PMC:7600245 / 39638-41454
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T164 | 106-114 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T165 | 144-148 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T166 | 156-165 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T167 | 446-449 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T168 | 712-720 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T169 | 1166-1171 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T170 | 1363-1372 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T171 | 1540-1548 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T172 | 1615-1625 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T173 | 1648-1659 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T174 | 1672-1689 | Body_part | denotes | peritoneal cavity | http://purl.org/sig/ont/fma/fma14704 |
| T175 | 1716-1734 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T176 | 1743-1747 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 1166-1171 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T7 | 1672-1689 | Body_part | denotes | peritoneal cavity | http://purl.obolibrary.org/obo/UBERON_0001179 |
| T8 | 1743-1747 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T149 | 498-507 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T150 | 635-643 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T151 | 703-711 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T152 | 1748-1754 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T153 | 1774-1809 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T154 | 1780-1809 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T355 | 45-48 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T356 | 69-70 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T357 | 144-148 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T358 | 197-207 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T359 | 396-404 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T360 | 427-434 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T361 | 450-457 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T362 | 488-493 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T363 | 508-513 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T364 | 554-557 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T365 | 606-607 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T366 | 618-626 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T367 | 876-879 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T368 | 1166-1171 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T369 | 1278-1286 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T370 | 1306-1316 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T371 | 1333-1342 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T372 | 1376-1377 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T373 | 1413-1414 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T374 | 1415-1420 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T375 | 1477-1478 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T376 | 1672-1689 | http://purl.obolibrary.org/obo/UBERON_0001179 | denotes | peritoneal cavity |
| T377 | 1743-1747 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T378 | 1743-1747 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T379 | 1811-1814 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T597 | 106-114 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T598 | 124-131 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T599 | 266-275 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T600 | 305-314 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T601 | 370-380 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T602 | 712-720 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T603 | 765-772 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T604 | 963-974 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T605 | 1227-1237 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T606 | 1562-1564 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T608 | 1716-1734 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T58 | 228-249 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factors |
| T59 | 228-241 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T60 | 823-837 | http://purl.obolibrary.org/obo/GO_0019068 | denotes | viral assembly |
| T61 | 917-931 | http://purl.obolibrary.org/obo/GO_0051168 | denotes | nuclear export |
| T62 | 1014-1035 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factors |
| T63 | 1014-1027 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T64 | 1125-1147 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T65 | 1333-1342 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T66 | 1540-1558 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | cytokine secretion |
| T67 | 1549-1558 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T25 | 1430-1436 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T26 | 1780-1800 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T299 | 0-250 | Sentence | denotes | Considering the current viral pandemic, CRM1 has been put forward as a facilitator of the export of viral proteins from the nucleus of the host cell to the cytoplasm as well as an amplifier of the activities of pro-inflammatory transcription factors. |
| T300 | 251-355 | Sentence | denotes | Thus, the CRM1 inhibitor selinexor may exert relevant antiviral and anti-inflammatory effects [122,123]. |
| T301 | 356-524 | Sentence | denotes | In fact, CRM1 inhibitors have exhibited activity against >20 different viruses, including RNA viruses such as respiratory syncytial virus and influenza virus [122,123]. |
| T302 | 525-652 | Sentence | denotes | Furthermore, CRM1 inhibition has also been identified in in vitro assays to have a potential activity against SARS-CoV-2 [124]. |
| T303 | 653-773 | Sentence | denotes | CRM1 was found to contribute to exporting several SARS-CoV proteins, such as S, N, 9b, Orf3 and Orf6 out of the nucleus. |
| T304 | 774-860 | Sentence | denotes | Thus, CRM1 inhibition is expected to inhibit the viral assembly [125,126,127,128,129]. |
| T305 | 861-1042 | Sentence | denotes | Moreover, CRM1 has also been found to contribute to the nuclear export and functional inactivation of antioxidant, anti-inflammatory, and cytoprotective transcription factors [130]. |
| T306 | 1043-1185 | Sentence | denotes | High levels of CRM1 are found in multiple inflammatory conditions and may magnify inflammatory responses leading to severe organ damage [131]. |
| T307 | 1186-1396 | Sentence | denotes | In this direction, selinexor and similar inhibitors have exhibited potent anti-inflammatory activity by suppressing the activation of NFkB and p38 signaling, leading to reduced cytokines in a variety of models. |
| T308 | 1397-1504 | Sentence | denotes | For example, in a mouse model of sepsis, selinexor increased survival following a lethal dose of endotoxin. |
| T309 | 1505-1690 | Sentence | denotes | Selinexor reduced the inflammatory cytokine secretion of IL-6, TNF-α, and HMGB1 while reducing the numbers of macrophage and polymorphonuclear neutrophils in the mice peritoneal cavity. |
| T310 | 1691-1816 | Sentence | denotes | Selinexor also mitigated lipopolysaccharide-induced lung injury that is similar to acute respiratory distress syndrome [132]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1213 | 40-44 | Gene | denotes | CRM1 | Gene:7514 |
| 1214 | 261-265 | Gene | denotes | CRM1 | Gene:7514 |
| 1215 | 365-369 | Gene | denotes | CRM1 | Gene:7514 |
| 1216 | 538-542 | Gene | denotes | CRM1 | Gene:7514 |
| 1217 | 653-657 | Gene | denotes | CRM1 | Gene:7514 |
| 1218 | 740-744 | Gene | denotes | Orf3 | Gene:136991 |
| 1219 | 780-784 | Gene | denotes | CRM1 | Gene:7514 |
| 1220 | 871-875 | Gene | denotes | CRM1 | Gene:7514 |
| 1221 | 1058-1062 | Gene | denotes | CRM1 | Gene:7514 |
| 1222 | 1329-1332 | Gene | denotes | p38 | Gene:1432 |
| 1223 | 1562-1566 | Gene | denotes | IL-6 | Gene:16193 |
| 1224 | 1568-1573 | Gene | denotes | TNF-α | Gene:21926 |
| 1225 | 1579-1584 | Gene | denotes | HMGB1 | Gene:15289 |
| 1226 | 466-493 | Species | denotes | respiratory syncytial virus | Tax:12814 |
| 1227 | 498-513 | Species | denotes | influenza virus | Tax:11308 |
| 1228 | 635-645 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1229 | 703-711 | Species | denotes | SARS-CoV | Tax:694009 |
| 1230 | 1415-1420 | Species | denotes | mouse | Tax:10090 |
| 1231 | 1667-1671 | Species | denotes | mice | Tax:10090 |
| 1232 | 276-285 | Chemical | denotes | selinexor | MESH:C585161 |
| 1233 | 1205-1214 | Chemical | denotes | selinexor | MESH:C585161 |
| 1234 | 1438-1447 | Chemical | denotes | selinexor | MESH:C585161 |
| 1235 | 1691-1700 | Chemical | denotes | Selinexor | MESH:C585161 |
| 1236 | 1716-1734 | Chemical | denotes | lipopolysaccharide | MESH:D008070 |
| 1237 | 1430-1436 | Disease | denotes | sepsis | MESH:D018805 |
| 1238 | 1743-1754 | Disease | denotes | lung injury | MESH:D055370 |
| 1239 | 1774-1809 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |