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PMC:7600245 / 20634-21986 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T91 54-61 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T92 76-86 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T93 183-186 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T94 306-311 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 517-527 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T96 577-582 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T77 808-817 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 1157-1165 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T79 1168-1177 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80 1310-1318 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T188 110-120 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T189 130-131 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T190 221-231 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T191 306-311 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T192 315-316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 386-388 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T194 386-388 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T195 517-527 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T196 517-527 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T197 577-582 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T198 949-953 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T199 1056-1060 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T200 1122-1123 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T201 1200-1201 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T268 10-31 Chemical denotes tenofovir alafenamide http://purl.obolibrary.org/obo/CHEBI_90926
T269 10-19 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716
T272 33-40 Chemical denotes Vemlidy http://purl.obolibrary.org/obo/CHEBI_90923
T273 54-61 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T274 76-86 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T275 144-153 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T276 183-186 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T277 239-243 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T278 367-377 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T279 386-388 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T280 422-429 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T281 454-461 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T282 877-890 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T283 892-899 Chemical denotes Descovy http://purl.obolibrary.org/obo/CHEBI_133007
T284 924-937 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T285 956-969 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T286 974-985 Chemical denotes rilpivirine http://purl.obolibrary.org/obo/CHEBI_68606
T287 987-994 Chemical denotes Odefsey http://purl.obolibrary.org/obo/CHEBI_133010
T288 1007-1016 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T289 1017-1027 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T290 1032-1045 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T291 1079-1092 Chemical denotes emtricitabine http://purl.obolibrary.org/obo/CHEBI_31536
T292 1097-1118 Chemical denotes tenofovir alafenamide http://purl.obolibrary.org/obo/CHEBI_90926
T293 1097-1106 Chemical denotes tenofovir http://purl.obolibrary.org/obo/CHEBI_134504|http://purl.obolibrary.org/obo/CHEBI_63625|http://purl.obolibrary.org/obo/CHEBI_63716

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 165-178 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T40 165-178 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T152 0-216 Sentence denotes Likewise, tenofovir alafenamide (Vemlidy; 2016) is an adenine-based acyclic nucleotide analog that, following activation, acts as a competitive inhibitor of reverse transcriptase and DNA chain elongation termination.
T153 217-395 Sentence denotes The activation of the drug is, however, different and it usually takes place in infected cells by a series of bio-transformations similar to those of remdesivir (Figure S2) [67].
T154 396-612 Sentence denotes The main advantage of the prodrug, relative to the former prodrug, is that it increases the drug’s oral bioavailability, intestinal diffusion, selectivity of targeting the infected cells, and intracellular half-life.
T155 613-694 Sentence denotes It also decreases the potential renal toxicity of the monophosphate intermediate.
T156 695-755 Sentence denotes Tenofovir alafenamide was first approved in 2016 by the U.S.
T157 756-823 Sentence denotes FDA and is prescribed for the oral treatment of HBV infection [68].
T158 824-1062 Sentence denotes It is also available in many other combinations with emtricitabine (Descovy; 2016), bictegravir and emtricitabine (Biktarvy; 2018), emtricitabine and rilpivirine (Odefsey; 2016), and darunavir/cobicistat and emtricitabine (Symtuza; 2018).
T159 1063-1352 Sentence denotes The efficacy of emtricitabine and tenofovir alafenamide as a prophylactic combination against SARS-CoV-2 infection is being evaluated in a large randomized, double-blind, controlled with placebo clinical trial for health care providers exposed to COVID-19 patients (NCT04405271; n = 1378).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
564 1319-1327 Species denotes patients Tax:9606
565 10-31 Chemical denotes tenofovir alafenamide MESH:C442442
566 54-61 Chemical denotes adenine MESH:D000225
567 367-377 Chemical denotes remdesivir MESH:C000606551
568 667-680 Chemical denotes monophosphate
569 695-716 Chemical denotes Tenofovir alafenamide MESH:C442442
570 877-890 Chemical denotes emtricitabine MESH:D000068679
571 908-919 Chemical denotes bictegravir MESH:C000620396
572 924-937 Chemical denotes emtricitabine MESH:D000068679
573 956-969 Chemical denotes emtricitabine MESH:D000068679
574 974-985 Chemical denotes rilpivirine MESH:D000068696
575 1007-1016 Chemical denotes darunavir MESH:D000069454
576 1017-1027 Chemical denotes cobicistat MESH:D000069547
577 1032-1045 Chemical denotes emtricitabine MESH:D000068679
578 1079-1092 Chemical denotes emtricitabine MESH:D000068679
579 1097-1118 Chemical denotes tenofovir alafenamide MESH:C442442
580 297-305 Disease denotes infected MESH:D007239
581 568-576 Disease denotes infected MESH:D007239
582 645-659 Disease denotes renal toxicity MESH:D007674
583 804-817 Disease denotes HBV infection MESH:D006509
584 1157-1177 Disease denotes SARS-CoV-2 infection MESH:C000657245
585 1310-1318 Disease denotes COVID-19 MESH:C000657245