PMC:7600245 / 37638-38432
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T140 | 133-136 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T141 | 139-151 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T142 | 160-169 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T143 | 229-234 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T144 | 258-261 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T145 | 273-278 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T146 | 357-360 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T147 | 753-760 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T140 | 475-483 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T340 | 6-7 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T341 | 88-96 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T342 | 208-213 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T343 | 214-217 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T344 | 229-234 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T345 | 273-278 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T346 | 280-283 | http://purl.obolibrary.org/obo/CLO_0001046 | denotes | 116 |
| T347 | 544-545 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T348 | 654-655 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T573 | 38-46 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T574 | 55-57 | Chemical | denotes | S4 | http://purl.obolibrary.org/obo/CHEBI_29401 |
| T575 | 139-151 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T576 | 290-294 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T577 | 368-372 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T578 | 523-532 | Chemical | denotes | maraviroc | http://purl.obolibrary.org/obo/CHEBI_63608 |
| T579 | 556-565 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T580 | 646-650 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T581 | 668-677 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T582 | 753-760 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T280 | 0-285 | Sentence | denotes | It is a small, synthetic, azabicyclic molecule (Figure S4) that exhibits antiretroviral activity by blocking the interaction between HIV-1 glycoprotein 120 and chemokine receptor 5 (C-C motif receptor 5), on human CD4-presenting cells, that is necessary for HIV-1 to enter cells [116]. |
| T281 | 286-319 | Sentence | denotes | The drug was approved by the U.S. |
| T282 | 320-363 | Sentence | denotes | FDA in 2007 as an oral treatment for HIV-1. |
| T283 | 364-494 | Sentence | denotes | The drug is currently being evaluated in three clinical trials (NCT04441385, NCT04435522, and NCT04475991) for COVID-19 treatment. |
| T284 | 495-580 | Sentence | denotes | Recently, it was shown that maraviroc may act as a potential inhibitor of Mpro [117]. |
| T285 | 581-794 | Sentence | denotes | However, it appears that it is more realistic to assume that the drug is a viral entry inhibitor and potentially acts by blocking the interaction between the viral spike S protein and the host ACE2 receptor [118]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1132 | 160-180 | Gene | denotes | chemokine receptor 5 | Gene:1234 |
| 1133 | 214-217 | Gene | denotes | CD4 | Gene:920 |
| 1134 | 774-778 | Gene | denotes | ACE2 | Gene:59272 |
| 1135 | 569-573 | Gene | denotes | Mpro | Gene:8673700 |
| 1136 | 133-138 | Species | denotes | HIV-1 | Tax:11676 |
| 1137 | 208-213 | Species | denotes | human | Tax:9606 |
| 1138 | 258-263 | Species | denotes | HIV-1 | Tax:11676 |
| 1139 | 357-362 | Species | denotes | HIV-1 | Tax:11676 |
| 1140 | 523-532 | Chemical | denotes | maraviroc | MESH:D000077592 |
| 1141 | 475-483 | Disease | denotes | COVID-19 | MESH:C000657245 |