells. |
| T419 | 880-943 | Sentence | denotes | It has also been found to block the transcription factor NF-κB. |
| T420 | 944-985 | Sentence | denotes | It also inhibits tyrosine kinase enzymes. |
| T421 | 986-1157 | Sentence | denotes | The drug inhibits the replication of cytomegalovirus, herpes simplex virus 1, and polyomavirus BK by interfering with nucleocapsid tegumentation and virion assembly [179]. |
| T422 | 1158-1352 | Sentence | denotes | Given the above activities, a high dose of leflunomide is being evaluated for the treatment of ambulatory patients with mild COVID-19 at the University of Chicago Medicine (NCT04361214; n = 20). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1720 | 937-942 | Gene | denotes | NF-κB | Gene:4790 |
| 1721 | 1104-1116 | Gene | denotes | nucleocapsid | Gene:43740575 |
| 1722 | 277-292 | Species | denotes | polyomavirus BK | Tax:1891762 |
| 1723 | 1040-1062 | Species | denotes | herpes simplex virus 1 | Tax:10298 |
| 1724 | 1068-1083 | Species | denotes | polyomavirus BK | Tax:1891762 |
| 1725 | 1264-1272 | Species | denotes | patients | Tax:9606 |
| 1726 | 41-62 | Chemical | denotes | isoxazole-carboxamide | |
| 1727 | 511-521 | Chemical | denotes | pyrimidine | MESH:C030986 |
| 1728 | 571-585 | Chemical | denotes | dihydroorotate | MESH:C004768 |
| 1729 | 649-670 | Chemical | denotes | uridine monophosphate | MESH:D014542 |
| 1730 | 678-689 | Chemical | denotes | Leflunomide | MESH:D000077339 |
| 1731 | 730-739 | Chemical | denotes | isoxazole | MESH:D007555 |
| 1732 | 754-767 | Chemical | denotes | teriflunomide | MESH:C527525 |
| 1733 | 769-776 | Chemical | denotes | Aubagio | MESH:C527525 |
| 1734 | 1201-1212 | Chemical | denotes | leflunomide | MESH:D000077339 |
| 1735 | 153-173 | Disease | denotes | rheumatoid arthritis | MESH:D001172 |
| 1736 | 307-330 | Disease | denotes | cytomegalovirus disease | MESH:D003586 |
| 1737 | 1283-1291 | Disease | denotes | COVID-19 | MESH:C000657245 |