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PMC:7600245 / 49590-52711 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T218 35-37 Body_part denotes AG http://purl.org/sig/ont/fma/fma61898
T219 169-174 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T220 754-764 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T221 771-782 Body_part denotes nucleotides http://purl.org/sig/ont/fma/fma82740
T222 812-817 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T223 850-860 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T224 875-880 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T225 913-918 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T226 1030-1039 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T227 1220-1225 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T228 1447-1450 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T229 1944-1949 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T230 2301-2311 Body_part denotes pyrimidine http://purl.org/sig/ont/fma/fma82773
T231 2318-2329 Body_part denotes nucleotides http://purl.org/sig/ont/fma/fma82740
T232 2731-2734 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T233 2748-2752 Body_part denotes foot http://purl.org/sig/ont/fma/fma9664
T234 2757-2762 Body_part denotes mouth http://purl.org/sig/ont/fma/fma49184
T235 2897-2900 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 2748-2752 Body_part denotes foot http://purl.obolibrary.org/obo/UBERON_0002387
T19 2757-2762 Body_part denotes mouth http://purl.obolibrary.org/obo/UBERON_0000165

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T213 156-182 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T214 184-202 Disease denotes multiple sclerosis http://purl.obolibrary.org/obo/MONDO_0005301
T215 231-250 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T216 578-586 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T217 1074-1086 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T218 1296-1305 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T219 1419-1428 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T220 1523-1531 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T221 1613-1621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T222 1671-1679 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T223 1857-1865 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 2706-2715 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T225 2748-2770 Disease denotes foot-and-mouth disease http://purl.obolibrary.org/obo/MONDO_0005765
T226 2757-2770 Disease denotes mouth disease http://purl.obolibrary.org/obo/MONDO_0006858
T227 2920-2928 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T228 3090-3098 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T493 88-89 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T494 272-273 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T495 404-405 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T496 787-796 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T497 797-798 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T498 812-817 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T499 875-880 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T500 913-918 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T501 1165-1166 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T502 1198-1201 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T503 1220-1225 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T504 1266-1273 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T505 1306-1311 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T506 1342-1350 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T507 1351-1354 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T508 1429-1430 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T509 1431-1436 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T510 1466-1469 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T511 1506-1514 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T512 1682-1690 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T513 1840-1848 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T514 1927-1936 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T515 1944-1949 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T516 2022-2027 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T517 2122-2123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T518 2513-2521 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T519 2584-2587 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T520 2662-2663 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T521 2689-2697 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T522 2716-2723 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T523 2725-2728 http://purl.obolibrary.org/obo/CLO_0001002 denotes 162
T524 2738-2741 http://purl.obolibrary.org/obo/CLO_0001003 denotes 163
T525 2757-2762 http://www.ebi.ac.uk/efo/EFO_0000825 denotes mouth
T526 2771-2776 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T527 2793-2794 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T528 2818-2821 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T529 2837-2845 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T530 2901-2908 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T531 2980-2981 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 2999-3004 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T533 3053-3061 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T714 18-25 Chemical denotes Calcium http://purl.obolibrary.org/obo/CHEBI_22984
T715 35-37 Chemical denotes AG http://purl.obolibrary.org/obo/CHEBI_27569|http://purl.obolibrary.org/obo/CHEBI_40618|http://purl.obolibrary.org/obo/CHEBI_73757
T25593 106-114 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T7933 274-282 Chemical denotes biphenyl http://purl.obolibrary.org/obo/CHEBI_17097
T40831 283-292 Chemical denotes carbamoyl http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_33100
T2210 293-305 Chemical denotes cyclopentene http://purl.obolibrary.org/obo/CHEBI_49155
T4722 646-650 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T60213 672-686 Chemical denotes dihydroorotate http://purl.obolibrary.org/obo/CHEBI_30867
T49164 754-764 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T10698 771-782 Chemical denotes nucleotides http://purl.obolibrary.org/obo/CHEBI_36976
T11341 850-860 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T90920 1043-1045 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T57301 1109-1123 Chemical denotes dihydroorotate http://purl.obolibrary.org/obo/CHEBI_30867
T89861 1174-1183 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T67353 1332-1341 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T28939 1496-1505 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T27522 1830-1839 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T48024 2141-2149 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T51342 2155-2164 Chemical denotes quinoline http://purl.obolibrary.org/obo/CHEBI_17362
T32891 2165-2180 Chemical denotes carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575
T41022 2176-2180 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T40724 2222-2236 Chemical denotes dihydroorotate http://purl.obolibrary.org/obo/CHEBI_30867
T19589 2301-2311 Chemical denotes pyrimidine http://purl.obolibrary.org/obo/CHEBI_16898
T32360 2318-2329 Chemical denotes nucleotides http://purl.obolibrary.org/obo/CHEBI_36976
T11825 2432-2446 Chemical denotes antineoplastic http://purl.obolibrary.org/obo/CHEBI_35610
T78103 2531-2552 Chemical denotes antineoplastic agents http://purl.obolibrary.org/obo/CHEBI_35610
T86303 2579-2583 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T36415 2648-2652 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14871 2679-2688 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T73829 2849-2888 Chemical denotes dihydroorotate dehydrogenase inhibitors http://purl.obolibrary.org/obo/CHEBI_68542
T76979 2849-2863 Chemical denotes dihydroorotate http://purl.obolibrary.org/obo/CHEBI_30867
T66976 2878-2888 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T64357 2953-2957 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T82803 2999-3004 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T84 738-750 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T85 1074-1086 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T86 2285-2297 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T48 156-182 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T49 231-250 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T50 1252-1257 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T369 0-4 Sentence denotes 4.4.
T370 5-71 Sentence denotes Vidofludimus Calcium (Immunic AG, IMU-838) and Brequinar (DuP-785)
T371 72-265 Sentence denotes Vidofludimus is a synthetic small molecule that is under investigation for treating inflammatory bowel disease, multiple sclerosis, and other inflammatory and autoimmune diseases [154,155,156].
T372 266-392 Sentence denotes It is a biphenyl-carbamoyl-cyclopentene derivative (Figure 7) that is being developed as oral formulation for therapeutic use.
T373 393-625 Sentence denotes Currently, a prospective, randomized, multi-center, double-blinded, and placebo-controlled study is ongoing to evaluate the safety and efficacy of vidofludimus as an adjunct therapy in COVID-19 patients (NCT04379271; n = 230) [157].
T374 626-818 Sentence denotes The investigational drug selectively inhibits dihydroorotate dehydrogenase, an important enzyme for the de novo biosynthesis of pyrimidine-based nucleotides, in activated B and T immune cells.
T375 819-939 Sentence denotes Such inhibition diminishes the pyrimidine pool in these cells, which subsequently exposes the cells to metabolic stress.
T376 940-1093 Sentence denotes It also diminishes the release of T helper 1 (Th1) and T helper 17 (Th17) proinflammatory cytokines of IL-17 and IFN-γ, which reduces inflammation [154].
T377 1094-1312 Sentence denotes Interestingly, dihydroorotate dehydrogenase inhibition also results in a direct antiviral effect, which has been exhibited in cells infected with hemorrhagic fever-causing viruses, cytomegalovirus, and influenza virus.
T378 1313-1457 Sentence denotes In fact, IMU-838′s antiviral activity has been demonstrated in vitro against arenavirus, cytomegalovirus, influenza A virus, HCV, and HIV [157].
T379 1458-1540 Sentence denotes IMU-838 has also effectively promoted antiviral activity against SARS-CoV-2 [157].
T380 1541-1624 Sentence denotes Specifically, IMU-838 inhibited the replication of clinical isolates of SARS-CoV-2.
T381 1625-1810 Sentence denotes In cellular assays, IMU-838 promoted the anti-SARS-CoV-2 activity at concentrations lower than those that have been considered in previous and ongoing clinical trials [154,155,156,157].
T382 1811-2098 Sentence denotes Overall, IMU-838′s antiviral activity against SARS-CoV-2 as well as its selective immunomodulatory effect targeting activated immune cells appear to be interesting, particularly that it potentially prevents the virus reactivation that may happen with other immunomodulatory agents [157].
T383 2099-2251 Sentence denotes Likewise, brequinar is a synthetic, small molecule, and quinoline-carboxylic acid derivative (Figure 7) that also inhibits dihydroorotate dehydrogenase.
T384 2252-2340 Sentence denotes It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159].
T385 2341-2400 Sentence denotes Accordingly, brequinar possesses immunosuppressive effects.
T386 2401-2559 Sentence denotes Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160].
T387 2560-2625 Sentence denotes Alternatively, the drug has also antiparasitic effects [160,161].
T388 2626-2783 Sentence denotes More importantly, the drug exhibits a broad-spectrum antiviral activity against influenza viruses [162], HIV-1 [163], and foot-and-mouth disease virus [164].
T389 2784-2937 Sentence denotes In fact, a pre-print under review has documented the activity of dihydroorotate dehydrogenase inhibitors against RNA viruses, including SARS-CoV-2 [165].
T390 2938-3121 Sentence denotes Currently, the drug is being evaluated in a randomized, open-label trial to assess its safety and anti-coronavirus activity in hospitalized adults with COVID-19 (NCT04425252; n = 24).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1556 5-25 Chemical denotes Vidofludimus Calcium
1557 39-46 Chemical denotes IMU-838 MESH:C553728
1566 587-595 Species denotes patients Tax:9606
1567 72-84 Chemical denotes Vidofludimus MESH:C553728
1568 274-305 Chemical denotes biphenyl-carbamoyl-cyclopentene
1569 540-552 Chemical denotes vidofludimus MESH:C553728
1570 156-182 Disease denotes inflammatory bowel disease MESH:D015212
1571 184-202 Disease denotes multiple sclerosis MESH:D009103
1572 231-250 Disease denotes autoimmune diseases MESH:D001327
1573 578-586 Disease denotes COVID-19 MESH:C000657245
1594 672-700 Gene denotes dihydroorotate dehydrogenase Gene:1723
1595 1043-1048 Gene denotes IL-17 Gene:3605
1596 1053-1058 Gene denotes IFN-γ Gene:3458
1597 1109-1137 Gene denotes dihydroorotate dehydrogenase Gene:1723
1598 1296-1311 Species denotes influenza virus Tax:11308
1599 1419-1436 Species denotes influenza A virus Tax:11320
1600 1523-1533 Species denotes SARS-CoV-2 Tax:2697049
1601 1613-1623 Species denotes SARS-CoV-2 Tax:2697049
1602 1857-1867 Species denotes SARS-CoV-2 Tax:2697049
1603 1671-1681 Species denotes SARS-CoV-2 Tax:2697049
1604 754-770 Chemical denotes pyrimidine-based
1605 850-860 Chemical denotes pyrimidine MESH:C030986
1606 1322-1329 Chemical denotes IMU-838 MESH:C553728
1607 1458-1465 Chemical denotes IMU-838 MESH:C553728
1608 1555-1562 Chemical denotes IMU-838 MESH:C553728
1609 1645-1652 Chemical denotes IMU-838 MESH:C553728
1610 1820-1827 Chemical denotes IMU-838 MESH:C553728
1611 1074-1086 Disease denotes inflammation MESH:D007249
1612 1226-1234 Disease denotes infected MESH:D007239
1613 1240-1257 Disease denotes hemorrhagic fever MESH:D006480
1624 2222-2250 Gene denotes dihydroorotate dehydrogenase Gene:1723
1625 2849-2877 Gene denotes dihydroorotate dehydrogenase Gene:1723
1626 2706-2723 Species denotes influenza viruses Tax:11308
1627 2731-2736 Species denotes HIV-1 Tax:11676
1628 2748-2776 Species denotes foot-and-mouth disease virus Tax:12110
1629 2920-2930 Species denotes SARS-CoV-2 Tax:2697049
1630 3041-3052 Species denotes coronavirus Tax:11118
1631 2155-2180 Chemical denotes quinoline-carboxylic acid
1632 2301-2329 Chemical denotes pyrimidine-based nucleotides
1633 3090-3098 Disease denotes COVID-19 MESH:C000657245