HTS has been productive in drug design [204,205], but the method is time and resource intensive [206] and expensive [206] because of the numerous molecules to be examined (~100 million) [207]. Furthermore, the success rate is only estimated to be at ~50% [204,208]. Unlike traditional HTS, which can survey a large number of molecules ranging from a few hundred thousand to a few million [209], FBDD usually surveys a few thousand molecules (~1000–15000) from libraries with greater chemical diversity [209,210]. FBDD is a main-stream screening technique for drug discovery [207,209,211,212,213,214,215,216] and NMR is standard for many FBDD studies [209]. Additional methods and techniques such as SPR, X-ray crystallography [209,217,218,219,220] etc. have also been used in FBDD studies, accompanied or unaccompanied by NMR experiments. For examples of FBDD derived drugs using methods besides NMR, refer to Table 2.