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PMC:7600245 / 34856-36048 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T135 85-88 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T136 674-679 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T137 708-713 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T138 732-741 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T129 469-477 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T130 478-487 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T131 652-660 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 1123-1131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T313 635-643 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T314 666-679 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T315 681-686 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T316 687-697 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T317 708-713 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T318 715-719 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T319 715-719 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T320 715-719 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T321 715-719 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T322 715-719 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T323 715-719 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T324 715-719 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T325 715-719 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T326 726-731 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T327 732-741 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T328 782-785 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T329 978-983 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T330 1039-1040 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T331 1098-1099 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 1144-1145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T527 48-52 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T528 91-100 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T531 230-240 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T532 387-389 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T533 395-416 Chemical denotes neuroprotective agent http://purl.obolibrary.org/obo/CHEBI_63726
T534 434-447 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T535 532-541 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T536 569-573 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T537 603-612 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T538 771-781 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T539 805-814 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T540 828-832 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T541 904-913 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T542 939-948 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T543 954-958 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T544 1007-1009 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T546 1071-1081 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T547 1110-1119 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T548 1172-1185 Chemical denotes nucleic acids http://purl.obolibrary.org/obo/CHEBI_33696
T549 1180-1185 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T256 0-110 Sentence denotes Atazanavir (Figure 6) is another antiretroviral drug that competitively inhibits the HIV-1 aspartate protease.
T257 111-154 Sentence denotes Atazanavir was approved in 2003 by the U.S.
T258 155-301 Sentence denotes FDA and usually prescribed in combination with the pharmacokinetic booster cobicistat (combination is being marketed under the name Evotaz; 2015).
T259 302-564 Sentence denotes Currently, it is being evaluated alone (NCT04468087; n = 189) or in combination with NA-831 (neuroprotective agent; traneurocin) or dexamethasone for the treatment of COVID-19 infection (NCT04452565; n = 525) or with nitazoxanide/ritonavir (NCT04459286; n = 98).
T260 565-752 Sentence denotes The drug alone or in combination with ritonavir demonstrated in vitro activity against SARS-CoV-2 in Vero E6 cells, human epithelial pulmonary cells (A549), and human monocytes [109,110].
T261 753-823 Sentence denotes In these studies, atazanavir has been identified as inhibitor of Mpro.
T262 824-949 Sentence denotes The drug and its combination have been projected to be 10-fold more potent than lopinavir and its combination with ritonavir.
T263 950-1035 Sentence denotes The drug also inhibited the virus-induced enhancement of IL-6 and TNF-α levels [109].
T264 1036-1192 Sentence denotes In a separate computational study, atazanavir was reported as a potential inhibitor of SARS-CoV-2 helicase, a viral enzyme that unwinds nucleic acids [111].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1052 1007-1011 Gene denotes IL-6 Gene:3569
1053 1016-1021 Gene denotes TNF-α Gene:7124
1054 818-822 Gene denotes Mpro Gene:8673700
1055 85-90 Species denotes HIV-1 Tax:11676
1056 652-662 Species denotes SARS-CoV-2 Tax:2697049
1057 681-686 Species denotes human Tax:9606
1058 726-731 Species denotes human Tax:9606
1059 1123-1133 Species denotes SARS-CoV-2 Tax:2697049
1060 0-10 Chemical denotes Atazanavir MESH:D000069446
1061 91-100 Chemical denotes aspartate MESH:D001224
1062 111-121 Chemical denotes Atazanavir MESH:D000069446
1063 230-240 Chemical denotes cobicistat MESH:D000069547
1064 287-293 Chemical denotes Evotaz
1065 387-393 Chemical denotes NA-831
1066 418-429 Chemical denotes traneurocin
1067 434-447 Chemical denotes dexamethasone MESH:D003907
1068 519-541 Chemical denotes nitazoxanide/ritonavir
1069 603-612 Chemical denotes ritonavir MESH:D019438
1070 771-781 Chemical denotes atazanavir MESH:D000069446
1071 904-913 Chemical denotes lopinavir MESH:D061466
1072 939-948 Chemical denotes ritonavir MESH:D019438
1073 1071-1081 Chemical denotes atazanavir MESH:D000069446
1074 469-477 Disease denotes COVID-19 MESH:C000657245
1075 478-487 Disease denotes infection MESH:D007239
1076 671-673 CellLine denotes E6 CVCL:4582
1077 715-719 CellLine denotes A549 CVCL:0023