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PMC:7600245 / 54155-55109 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T237 92-103 Body_part denotes microtubule http://purl.org/sig/ont/fma/fma63849
T238 170-177 Body_part denotes tubulin http://purl.org/sig/ont/fma/fma67116
T239 261-273 Body_part denotes microtubules http://purl.org/sig/ont/fma/fma63849
T240 393-405 Body_part denotes microtubules http://purl.org/sig/ont/fma/fma63849
T241 457-468 Body_part denotes Microtubule http://purl.org/sig/ont/fma/fma63849
T242 577-585 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T234 231-237 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T235 375-379 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 446-455 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T237 603-611 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T238 614-623 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T239 740-748 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T240 783-818 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T241 789-818 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T242 930-938 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T546 191-194 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T547 295-303 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T548 356-363 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T549 429-436 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T550 672-673 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T551 902-905 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T25991 58-64 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T52649 143-153 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359
T63794 285-294 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T63616 635-639 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T46440 884-894 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T87 92-120 http://purl.obolibrary.org/obo/GO_0007019 denotes microtubule depolymerization
T88 329-363 http://purl.obolibrary.org/obo/GO_0075733 denotes intracellular transport of viruses
T89 329-352 http://purl.obolibrary.org/obo/GO_0046907 denotes intracellular transport
T90 343-352 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T91 457-485 http://purl.obolibrary.org/obo/GO_0007019 denotes Microtubule depolymerization

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T54 231-237 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T55 577-591 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T56 789-809 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T401 0-4 Sentence denotes 4.6.
T402 5-13 Sentence denotes VERU-111
T403 14-187 Sentence denotes It is an orally bioavailable, 3-substituted indole derivative (Figure 8A) and microtubule depolymerization agent that recognizes colchicine-binding site on tubulin subunits.
T404 188-244 Sentence denotes It has been under clinical development for cancer [170].
T405 245-456 Sentence denotes Drugs targeting microtubules have broad antiviral activity because they disrupt the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection.
T406 457-630 Sentence denotes Microtubule depolymerization agents also have strong anti-inflammatory effects that can be beneficial in mitigating the cytokine storm induced by SARS-CoV-2 infection [171].
T407 631-841 Sentence denotes The drug is currently being evaluated in a phase 2 randomized, placebo-controlled study for the treatment of SARS-CoV-2 in patients at elevated risk of acute respiratory distress syndrome (NCT04388826; n = 40).
T408 842-954 Sentence denotes Of note, it is mechanistically similar to colchicine, which has also been considered in COVID-19 patients [172].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1686 375-385 Species denotes SARS CoV-2 Tax:2697049
1687 740-750 Species denotes SARS-CoV-2 Tax:2697049
1688 754-762 Species denotes patients Tax:9606
1689 939-947 Species denotes patients Tax:9606
1690 45-64 Chemical denotes -substituted indole
1691 143-153 Chemical denotes colchicine MESH:D003078
1692 884-894 Chemical denotes colchicine MESH:D003078
1693 231-237 Disease denotes cancer MESH:D009369
1694 446-455 Disease denotes infection MESH:D007239
1695 603-623 Disease denotes SARS-CoV-2 infection MESH:C000657245
1696 783-818 Disease denotes acute respiratory distress syndrome MESH:D012128
1697 930-938 Disease denotes COVID-19 MESH:C000657245