PMC:7600245 / 26472-27992
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T108 | 180-202 | Body_part | denotes | gastrointestinal tract | http://purl.org/sig/ont/fma/fma71132 |
| T109 | 287-294 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T110 | 451-454 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T111 | 795-801 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
| T112 | 805-808 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T113 | 1192-1196 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T114 | 1373-1376 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T115 | 1428-1444 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T116 | 1439-1444 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T99 | 474-483 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T100 | 485-490 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T101 | 492-522 | Disease | denotes | Venezuelan equine encephalitis | http://purl.obolibrary.org/obo/MONDO_0006005 |
| T102 | 510-522 | Disease | denotes | encephalitis | http://purl.obolibrary.org/obo/MONDO_0019956 |
| T103 | 540-548 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T104 | 550-558 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T105 | 1115-1123 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T241 | 85-88 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T242 | 180-202 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | gastrointestinal tract |
| T243 | 341-347 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T244 | 395-398 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T245 | 399-400 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T246 | 426-434 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T247 | 455-462 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T248 | 503-509 | http://purl.obolibrary.org/obo/NCBITaxon_9796 | denotes | equine |
| T249 | 523-528 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T250 | 597-600 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
| T251 | 671-672 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T252 | 758-764 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T253 | 809-816 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T254 | 902-908 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T255 | 1176-1181 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T256 | 1415-1420 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T257 | 1421-1427 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
| T258 | 1428-1438 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T259 | 1439-1444 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T260 | 1481-1482 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T261 | 1503-1504 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T370 | 10-19 | Chemical | denotes | isopropyl | http://purl.obolibrary.org/obo/CHEBI_30353 |
| T371 | 20-25 | Chemical | denotes | ester | http://purl.obolibrary.org/obo/CHEBI_35701 |
| T372 | 26-33 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
| T373 | 77-84 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
| T374 | 158-172 | Chemical | denotes | hydroxyl group | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T375 | 158-166 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191 |
| T376 | 167-172 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T377 | 348-360 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T378 | 416-425 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T379 | 582-587 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T380 | 714-724 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T381 | 942-944 | Chemical | denotes | 5B | http://purl.obolibrary.org/obo/CHEBI_27560 |
| T382 | 951-956 | Chemical | denotes | oxime | http://purl.obolibrary.org/obo/CHEBI_25750 |
| T383 | 975-982 | Chemical | denotes | uridine | http://purl.obolibrary.org/obo/CHEBI_16704 |
| T384 | 998-1007 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T385 | 1041-1049 | Chemical | denotes | cytidine | http://purl.obolibrary.org/obo/CHEBI_17562 |
| T386 | 1065-1074 | Chemical | denotes | guanosine | http://purl.obolibrary.org/obo/CHEBI_16750 |
| T387 | 1382-1386 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T388 | 1450-1454 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T46 | 132-147 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T47 | 309-324 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T16 | 510-522 | Phenotype | denotes | encephalitis | http://purl.obolibrary.org/obo/HP_0002383 |
| T17 | 1197-1208 | Phenotype | denotes | weight loss | http://purl.obolibrary.org/obo/HP_0001824 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T193 | 0-72 | Sentence | denotes | It is the isopropyl-ester prodrug of β-D-N4-hydroxycytidine (Figure 5A). |
| T194 | 73-203 | Sentence | denotes | The prodrug has improved oral bioavailability as it avoids phosphorylation of the N4-hydroxyl group in the gastrointestinal tract. |
| T195 | 204-366 | Sentence | denotes | It is hydrolyzed in vivo to release the parent (EIDD-1931), which distributes into tissues, and upon tri-phosphorylation, it becomes the active triphosphate form. |
| T196 | 367-623 | Sentence | denotes | The tri-phosphorylated form has a broad-spectrum antiviral activity against various RNA viruses, including influenza, Ebola, Venezuelan equine encephalitis virus, MERS-CoV, SARS-CoV, SARS-CoV-2 and related zoonotic group 2b or 2c bat coronaviruses [80,81]. |
| T197 | 624-730 | Sentence | denotes | It also demonstrated increased potency against a coronavirus with resistance mutations to remdesivir [82]. |
| T198 | 731-897 | Sentence | denotes | By the action of RdRp, the active form is incorporated into the genome of RNA viruses, leading to the accumulation of mutations known as viral error catastrophe [80]. |
| T199 | 898-1080 | Sentence | denotes | The active form exists in two forms (Figure 5B): the oxime form which mimics uridine and pairs with adenosine, while the other tautomer mimics cytidine and pairs with guanosine [81]. |
| T200 | 1081-1248 | Sentence | denotes | In mice infected with MERS-CoV or SARS-CoV, EIDD-2801 administration was found to diminish the virus titer and body weight loss and to improve pulmonary function [80]. |
| T201 | 1249-1377 | Sentence | denotes | Reduced MERS-CoV yields in vitro and in vivo was because of the increase in transition mutation frequency in only the viral RNA. |
| T202 | 1378-1445 | Sentence | denotes | The drug produced similar results in human airway epithelial cells. |
| T203 | 1446-1520 | Sentence | denotes | The drug showed similar results as a prophylactic and as a treatment [80]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 761 | 748-752 | Gene | denotes | RdRp | Gene:43740578 |
| 762 | 485-490 | Species | denotes | Ebola | Tax:1570291 |
| 763 | 492-528 | Species | denotes | Venezuelan equine encephalitis virus | Tax:11036 |
| 764 | 530-538 | Species | denotes | MERS-CoV | Tax:1335626 |
| 765 | 540-548 | Species | denotes | SARS-CoV | Tax:694009 |
| 766 | 550-560 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 767 | 601-614 | Species | denotes | coronaviruses | Tax:11118 |
| 768 | 673-684 | Species | denotes | coronavirus | Tax:11118 |
| 769 | 1084-1088 | Species | denotes | mice | Tax:10090 |
| 770 | 1103-1111 | Species | denotes | MERS-CoV | Tax:1335626 |
| 771 | 1115-1123 | Species | denotes | SARS-CoV | Tax:694009 |
| 772 | 1257-1265 | Species | denotes | MERS-CoV | Tax:1335626 |
| 773 | 1415-1420 | Species | denotes | human | Tax:9606 |
| 774 | 474-483 | Species | denotes | influenza | Tax:11520 |
| 775 | 10-25 | Chemical | denotes | isopropyl-ester | |
| 776 | 37-59 | Chemical | denotes | β-D-N4-hydroxycytidine | MESH:C010737 |
| 777 | 348-360 | Chemical | denotes | triphosphate | MESH:C005692 |
| 778 | 714-724 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 779 | 951-956 | Chemical | denotes | oxime | MESH:D010091 |
| 780 | 975-982 | Chemical | denotes | uridine | MESH:D014529 |
| 781 | 998-1007 | Chemical | denotes | adenosine | MESH:D000241 |
| 782 | 1041-1049 | Chemical | denotes | cytidine | MESH:D003562 |
| 783 | 1065-1074 | Chemical | denotes | guanosine | MESH:D006151 |
| 784 | 573-581 | Disease | denotes | zoonotic | MESH:D015047 |
| 785 | 868-891 | Disease | denotes | viral error catastrophe | |
| 786 | 1089-1097 | Disease | denotes | infected | MESH:D007239 |
| 787 | 1197-1208 | Disease | denotes | weight loss | MESH:D015431 |