PMC:7594251 / 115739-132613 JSON TXT

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LitCovid_Glycan-Motif-Structure

Id	Subject	Object	Predicate	Lexical cue
T1	5555-5562	https://glytoucan.org/Structures/Glycans/G15021LG	denotes	glucose
T2	5643-5650	https://glytoucan.org/Structures/Glycans/G15021LG	denotes	glucose
T3	8056-8063	https://glytoucan.org/Structures/Glycans/G15021LG	denotes	glucose
T4	12119-12126	https://glytoucan.org/Structures/Glycans/G15021LG	denotes	glucose
T5	12222-12229	https://glytoucan.org/Structures/Glycans/G15021LG	denotes	glucose

LitCovid-PD-FMA-UBERON

Id	Subject	Object	Predicate	Lexical cue	fma_id
T75	1429-1434	Body_part	denotes	Orbit	http://purl.org/sig/ont/fma/fma54379
T76	2009-2025	Body_part	denotes	transverse plane	http://purl.org/sig/ont/fma/fma71928
T77	2135-2151	Body_part	denotes	transverse plane	http://purl.org/sig/ont/fma/fma71928
T78	2186-2190	Body_part	denotes	axis	http://purl.org/sig/ont/fma/fma12520
T79	4137-4141	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T80	4181-4185	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T81	4216-4220	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T82	4251-4255	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T83	4627-4629	Body_part	denotes	CS	http://purl.org/sig/ont/fma/fma284995
T84	5431-5441	Body_part	denotes	tryptophan	http://purl.org/sig/ont/fma/fma82767
T85	5530-5535	Body_part	denotes	serum	http://purl.org/sig/ont/fma/fma63083
T86	5537-5544	Body_part	denotes	alanine	http://purl.org/sig/ont/fma/fma82749
T87	5555-5562	Body_part	denotes	glucose	http://purl.org/sig/ont/fma/fma82743
T88	5564-5573	Body_part	denotes	glutamine	http://purl.org/sig/ont/fma/fma82752
T89	5588-5595	Body_part	denotes	leucine	http://purl.org/sig/ont/fma/fma82757
T90	5616-5623	Body_part	denotes	alanine	http://purl.org/sig/ont/fma/fma82749
T91	5643-5650	Body_part	denotes	glucose	http://purl.org/sig/ont/fma/fma82743
T92	5652-5659	Body_part	denotes	glycine	http://purl.org/sig/ont/fma/fma82753
T93	5898-5908	Body_part	denotes	amino acid	http://purl.org/sig/ont/fma/fma82739
T94	6461-6466	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T95	6503-6512	Body_part	denotes	glutamine	http://purl.org/sig/ont/fma/fma82752
T96	6530-6536	Body_part	denotes	plasma	http://purl.org/sig/ont/fma/fma62970
T97	6633-6637	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T98	6736-6750	Body_part	denotes	cell membranes	http://purl.org/sig/ont/fma/fma63841
T99	6736-6740	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T100	7062-7068	Body_part	denotes	breast	http://purl.org/sig/ont/fma/fma9601
T101	7289-7294	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T102	7368-7372	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T103	7718-7728	Body_part	denotes	fatty acid	http://purl.org/sig/ont/fma/fma82738
T104	7879-7882	Body_part	denotes	DNA	http://purl.org/sig/ont/fma/fma74412
T105	7992-7997	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T106	8056-8063	Body_part	denotes	glucose	http://purl.org/sig/ont/fma/fma82743
T107	8079-8086	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T108	8094-8099	Body_part	denotes	liver	http://purl.org/sig/ont/fma/fma7197
T109	8608-8613	Body_part	denotes	serum	http://purl.org/sig/ont/fma/fma63083
T110	8837-8842	Body_part	denotes	lipid	http://purl.org/sig/ont/fma/fma67264
T111	8915-8921	Body_part	denotes	kidney	http://purl.org/sig/ont/fma/fma7203
T112	8923-8928	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T113	8962-8966	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T114	9015-9020	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T115	9022-9027	Body_part	denotes	lipid	http://purl.org/sig/ont/fma/fma67264
T116	9311-9316	Body_part	denotes	lipid	http://purl.org/sig/ont/fma/fma67264
T117	9513-9524	Body_part	denotes	myoinositol	http://purl.org/sig/ont/fma/fma82800
T118	9528-9533	Body_part	denotes	serum	http://purl.org/sig/ont/fma/fma63083
T119	9710-9724	Body_part	denotes	nervous system	http://purl.org/sig/ont/fma/fma7157
T120	9759-9762	Body_part	denotes	gut	http://purl.org/sig/ont/fma/fma7199
T121	9956-9966	Body_part	denotes	amino acid	http://purl.org/sig/ont/fma/fma82739
T122	10195-10200	Body_part	denotes	brain	http://purl.org/sig/ont/fma/fma50801
T123	10201-10207	Body_part	denotes	tissue	http://purl.org/sig/ont/fma/fma9637
T124	10236-10243	Body_part	denotes	neurons	http://purl.org/sig/ont/fma/fma54527
T125	10265-10272	Body_part	denotes	glycine	http://purl.org/sig/ont/fma/fma82753
T126	10339-10344	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T127	10619-10638	Body_part	denotes	cerebrospinal fluid	http://purl.org/sig/ont/fma/fma20935
T128	10805-10815	Body_part	denotes	amino acid	http://purl.org/sig/ont/fma/fma82739
T129	11344-11349	Body_part	denotes	blood	http://purl.org/sig/ont/fma/fma9670
T130	11568-11578	Body_part	denotes	fatty acid	http://purl.org/sig/ont/fma/fma82738
T131	11612-11622	Body_part	denotes	amino acid	http://purl.org/sig/ont/fma/fma82739
T132	11873-11876	Body_part	denotes	gut	http://purl.org/sig/ont/fma/fma7199
T133	12119-12126	Body_part	denotes	glucose	http://purl.org/sig/ont/fma/fma82743
T134	12222-12229	Body_part	denotes	glucose	http://purl.org/sig/ont/fma/fma82743
T135	12997-13000	Body_part	denotes	ITD	http://purl.org/sig/ont/fma/fma58066
T136	14884-14886	Body_part	denotes	CS	http://purl.org/sig/ont/fma/fma284995
T137	15591-15598	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T138	15829-15833	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T139	15891-15901	Body_part	denotes	cell parts	http://purl.org/sig/ont/fma/fma78563
T140	15891-15895	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T141	16022-16029	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257
T142	16098-16105	Body_part	denotes	Protein	http://purl.org/sig/ont/fma/fma67257
T143	16183-16191	Body_part	denotes	proteins	http://purl.org/sig/ont/fma/fma67257
T144	16454-16461	Body_part	denotes	protein	http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T37	5530-5535	Body_part	denotes	serum	http://purl.obolibrary.org/obo/UBERON_0001977
T38	5791-5796	Body_part	denotes	Shell	http://purl.obolibrary.org/obo/UBERON_0006612
T39	7062-7068	Body_part	denotes	breast	http://purl.obolibrary.org/obo/UBERON_0000310
T40	8094-8099	Body_part	denotes	liver	http://purl.obolibrary.org/obo/UBERON_0002107
T41	8608-8613	Body_part	denotes	serum	http://purl.obolibrary.org/obo/UBERON_0001977
T42	8915-8921	Body_part	denotes	kidney	http://purl.obolibrary.org/obo/UBERON_0002113
T43	9528-9533	Body_part	denotes	serum	http://purl.obolibrary.org/obo/UBERON_0001977
T44	9710-9724	Body_part	denotes	nervous system	http://purl.obolibrary.org/obo/UBERON_0001016
T45	10195-10200	Body_part	denotes	brain	http://purl.obolibrary.org/obo/UBERON_0000955
T46	10201-10207	Body_part	denotes	tissue	http://purl.obolibrary.org/obo/UBERON_0000479
T47	10619-10638	Body_part	denotes	cerebrospinal fluid	http://purl.obolibrary.org/obo/UBERON_0001359
T48	11344-11349	Body_part	denotes	blood	http://purl.obolibrary.org/obo/UBERON_0000178
T49	15891-15901	Body_part	denotes	cell parts	http://purl.obolibrary.org/obo/UBERON_0000470

LitCovid-PD-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T122	3078-3081	Disease	denotes	STD	http://purl.obolibrary.org/obo/MONDO_0021681
T123	3836-3838	Disease	denotes	SE	http://purl.obolibrary.org/obo/MONDO_0002125
T124	4591-4594	Disease	denotes	MDD	http://purl.obolibrary.org/obo/MONDO_0012048\|http://purl.obolibrary.org/obo/MONDO_0016217
T126	4707-4710	Disease	denotes	STD	http://purl.obolibrary.org/obo/MONDO_0021681
T127	6626-6632	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T128	7062-7075	Disease	denotes	breast cancer	http://purl.obolibrary.org/obo/MONDO_0007254
T129	7069-7075	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T130	8324-8344	Disease	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/MONDO_0008383
T131	8335-8344	Disease	denotes	arthritis	http://purl.obolibrary.org/obo/MONDO_0005578
T132	8736-8744	Disease	denotes	epilepsy	http://purl.obolibrary.org/obo/MONDO_0005027
T133	8870-8884	Disease	denotes	ovarian cancer	http://purl.obolibrary.org/obo/MONDO_0008170
T134	8878-8884	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T135	9549-9552	Disease	denotes	CRC	http://purl.obolibrary.org/obo/MONDO_0005575\|http://purl.obolibrary.org/obo/MONDO_0024331
T137	9554-9571	Disease	denotes	colorectal cancer	http://purl.obolibrary.org/obo/MONDO_0005575
T138	9565-9571	Disease	denotes	cancer	http://purl.obolibrary.org/obo/MONDO_0004992
T139	10642-10664	Disease	denotes	tuberculous meningitis	http://purl.obolibrary.org/obo/MONDO_0044684
T140	10654-10664	Disease	denotes	meningitis	http://purl.obolibrary.org/obo/MONDO_0004796\|http://purl.obolibrary.org/obo/MONDO_0021108
T142	11073-11095	Disease	denotes	gastric adenocarcinoma	http://purl.obolibrary.org/obo/MONDO_0005036
T143	11081-11095	Disease	denotes	adenocarcinoma	http://purl.obolibrary.org/obo/MONDO_0004970
T144	14667-14670	Disease	denotes	MDD	http://purl.obolibrary.org/obo/MONDO_0012048\|http://purl.obolibrary.org/obo/MONDO_0016217
T146	15600-15603	Disease	denotes	STD	http://purl.obolibrary.org/obo/MONDO_0021681
T147	16399-16402	Disease	denotes	HTS	http://purl.obolibrary.org/obo/MONDO_0011549

LitCovid-PD-CLO

Id	Subject	Object	Predicate	Lexical cue
T142	152-153	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T143	366-375	http://purl.obolibrary.org/obo/OBI_0000245	denotes	organized
T144	892-899	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	viruses
T145	2038-2040	http://purl.obolibrary.org/obo/CLO_0007874	denotes	ms
T146	2060-2067	http://www.ebi.ac.uk/efo/EFO_0000876	denotes	extreme
T147	2239-2240	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T148	2272-2273	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T149	2286-2288	http://purl.obolibrary.org/obo/CLO_0050160	denotes	T2
T150	2339-2340	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T151	2427-2428	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T152	2636-2637	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T153	2648-2654	http://purl.obolibrary.org/obo/SO_0000418	denotes	signal
T154	2732-2733	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T155	2779-2780	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T156	3043-3050	http://purl.obolibrary.org/obo/SO_0000418	denotes	signals
T157	3087-3088	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T158	3106-3107	http://purl.obolibrary.org/obo/CLO_0001021	denotes	b
T159	3305-3306	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T160	3322-3323	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T161	3432-3434	http://purl.obolibrary.org/obo/CLO_0053733	denotes	11
T162	3500-3501	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T163	3524-3525	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T164	3884-3887	http://purl.obolibrary.org/obo/CLO_0001230	denotes	293
T165	3884-3887	http://purl.obolibrary.org/obo/CLO_0037237	denotes	293
T166	3884-3887	http://purl.obolibrary.org/obo/CLO_0050903	denotes	293
T167	3884-3887	http://purl.obolibrary.org/obo/CLO_0054249	denotes	293
T168	3884-3887	http://purl.obolibrary.org/obo/CLO_0054250	denotes	293
T169	3884-3887	http://purl.obolibrary.org/obo/CLO_0054251	denotes	293
T170	3884-3887	http://purl.obolibrary.org/obo/CLO_0054252	denotes	293
T171	3960-3962	http://purl.obolibrary.org/obo/CLO_0003414	denotes	G2
T172	4137-4141	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T173	4159-4160	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T174	4181-4185	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T175	4192-4193	http://purl.obolibrary.org/obo/CLO_0001021	denotes	B
T176	4216-4220	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T177	4251-4255	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T178	4295-4302	http://purl.obolibrary.org/obo/CLO_0007225	denotes	labeled
T179	4641-4650	http://purl.obolibrary.org/obo/SO_0000418	denotes	Signaling
T180	4772-4773	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T181	4883-4891	http://purl.obolibrary.org/obo/CLO_0001658	denotes	Activity
T182	5040-5046	http://purl.obolibrary.org/obo/UBERON_0000473	denotes	Tested
T183	5356-5357	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T184	5503-5505	http://purl.obolibrary.org/obo/PR_000005794	denotes	CP
T185	5839-5840	http://purl.obolibrary.org/obo/CLO_0001020	denotes	A
T186	6084-6092	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membrane
T187	6163-6165	http://purl.obolibrary.org/obo/PR_000005794	denotes	CP
T188	6168-6170	http://purl.obolibrary.org/obo/CLO_0001527	denotes	94
T189	6461-6466	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T190	6530-6536	http://purl.obolibrary.org/obo/UBERON_0001969	denotes	plasma
T191	6633-6637	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T192	6639-6645	http://purl.obolibrary.org/obo/CLO_0009063	denotes	Skov-3
T193	6639-6645	http://purl.obolibrary.org/obo/CLO_0052004	denotes	Skov-3
T194	6639-6645	http://purl.obolibrary.org/obo/CLO_0052005	denotes	Skov-3
T195	6639-6645	http://purl.obolibrary.org/obo/CLO_0052006	denotes	Skov-3
T196	6639-6645	http://purl.obolibrary.org/obo/CLO_0052007	denotes	Skov-3
T197	6736-6740	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T198	6741-6750	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membranes
T199	6754-6755	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T200	7023-7024	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T201	7062-7068	http://purl.obolibrary.org/obo/UBERON_0000310	denotes	breast
T202	7289-7294	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T203	7334-7335	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T204	7368-7378	http://purl.obolibrary.org/obo/CLO_0000031	denotes	cell lines
T205	7529-7530	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T206	7536-7539	http://purl.obolibrary.org/obo/UBERON_0001013	denotes	fat
T207	7803-7805	http://purl.obolibrary.org/obo/CLO_0052676	denotes	FC
T208	7907-7915	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity
T209	7986-7997	http://purl.obolibrary.org/obo/CLO_0051862	denotes	HepG2 cells
T210	8009-8012	http://purl.obolibrary.org/obo/CLO_0054057	denotes	181
T211	8094-8099	http://purl.obolibrary.org/obo/UBERON_0002107	denotes	liver
T212	8094-8099	http://www.ebi.ac.uk/efo/EFO_0000887	denotes	liver
T213	8154-8156	http://purl.obolibrary.org/obo/CLO_0001627	denotes	AA
T214	8202-8203	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T215	8857-8862	http://purl.obolibrary.org/obo/CLO_0001571	denotes	A2780
T216	8857-8862	http://purl.obolibrary.org/obo/CLO_0051994	denotes	A2780
T217	8864-8869	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T218	8894-8897	http://purl.obolibrary.org/obo/CLO_0001230	denotes	293
T219	8894-8897	http://purl.obolibrary.org/obo/CLO_0037237	denotes	293
T220	8894-8897	http://purl.obolibrary.org/obo/CLO_0050903	denotes	293
T221	8894-8897	http://purl.obolibrary.org/obo/CLO_0054249	denotes	293
T222	8894-8897	http://purl.obolibrary.org/obo/CLO_0054250	denotes	293
T223	8894-8897	http://purl.obolibrary.org/obo/CLO_0054251	denotes	293
T224	8894-8897	http://purl.obolibrary.org/obo/CLO_0054252	denotes	293
T225	8899-8904	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T226	8905-8921	http://www.ebi.ac.uk/efo/EFO_0000927	denotes	embryonic kidney
T227	8923-8928	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T228	8962-8972	http://purl.obolibrary.org/obo/CLO_0000031	denotes	cell lines
T229	9008-9013	http://purl.obolibrary.org/obo/CLO_0001571	denotes	A2780
T230	9008-9013	http://purl.obolibrary.org/obo/CLO_0051994	denotes	A2780
T231	9015-9020	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T232	9759-9762	http://purl.obolibrary.org/obo/UBERON_0001007	denotes	gut
T233	9759-9762	http://purl.obolibrary.org/obo/UBERON_0001555	denotes	gut
T234	9759-9762	http://www.ebi.ac.uk/efo/EFO_0000834	denotes	gut
T235	10195-10200	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T236	10195-10200	http://www.ebi.ac.uk/efo/EFO_0000302	denotes	brain
T237	10313-10321	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membrane
T238	10339-10344	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T239	10559-10560	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T240	11133-11138	http://purl.obolibrary.org/obo/NCIT_C14239	denotes	nu/nu
T241	11265-11268	http://purl.obolibrary.org/obo/CLO_0051582	denotes	has
T242	11269-11270	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T243	11315-11316	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T244	11344-11349	http://purl.obolibrary.org/obo/UBERON_0000178	denotes	blood
T245	11344-11349	http://www.ebi.ac.uk/efo/EFO_0000296	denotes	blood
T246	11391-11393	http://purl.obolibrary.org/obo/CLO_0050510	denotes	18
T247	11549-11557	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity
T248	11667-11673	http://purl.obolibrary.org/obo/UBERON_0002107	denotes	livers
T249	11667-11673	http://www.ebi.ac.uk/efo/EFO_0000887	denotes	livers
T250	11748-11749	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T251	11826-11834	http://purl.obolibrary.org/obo/UBERON_0000158	denotes	membrane
T252	11873-11876	http://purl.obolibrary.org/obo/UBERON_0001007	denotes	gut
T253	11873-11876	http://purl.obolibrary.org/obo/UBERON_0001555	denotes	gut
T254	11873-11876	http://www.ebi.ac.uk/efo/EFO_0000834	denotes	gut
T255	12213-12214	http://purl.obolibrary.org/obo/CLO_0001020	denotes	ɑ
T256	12978-12981	http://purl.obolibrary.org/obo/PR_000002062	denotes	FMS
T257	12992-12996	http://purl.obolibrary.org/obo/PR_000002001	denotes	FLT3
T258	13063-13065	http://purl.obolibrary.org/obo/CLO_0007874	denotes	MS
T259	13471-13473	http://purl.obolibrary.org/obo/CLO_0007874	denotes	MS
T260	13560-13563	http://purl.obolibrary.org/obo/CLO_0002697	denotes	Dan
T261	14040-14048	http://purl.obolibrary.org/obo/CLO_0007225	denotes	labeling
T262	14287-14288	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T263	15184-15185	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T264	15619-15620	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T265	15829-15833	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T266	15873-15878	http://purl.obolibrary.org/obo/CLO_0009985	denotes	focus
T267	15891-15895	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T268	15912-15920	http://purl.obolibrary.org/obo/CLO_0007225	denotes	labeling
T269	16437-16442	http://purl.obolibrary.org/obo/NCBITaxon_9606	denotes	human
T270	16502-16503	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T271	16525-16526	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T272	16552-16553	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a
T273	16615-16616	http://purl.obolibrary.org/obo/CLO_0001020	denotes	a

LitCovid-PD-CHEBI

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T70443	1260-1264	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T78116	1557-1570	Chemical	denotes	ethyl acetate	http://purl.obolibrary.org/obo/CHEBI_27750
T92757	1557-1562	Chemical	denotes	ethyl	http://purl.obolibrary.org/obo/CHEBI_37807\|http://purl.obolibrary.org/obo/CHEBI_62801
T95349	1563-1570	Chemical	denotes	acetate	http://purl.obolibrary.org/obo/CHEBI_30089\|http://purl.obolibrary.org/obo/CHEBI_47622
T98922	1670-1672	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T5346	1938-1940	Chemical	denotes	RF	http://purl.obolibrary.org/obo/CHEBI_73818
T71763	2286-2288	Chemical	denotes	T2	http://purl.obolibrary.org/obo/CHEBI_29298\|http://purl.obolibrary.org/obo/CHEBI_75710
T86713	2345-2347	Chemical	denotes	RF	http://purl.obolibrary.org/obo/CHEBI_73818
T28891	2832-2834	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T54942	3112-3116	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T28372	3252-3258	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T172	3297-3304	Chemical	denotes	ligands	http://purl.obolibrary.org/obo/CHEBI_52214
T27613	3465-3474	Chemical	denotes	molecules	http://purl.obolibrary.org/obo/CHEBI_25367
T74596	3486-3494	Chemical	denotes	solution	http://purl.obolibrary.org/obo/CHEBI_75958
T2914	3698-3707	Chemical	denotes	molecules	http://purl.obolibrary.org/obo/CHEBI_25367
T11478	3836-3838	Chemical	denotes	SE	http://purl.obolibrary.org/obo/CHEBI_74813
T42044	4442-4446	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T33151	4591-4594	Chemical	denotes	MDD	http://purl.obolibrary.org/obo/CHEBI_566274
T64333	4627-4629	Chemical	denotes	CS	http://purl.obolibrary.org/obo/CHEBI_73462
T41133	4774-4776	Chemical	denotes	La	http://purl.obolibrary.org/obo/CHEBI_33336
T62326	5033-5038	Chemical	denotes	drugs	http://purl.obolibrary.org/obo/CHEBI_23888
T8592	5116-5125	Chemical	denotes	Isoniazid	http://purl.obolibrary.org/obo/CHEBI_6030
T59430	5288-5290	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T55975	5302-5304	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T38037	5329-5337	Chemical	denotes	Naproxen	http://purl.obolibrary.org/obo/CHEBI_7476
T60702	5339-5347	Chemical	denotes	Naproxen	http://purl.obolibrary.org/obo/CHEBI_7476
T99092	5384-5391	Chemical	denotes	choline	http://purl.obolibrary.org/obo/CHEBI_15354
T26968	5431-5441	Chemical	denotes	tryptophan	http://purl.obolibrary.org/obo/CHEBI_16828\|http://purl.obolibrary.org/obo/CHEBI_27897\|http://purl.obolibrary.org/obo/CHEBI_57719\|http://purl.obolibrary.org/obo/CHEBI_57912
T46340	5467-5469	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T90687	5492-5501	Chemical	denotes	Cisplatin	http://purl.obolibrary.org/obo/CHEBI_27899
T79027	5503-5505	Chemical	denotes	CP	http://purl.obolibrary.org/obo/CHEBI_3380\|http://purl.obolibrary.org/obo/CHEBI_73461\|http://purl.obolibrary.org/obo/CHEBI_27899
T26576	5537-5544	Chemical	denotes	alanine	http://purl.obolibrary.org/obo/CHEBI_16449
T69453	5546-5553	Chemical	denotes	betaine	http://purl.obolibrary.org/obo/CHEBI_17750
T64392	5555-5562	Chemical	denotes	glucose	http://purl.obolibrary.org/obo/CHEBI_17234\|http://purl.obolibrary.org/obo/CHEBI_4167
T27569	5564-5573	Chemical	denotes	glutamine	http://purl.obolibrary.org/obo/CHEBI_28300
T65786	5575-5582	Chemical	denotes	lactate	http://purl.obolibrary.org/obo/CHEBI_24996
T52241	5588-5595	Chemical	denotes	leucine	http://purl.obolibrary.org/obo/CHEBI_25017
T65782	5616-5623	Chemical	denotes	alanine	http://purl.obolibrary.org/obo/CHEBI_16449
T37509	5625-5632	Chemical	denotes	acetate	http://purl.obolibrary.org/obo/CHEBI_30089\|http://purl.obolibrary.org/obo/CHEBI_47622
T18053	5634-5641	Chemical	denotes	citrate	http://purl.obolibrary.org/obo/CHEBI_133748\|http://purl.obolibrary.org/obo/CHEBI_16947\|http://purl.obolibrary.org/obo/CHEBI_50744
T69706	5643-5650	Chemical	denotes	glucose	http://purl.obolibrary.org/obo/CHEBI_17234\|http://purl.obolibrary.org/obo/CHEBI_4167
T1785	5652-5659	Chemical	denotes	glycine	http://purl.obolibrary.org/obo/CHEBI_15428\|http://purl.obolibrary.org/obo/CHEBI_29947\|http://purl.obolibrary.org/obo/CHEBI_57305
T99520	5661-5677	Chemical	denotes	guanidinoacetate	http://purl.obolibrary.org/obo/CHEBI_131444\|http://purl.obolibrary.org/obo/CHEBI_57742
T94637	5679-5688	Chemical	denotes	hippurate	http://purl.obolibrary.org/obo/CHEBI_132966\|http://purl.obolibrary.org/obo/CHEBI_606565
T75683	5694-5701	Chemical	denotes	lactate	http://purl.obolibrary.org/obo/CHEBI_24996
T2578	5703-5714	Chemical	denotes	metabolites	http://purl.obolibrary.org/obo/CHEBI_25212
T66433	5750-5759	Chemical	denotes	cisplatin	http://purl.obolibrary.org/obo/CHEBI_27899
T49360	5777-5779	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T61524	5898-5908	Chemical	denotes	amino acid	http://purl.obolibrary.org/obo/CHEBI_33709
T86436	5898-5903	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T35392	5904-5908	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T75948	5974-5976	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T80509	6015-6025	Chemical	denotes	Ampicillin	http://purl.obolibrary.org/obo/CHEBI_28971
T27190	6047-6058	Chemical	denotes	antibiotics	http://purl.obolibrary.org/obo/CHEBI_33281
T26612	6129-6142	Chemical	denotes	nucleic acids	http://purl.obolibrary.org/obo/CHEBI_33696
T19466	6137-6142	Chemical	denotes	acids	http://purl.obolibrary.org/obo/CHEBI_37527
T46232	6156-6158	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T43041	6163-6165	Chemical	denotes	CP	http://purl.obolibrary.org/obo/CHEBI_3380\|http://purl.obolibrary.org/obo/CHEBI_73461\|http://purl.obolibrary.org/obo/CHEBI_27899
T17236	6172-6178	Chemical	denotes	Emodin	http://purl.obolibrary.org/obo/CHEBI_42223
T20609	6180-6186	Chemical	denotes	Emodin	http://purl.obolibrary.org/obo/CHEBI_42223
T95091	6251-6262	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T54970	6258-6262	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T38179	6281-6292	Chemical	denotes	glutathione	http://purl.obolibrary.org/obo/CHEBI_16856\|http://purl.obolibrary.org/obo/CHEBI_57925
T45525	6341-6343	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T43887	6355-6357	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T39123	6440-6451	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T21494	6447-6451	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T8911	6492-6501	Chemical	denotes	glutamate	http://purl.obolibrary.org/obo/CHEBI_14321\|http://purl.obolibrary.org/obo/CHEBI_29987
T61293	6503-6512	Chemical	denotes	glutamine	http://purl.obolibrary.org/obo/CHEBI_28300
T32686	6554-6556	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T64355	6568-6570	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T7971	6695-6706	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T48239	6702-6706	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T66521	6796-6805	Chemical	denotes	cisplatin	http://purl.obolibrary.org/obo/CHEBI_27899
T82218	6846-6853	Chemical	denotes	lactate	http://purl.obolibrary.org/obo/CHEBI_24996
T68362	6870-6872	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T57321	6884-6886	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T31260	6933-6944	Chemical	denotes	carboplatin	http://purl.obolibrary.org/obo/CHEBI_31355
T15844	6946-6948	Chemical	denotes	GC	http://purl.obolibrary.org/obo/CHEBI_73890
T32244	6985-6992	Chemical	denotes	formate	http://purl.obolibrary.org/obo/CHEBI_15740\|http://purl.obolibrary.org/obo/CHEBI_52343
T260	6997-7004	Chemical	denotes	acetate	http://purl.obolibrary.org/obo/CHEBI_30089\|http://purl.obolibrary.org/obo/CHEBI_47622
T49613	7046-7049	Chemical	denotes	MBC	http://purl.obolibrary.org/obo/CHEBI_3392
T64708	7099-7101	Chemical	denotes	GC	http://purl.obolibrary.org/obo/CHEBI_73890
T69324	7117-7119	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T79926	7138-7140	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T18850	7148-7150	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T12619	7186-7197	Chemical	denotes	Doxorubicin	http://purl.obolibrary.org/obo/CHEBI_28748
T50537	7199-7202	Chemical	denotes	DOX	http://purl.obolibrary.org/obo/CHEBI_28748
T30358	7204-7215	Chemical	denotes	dexrazoxane	http://purl.obolibrary.org/obo/CHEBI_50223
T72527	7217-7220	Chemical	denotes	DEX	http://purl.obolibrary.org/obo/CHEBI_50223
T18594	7223-7226	Chemical	denotes	DOX	http://purl.obolibrary.org/obo/CHEBI_28748
T9192	7237-7240	Chemical	denotes	ATP	http://purl.obolibrary.org/obo/CHEBI_15422\|http://purl.obolibrary.org/obo/CHEBI_30616
T69679	7296-7299	Chemical	denotes	DEX	http://purl.obolibrary.org/obo/CHEBI_50223
T52309	7381-7383	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T9849	7405-7413	Chemical	denotes	Curcumin	http://purl.obolibrary.org/obo/CHEBI_3962
T87092	7415-7423	Chemical	denotes	Curcumin	http://purl.obolibrary.org/obo/CHEBI_3962
T94712	7430-7448	Chemical	denotes	antihyperlipidemic	http://purl.obolibrary.org/obo/CHEBI_35679
T82664	7586-7597	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T62559	7593-7597	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T73970	7671-7684	Chemical	denotes	ketone bodies	http://purl.obolibrary.org/obo/CHEBI_73693
T65208	7671-7677	Chemical	denotes	ketone	http://purl.obolibrary.org/obo/CHEBI_17087
T51013	7689-7700	Chemical	denotes	cholesterol	http://purl.obolibrary.org/obo/CHEBI_16113
T7747	7706-7713	Chemical	denotes	choline	http://purl.obolibrary.org/obo/CHEBI_15354
T25997	7718-7728	Chemical	denotes	fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366
T55617	7724-7728	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T60198	7742-7744	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T70494	7762-7764	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T59989	7879-7882	Chemical	denotes	DNA	http://purl.obolibrary.org/obo/CHEBI_16991
T38162	7923-7934	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T83688	7930-7934	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T64796	8000-8002	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T93131	8014-8022	Chemical	denotes	Melamine	http://purl.obolibrary.org/obo/CHEBI_27915
T73579	8024-8032	Chemical	denotes	Melamine	http://purl.obolibrary.org/obo/CHEBI_27915
T32152	8056-8063	Chemical	denotes	glucose	http://purl.obolibrary.org/obo/CHEBI_17234\|http://purl.obolibrary.org/obo/CHEBI_4167
T55214	8065-8073	Chemical	denotes	nitrogen	http://purl.obolibrary.org/obo/CHEBI_25555
T61061	8079-8086	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T15172	8116-8118	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T7652	8135-8152	Chemical	denotes	Aristolochic acid	http://purl.obolibrary.org/obo/CHEBI_2825
T38023	8148-8152	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T26318	8154-8156	Chemical	denotes	AA	http://purl.obolibrary.org/obo/CHEBI_15843\|http://purl.obolibrary.org/obo/CHEBI_72816\|http://purl.obolibrary.org/obo/CHEBI_2825
T82804	8159-8176	Chemical	denotes	Aristolochic acid	http://purl.obolibrary.org/obo/CHEBI_2825
T18392	8172-8176	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T73694	8254-8256	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T52066	8359-8368	Chemical	denotes	rituximab	http://purl.obolibrary.org/obo/CHEBI_64357
T80883	8388-8399	Chemical	denotes	metabolites	http://purl.obolibrary.org/obo/CHEBI_25212
T84447	8454-8463	Chemical	denotes	succinate	http://purl.obolibrary.org/obo/CHEBI_26806\|http://purl.obolibrary.org/obo/CHEBI_30031
T47403	8465-8472	Chemical	denotes	taurine	http://purl.obolibrary.org/obo/CHEBI_15891\|http://purl.obolibrary.org/obo/CHEBI_507393
T99870	8474-8481	Chemical	denotes	lactate	http://purl.obolibrary.org/obo/CHEBI_24996
T33646	8483-8491	Chemical	denotes	pyruvate	http://purl.obolibrary.org/obo/CHEBI_15361
T83140	8496-8505	Chemical	denotes	aspartate	http://purl.obolibrary.org/obo/CHEBI_132943\|http://purl.obolibrary.org/obo/CHEBI_29995\|http://purl.obolibrary.org/obo/CHEBI_72314
T96044	8508-8510	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T57526	8522-8535	Chemical	denotes	Levetiracetam	http://purl.obolibrary.org/obo/CHEBI_6437
T45818	8550-8560	Chemical	denotes	Topiramate	http://purl.obolibrary.org/obo/CHEBI_63631
T99436	8585-8595	Chemical	denotes	metabolite	http://purl.obolibrary.org/obo/CHEBI_25212
T46025	8641-8654	Chemical	denotes	levetiracetam	http://purl.obolibrary.org/obo/CHEBI_6437
T9419	8656-8667	Chemical	denotes	lamotrigine	http://purl.obolibrary.org/obo/CHEBI_6367
T80482	8672-8682	Chemical	denotes	topiramate	http://purl.obolibrary.org/obo/CHEBI_63631
T16503	8747-8749	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T78916	8785-8794	Chemical	denotes	Ruthenium	http://purl.obolibrary.org/obo/CHEBI_30682
T9566	8837-8842	Chemical	denotes	lipid	http://purl.obolibrary.org/obo/CHEBI_18059
T45246	8944-8947	Chemical	denotes	GSH	http://purl.obolibrary.org/obo/CHEBI_16856
T83737	8988-8997	Chemical	denotes	cisplatin	http://purl.obolibrary.org/obo/CHEBI_27899
T91790	9022-9027	Chemical	denotes	lipid	http://purl.obolibrary.org/obo/CHEBI_18059
T49326	9115-9117	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T23753	9124-9126	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T2183	9136-9138	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T70915	9139-9141	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T35672	9148-9150	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T28905	9259-9270	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T11681	9266-9270	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T66251	9311-9316	Chemical	denotes	lipid	http://purl.obolibrary.org/obo/CHEBI_18059
T84782	9358-9360	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T55290	9395-9407	Chemical	denotes	thiadiazoles	http://purl.obolibrary.org/obo/CHEBI_38099
T32356	9432-9440	Chemical	denotes	glycerol	http://purl.obolibrary.org/obo/CHEBI_17754
T17522	9462-9469	Chemical	denotes	betaine	http://purl.obolibrary.org/obo/CHEBI_17750
T17397	9537-9540	Chemical	denotes	DMH	http://purl.obolibrary.org/obo/CHEBI_73755
T12199	9587-9589	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T42352	9798-9800	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T56462	9812-9814	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T7825	9934-9945	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T12125	9941-9945	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T74139	9956-9966	Chemical	denotes	amino acid	http://purl.obolibrary.org/obo/CHEBI_33709
T80871	9956-9961	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T63266	9962-9966	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T27761	10087-10089	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T88796	10256-10260	Chemical	denotes	GABA	http://purl.obolibrary.org/obo/CHEBI_16865
T41668	10265-10272	Chemical	denotes	glycine	http://purl.obolibrary.org/obo/CHEBI_15428\|http://purl.obolibrary.org/obo/CHEBI_29947\|http://purl.obolibrary.org/obo/CHEBI_57305
T66104	10399-10401	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T39070	10419-10421	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T14635	10430-10432	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T94784	10456-10468	Chemical	denotes	Pyrazinamide	http://purl.obolibrary.org/obo/CHEBI_45285
T61592	10470-10479	Chemical	denotes	Isoniazid	http://purl.obolibrary.org/obo/CHEBI_6030
T72175	10481-10497	Chemical	denotes	Sulfamethoxazole	http://purl.obolibrary.org/obo/CHEBI_9332
T8081	10561-10565	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T19963	10610-10615	Chemical	denotes	drugs	http://purl.obolibrary.org/obo/CHEBI_23888
T22591	10676-10678	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T74183	10696-10698	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T99926	10711-10718	Chemical	denotes	Genipin	http://purl.obolibrary.org/obo/CHEBI_5298
T94443	10720-10727	Chemical	denotes	Genipin	http://purl.obolibrary.org/obo/CHEBI_5298
T41770	10789-10800	Chemical	denotes	methylamine	http://purl.obolibrary.org/obo/CHEBI_16830\|http://purl.obolibrary.org/obo/CHEBI_59338
T77247	10805-10815	Chemical	denotes	amino acid	http://purl.obolibrary.org/obo/CHEBI_33709
T73179	10805-10810	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T30330	10811-10815	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T64289	10862-10864	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T84578	10881-10891	Chemical	denotes	Adriamycin	http://purl.obolibrary.org/obo/CHEBI_28748
T65801	10893-10896	Chemical	denotes	ADR	http://purl.obolibrary.org/obo/CHEBI_28748
T37265	10935-10955	Chemical	denotes	trimethylamine oxide	http://purl.obolibrary.org/obo/CHEBI_15724
T11530	10935-10949	Chemical	denotes	trimethylamine	http://purl.obolibrary.org/obo/CHEBI_18139\|http://purl.obolibrary.org/obo/CHEBI_58389
T52545	10950-10955	Chemical	denotes	oxide	http://purl.obolibrary.org/obo/CHEBI_25741\|http://purl.obolibrary.org/obo/CHEBI_29356
T67304	10957-10961	Chemical	denotes	TMAO	http://purl.obolibrary.org/obo/CHEBI_15724
T49996	10964-10971	Chemical	denotes	taurine	http://purl.obolibrary.org/obo/CHEBI_15891\|http://purl.obolibrary.org/obo/CHEBI_507393
T34716	10973-10987	Chemical	denotes	trimethylamine	http://purl.obolibrary.org/obo/CHEBI_18139\|http://purl.obolibrary.org/obo/CHEBI_58389
T38410	10989-10992	Chemical	denotes	TMA	http://purl.obolibrary.org/obo/CHEBI_166055\|http://purl.obolibrary.org/obo/CHEBI_18139\|http://purl.obolibrary.org/obo/CHEBI_53050\|http://purl.obolibrary.org/obo/CHEBI_60567\|http://purl.obolibrary.org/obo/CHEBI_60610
T8083	10995-11004	Chemical	denotes	hippurate	http://purl.obolibrary.org/obo/CHEBI_132966\|http://purl.obolibrary.org/obo/CHEBI_606565
T80118	11020-11027	Chemical	denotes	citrate	http://purl.obolibrary.org/obo/CHEBI_133748\|http://purl.obolibrary.org/obo/CHEBI_16947\|http://purl.obolibrary.org/obo/CHEBI_50744
T47001	11032-11046	Chemical	denotes	2-oxoglutarate	http://purl.obolibrary.org/obo/CHEBI_16810
T40491	11109-11112	Chemical	denotes	ADR	http://purl.obolibrary.org/obo/CHEBI_28748
T92145	11133-11135	Chemical	denotes	nu	http://purl.obolibrary.org/obo/CHEBI_36352
T69119	11136-11138	Chemical	denotes	nu	http://purl.obolibrary.org/obo/CHEBI_36352
T49757	11146-11148	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T39310	11394-11405	Chemical	denotes	metabolites	http://purl.obolibrary.org/obo/CHEBI_25212
T56491	11438-11440	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T88158	11469-11471	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T75358	11494-11506	Chemical	denotes	Erythromycin	http://purl.obolibrary.org/obo/CHEBI_42355
T83495	11508-11520	Chemical	denotes	Erythromycin	http://purl.obolibrary.org/obo/CHEBI_42355
T14819	11531-11542	Chemical	denotes	citric acid	http://purl.obolibrary.org/obo/CHEBI_30769
T40585	11538-11542	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T99316	11568-11578	Chemical	denotes	fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366
T45362	11574-11578	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T44367	11612-11622	Chemical	denotes	amino acid	http://purl.obolibrary.org/obo/CHEBI_33709
T57294	11612-11617	Chemical	denotes	amino	http://purl.obolibrary.org/obo/CHEBI_46882
T84184	11618-11622	Chemical	denotes	acid	http://purl.obolibrary.org/obo/CHEBI_37527
T23056	11691-11693	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T3864	11975-11977	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T44785	12032-12034	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T11949	12094-12102	Chemical	denotes	naringin	http://purl.obolibrary.org/obo/CHEBI_28819
T60351	12104-12111	Chemical	denotes	sucrose	http://purl.obolibrary.org/obo/CHEBI_17992
T63953	12119-12126	Chemical	denotes	glucose	http://purl.obolibrary.org/obo/CHEBI_17234\|http://purl.obolibrary.org/obo/CHEBI_4167
T17899	12188-12196	Chemical	denotes	naringin	http://purl.obolibrary.org/obo/CHEBI_28819
T2659	12198-12211	Chemical	denotes	neohesperidin	http://purl.obolibrary.org/obo/CHEBI_59016
T28294	12222-12229	Chemical	denotes	glucose	http://purl.obolibrary.org/obo/CHEBI_17234\|http://purl.obolibrary.org/obo/CHEBI_4167
T51995	12231-12238	Chemical	denotes	sucrose	http://purl.obolibrary.org/obo/CHEBI_17992
T59274	12240-12248	Chemical	denotes	limonene	http://purl.obolibrary.org/obo/CHEBI_15384
T38831	12250-12259	Chemical	denotes	narirutin	http://purl.obolibrary.org/obo/CHEBI_28705
T12346	12265-12275	Chemical	denotes	synephrine	http://purl.obolibrary.org/obo/CHEBI_29081\|http://purl.obolibrary.org/obo/CHEBI_58606
T40181	12279-12281	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T95431	12443-12448	Chemical	denotes	drugs	http://purl.obolibrary.org/obo/CHEBI_23888
T61683	12943-12950	Chemical	denotes	PLX3397	http://purl.obolibrary.org/obo/CHEBI_145373
T54879	13063-13065	Chemical	denotes	MS	http://purl.obolibrary.org/obo/CHEBI_73613
T36558	13319-13321	Chemical	denotes	II	http://purl.obolibrary.org/obo/CHEBI_74067
T92376	13410-13416	Chemical	denotes	AT7519	http://purl.obolibrary.org/obo/CHEBI_91326
T35664	13471-13473	Chemical	denotes	MS	http://purl.obolibrary.org/obo/CHEBI_73613
T49784	13960-13966	Chemical	denotes	nuclei	http://purl.obolibrary.org/obo/CHEBI_33252
T78546	13978-13980	Chemical	denotes	1H	http://purl.obolibrary.org/obo/CHEBI_49637
T55022	14111-14120	Chemical	denotes	molecules	http://purl.obolibrary.org/obo/CHEBI_25367
T52980	14168-14174	Chemical	denotes	nuclei	http://purl.obolibrary.org/obo/CHEBI_33252
T56383	14667-14670	Chemical	denotes	MDD	http://purl.obolibrary.org/obo/CHEBI_566274
T21913	14884-14886	Chemical	denotes	CS	http://purl.obolibrary.org/obo/CHEBI_73462
T84653	15260-15267	Chemical	denotes	ligands	http://purl.obolibrary.org/obo/CHEBI_52214
T60113	15440-15446	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T79064	15581-15587	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T3417	15591-15598	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T86859	15694-15700	Chemical	denotes	ligand	http://purl.obolibrary.org/obo/CHEBI_52214
T53221	15726-15733	Chemical	denotes	ligands	http://purl.obolibrary.org/obo/CHEBI_52214
T59728	16022-16029	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T89255	16030-16034	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T90308	16083-16087	Chemical	denotes	drug	http://purl.obolibrary.org/obo/CHEBI_23888
T26569	16098-16105	Chemical	denotes	Protein	http://purl.obolibrary.org/obo/CHEBI_16541
T60248	16183-16191	Chemical	denotes	proteins	http://purl.obolibrary.org/obo/CHEBI_36080
T69582	16215-16219	Chemical	denotes	ions	http://purl.obolibrary.org/obo/CHEBI_24870
T8333	16302-16307	Chemical	denotes	atoms	http://purl.obolibrary.org/obo/CHEBI_33250
T65120	16443-16445	Chemical	denotes	La	http://purl.obolibrary.org/obo/CHEBI_33336
T78430	16446-16453	Chemical	denotes	antigen	http://purl.obolibrary.org/obo/CHEBI_59132
T1428	16454-16461	Chemical	denotes	protein	http://purl.obolibrary.org/obo/CHEBI_36080
T14147	16504-16521	Chemical	denotes	chemical compound	http://purl.obolibrary.org/obo/CHEBI_37577
T89705	16796-16803	Chemical	denotes	ligands	http://purl.obolibrary.org/obo/CHEBI_52214

LitCovid-PubTator

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id	tao:has_standard_notation
1920	1557-1570	Chemical	denotes	ethyl acetate	MESH:C007650
1921	1670-1672	Chemical	denotes	1H
1923	1805-1806	Gene	denotes	τ	Gene:4137
1925	2173-2190	Disease	denotes	longitudinal axis	MESH:C566610
1927	2638-2642	Gene	denotes	spin	Gene:10927
1929	2747-2751	Gene	denotes	High	Gene:104137
1932	2832-2838	Chemical	denotes	1H-15N
1933	2916-2933	Chemical	denotes	2-phenylimidazole	MESH:C059194
1935	3502-3506	Gene	denotes	high	Gene:104137
1937	3825-3829	Gene	denotes	Spin	Gene:10927
1940	4869-4872	Species	denotes	SAR	Tax:2698737
1941	4591-4594	Disease	denotes	MDD	MESH:D003865
2164	7652-7656	Gene	denotes	BCAA	Gene:51742
2165	6408-6412	Gene	denotes	pill	Gene:8319132
2166	7531-7535	Gene	denotes	high	Gene:104137
2167	5841-5845	Gene	denotes	high	Gene:104137
2168	5266-5285	Species	denotes	Sprague Dawley rats	Tax:10116
2169	5445-5464	Species	denotes	Sprague Dawley rats	Tax:10116
2170	5952-5971	Species	denotes	Sprague-Dawley rats	Tax:10116
2171	6146-6153	Species	denotes	E. coli	Tax:562
2172	6540-6551	Species	denotes	Wistar rats	Tax:10116
2173	7077-7085	Species	denotes	patients	Tax:9606
2174	7472-7476	Species	denotes	mice	Tax:10090
2175	8110-8113	Species	denotes	rat	Tax:10116
2176	8240-8251	Species	denotes	Wistar rats	Tax:10116
2177	8310-8318	Species	denotes	patients	Tax:9606
2178	8619-8627	Species	denotes	patients	Tax:9606
2179	8899-8904	Species	denotes	human	Tax:9606
2180	9169-9186	Species	denotes	Centella asiatica	Tax:48106
2181	9336-9355	Species	denotes	Sprague–Dawley rats	Tax:10116
2182	9573-9584	Species	denotes	Wistar rats	Tax:10116
2183	9787-9795	Species	denotes	patients	Tax:9606
2184	10065-10084	Species	denotes	Sprague-Dawley rats	Tax:10116
2185	10363-10367	Species	denotes	mice	Tax:10090
2186	10665-10673	Species	denotes	patients	Tax:9606
2187	10840-10859	Species	denotes	Sprague Dawley rats	Tax:10116
2188	11139-11143	Species	denotes	mice	Tax:10090
2189	11677-11688	Species	denotes	Wistar rats	Tax:10116
2190	11891-11902	Species	denotes	Wistar rats	Tax:10116
2191	8154-8156	Gene	denotes	AA	Gene:351
2192	5116-5125	Chemical	denotes	Isoniazid	MESH:D007538
2193	5288-5290	Chemical	denotes	1H
2194	5302-5304	Chemical	denotes	1H
2195	5313-5316	Chemical	denotes	13C	MESH:C000615229
2196	5329-5337	Chemical	denotes	Naproxen	MESH:D009288
2197	5339-5347	Chemical	denotes	Naproxen	MESH:D009288
2198	5384-5391	Chemical	denotes	choline	MESH:D002794
2199	5431-5441	Chemical	denotes	tryptophan	MESH:D014364
2200	5467-5469	Chemical	denotes	1H
2201	5492-5501	Chemical	denotes	Cisplatin	MESH:D002945
2202	5537-5544	Chemical	denotes	alanine	MESH:D000409
2203	5546-5553	Chemical	denotes	betaine	MESH:D001622
2204	5555-5562	Chemical	denotes	glucose	MESH:D005947
2205	5564-5573	Chemical	denotes	glutamine	MESH:D005973
2206	5575-5582	Chemical	denotes	lactate	MESH:D019344
2207	5588-5595	Chemical	denotes	leucine	MESH:D007930
2208	5616-5623	Chemical	denotes	alanine	MESH:D000409
2209	5625-5632	Chemical	denotes	acetate	MESH:D000085
2210	5634-5641	Chemical	denotes	citrate	MESH:D019343
2211	5643-5650	Chemical	denotes	glucose	MESH:D005947
2212	5652-5659	Chemical	denotes	glycine	MESH:D005998
2213	5661-5677	Chemical	denotes	guanidinoacetate	MESH:C004946
2214	5679-5688	Chemical	denotes	hippurate	MESH:C030514
2215	5694-5701	Chemical	denotes	lactate	MESH:D019344
2216	5750-5759	Chemical	denotes	cisplatin	MESH:D002945
2217	5777-5779	Chemical	denotes	1H
2218	5974-5976	Chemical	denotes	1H
2219	5988-5991	Chemical	denotes	13C	MESH:C000615229
2220	5999-6002	Chemical	denotes	13C	MESH:C000615229
2221	6015-6025	Chemical	denotes	Ampicillin	MESH:D000667
2222	6156-6158	Chemical	denotes	1H
2223	6159-6162	Chemical	denotes	31P
2224	6251-6262	Chemical	denotes	citric acid	MESH:D019343
2225	6281-6292	Chemical	denotes	glutathione	MESH:D005978
2226	6341-6343	Chemical	denotes	1H
2227	6365-6368	Chemical	denotes	13C	MESH:C000615229
2228	6440-6451	Chemical	denotes	citric acid	MESH:D019343
2229	6492-6501	Chemical	denotes	glutamate	MESH:D018698
2230	6503-6512	Chemical	denotes	glutamine	MESH:D005973
2231	6517-6522	Chemical	denotes	BCAAs	MESH:D000597
2232	6554-6556	Chemical	denotes	1H
2233	6578-6581	Chemical	denotes	13C	MESH:C000615229
2234	6695-6706	Chemical	denotes	citric acid	MESH:D019343
2235	6796-6805	Chemical	denotes	cisplatin	MESH:D002945
2236	6827-6833	Chemical	denotes	Ptac2S
2237	6870-6872	Chemical	denotes	1H
2238	6894-6897	Chemical	denotes	13C	MESH:C000615229
2239	6905-6913	Chemical	denotes	13C-HMBC
2240	6921-6932	Chemical	denotes	Gemcitabine	MESH:C056507
2241	6933-6944	Chemical	denotes	carboplatin	MESH:D016190
2242	6946-6948	Chemical	denotes	GC
2243	6985-6992	Chemical	denotes	formate	MESH:C030544
2244	6997-7004	Chemical	denotes	acetate	MESH:D000085
2245	7117-7119	Chemical	denotes	1H
2246	7148-7150	Chemical	denotes	1H
2247	7159-7162	Chemical	denotes	13C	MESH:C000615229
2248	7186-7197	Chemical	denotes	Doxorubicin	MESH:D004317
2249	7199-7202	Chemical	denotes	DOX	MESH:D004317
2250	7204-7215	Chemical	denotes	dexrazoxane	MESH:D064730
2251	7217-7220	Chemical	denotes	DEX	MESH:D064730
2252	7223-7226	Chemical	denotes	DOX	MESH:D004317
2253	7237-7240	Chemical	denotes	ATP	MESH:D000255
2254	7296-7299	Chemical	denotes	DEX	MESH:D064730
2255	7381-7383	Chemical	denotes	1H
2256	7405-7413	Chemical	denotes	Curcumin	MESH:D003474
2257	7415-7423	Chemical	denotes	Curcumin	MESH:D003474
2258	7586-7597	Chemical	denotes	citric acid	MESH:D019343
2259	7671-7677	Chemical	denotes	ketone	MESH:D007659
2260	7689-7700	Chemical	denotes	cholesterol	MESH:D002784
2261	7706-7713	Chemical	denotes	choline	MESH:D002794
2262	7718-7728	Chemical	denotes	fatty acid	MESH:D005227
2263	7742-7744	Chemical	denotes	1H
2264	7923-7934	Chemical	denotes	citric acid	MESH:D019343
2265	8000-8002	Chemical	denotes	1H
2266	8014-8032	Chemical	denotes	Melamine Melamine
2267	8056-8063	Chemical	denotes	glucose	MESH:D005947
2268	8065-8073	Chemical	denotes	nitrogen	MESH:D009584
2269	8116-8118	Chemical	denotes	1H
2270	8135-8152	Chemical	denotes	Aristolochic acid	MESH:C000228
2271	8159-8176	Chemical	denotes	Aristolochic acid	MESH:C000228
2272	8254-8256	Chemical	denotes	1H
2273	8267-8276	Chemical	denotes	Rituximab	MESH:D000069283
2274	8359-8368	Chemical	denotes	rituximab	MESH:D000069283
2275	8454-8463	Chemical	denotes	succinate	MESH:D019802
2276	8465-8472	Chemical	denotes	taurine	MESH:D013654
2277	8474-8481	Chemical	denotes	lactate	MESH:D019344
2278	8483-8491	Chemical	denotes	pyruvate	MESH:D019289
2279	8496-8505	Chemical	denotes	aspartate	MESH:D001224
2280	8508-8510	Chemical	denotes	1H
2281	8522-8535	Chemical	denotes	Levetiracetam	MESH:D000077287
2282	8537-8548	Chemical	denotes	Lamotrigine	MESH:D000077213
2283	8550-8560	Chemical	denotes	Topiramate	MESH:D000077236
2284	8641-8654	Chemical	denotes	levetiracetam	MESH:D000077287
2285	8656-8667	Chemical	denotes	lamotrigine	MESH:D000077213
2286	8672-8682	Chemical	denotes	topiramate	MESH:D000077236
2287	8747-8749	Chemical	denotes	1H
2288	8785-8794	Chemical	denotes	Ruthenium	MESH:D012428
2289	8837-8842	Chemical	denotes	lipid	MESH:D008055
2290	8944-8947	Chemical	denotes	GSH	MESH:D005978
2291	8988-8997	Chemical	denotes	cisplatin	MESH:D002945
2292	9022-9027	Chemical	denotes	lipid	MESH:D008055
2293	9112-9117	Chemical	denotes	1D-1H
2294	9124-9126	Chemical	denotes	1H
2295	9133-9135	Chemical	denotes	2D
2296	9136-9138	Chemical	denotes	1H
2297	9139-9150	Chemical	denotes	1H-TOCSY-1H
2298	9259-9270	Chemical	denotes	citric acid	MESH:D019343
2299	9358-9360	Chemical	denotes	1H
2300	9389-9407	Chemical	denotes	1,3,4-thiadiazoles	MESH:C058949
2301	9432-9440	Chemical	denotes	glycerol	MESH:D005990
2302	9462-9469	Chemical	denotes	betaine	MESH:D001622
2303	9513-9524	Chemical	denotes	myoinositol	MESH:D007294
2304	9537-9540	Chemical	denotes	DMH	MESH:D004111
2305	9587-9589	Chemical	denotes	1H
2306	9798-9800	Chemical	denotes	1H
2307	9822-9825	Chemical	denotes	13C	MESH:C000615229
2308	9934-9945	Chemical	denotes	citric acid	MESH:D019343
2309	10087-10089	Chemical	denotes	1H
2310	10256-10260	Chemical	denotes	GABA	MESH:D005680
2311	10265-10272	Chemical	denotes	glycine	MESH:D005998
2312	10399-10401	Chemical	denotes	1H
2313	10419-10429	Chemical	denotes	1H-gCOSY1H
2314	10430-10454	Chemical	denotes	1H-TOCSY [87] Acyclovir
2315	10456-10468	Chemical	denotes	Pyrazinamide	MESH:D011718
2316	10470-10479	Chemical	denotes	Isoniazid	MESH:D007538
2317	10481-10497	Chemical	denotes	Sulfamethoxazole	MESH:D013420
2318	10676-10678	Chemical	denotes	1H
2319	10789-10800	Chemical	denotes	methylamine	MESH:C027451
2320	10862-10864	Chemical	denotes	1H
2321	10881-10891	Chemical	denotes	Adriamycin	MESH:D004317
2322	10935-10955	Chemical	denotes	trimethylamine oxide	MESH:C005855
2323	10957-10961	Chemical	denotes	TMAO	MESH:C005855
2324	10964-10971	Chemical	denotes	taurine	MESH:D013654
2325	10973-10987	Chemical	denotes	trimethylamine	MESH:C023336
2326	10995-11004	Chemical	denotes	hippurate	MESH:C030514
2327	11006-11018	Chemical	denotes	trigonelline	MESH:C009560
2328	11020-11027	Chemical	denotes	citrate	MESH:D019343
2329	11032-11046	Chemical	denotes	2-oxoglutarate	MESH:D007656
2330	11146-11148	Chemical	denotes	1H
2331	11438-11440	Chemical	denotes	1H
2332	11479-11482	Chemical	denotes	13C	MESH:C000615229
2333	11494-11506	Chemical	denotes	Erythromycin	MESH:D004917
2334	11508-11520	Chemical	denotes	Erythromycin	MESH:D004917
2335	11531-11542	Chemical	denotes	citric acid	MESH:D019343
2336	11568-11578	Chemical	denotes	fatty acid	MESH:D005227
2337	11691-11693	Chemical	denotes	1H
2338	11975-11977	Chemical	denotes	1H
2339	12032-12034	Chemical	denotes	1H
2340	12094-12102	Chemical	denotes	naringin	MESH:C005274
2341	12104-12111	Chemical	denotes	sucrose	MESH:D013395
2342	12119-12126	Chemical	denotes	glucose	MESH:D005947
2343	12133-12136	Chemical	denotes	13C	MESH:C000615229
2344	12188-12196	Chemical	denotes	naringin	MESH:C005274
2345	12198-12211	Chemical	denotes	neohesperidin	MESH:C546526
2346	12222-12229	Chemical	denotes	glucose	MESH:D005947
2347	12231-12238	Chemical	denotes	sucrose	MESH:D013395
2348	12240-12248	Chemical	denotes	limonene	MESH:D000077222
2349	12250-12259	Chemical	denotes	narirutin	MESH:C500601
2350	12265-12275	Chemical	denotes	synephrine	MESH:D013578
2351	12279-12281	Chemical	denotes	1H
2352	5760-5774	Disease	denotes	nephrotoxicity	MESH:D007674
2353	6626-6632	Disease	denotes	cancer	MESH:D009369
2354	7062-7075	Disease	denotes	breast cancer	MESH:D001943
2355	7500-7517	Disease	denotes	metabolic defects	MESH:D008659
2356	8184-8197	Disease	denotes	renal lesions	MESH:D007674
2357	8324-8344	Disease	denotes	rheumatoid arthritis	MESH:D001172
2358	8736-8744	Disease	denotes	epilepsy	MESH:D004827
2359	8864-8884	Disease	denotes	human ovarian cancer	MESH:D010051
2360	8905-8921	Disease	denotes	embryonic kidney	MESH:D007674
2361	9209-9246	Disease	denotes	Centella asiatica promotes glycolysis	MESH:C564972
2362	9281-9327	Disease	denotes	decreases gluconeogenesis and lipid metabolism	MESH:D052439
2363	9549-9552	Disease	denotes	CRC	MESH:D015179
2364	9554-9571	Disease	denotes	colorectal cancer	MESH:D015179
2365	9777-9786	Disease	denotes	depressed	MESH:D000275
2366	10379-10396	Disease	denotes	hypobaric hypoxia	MESH:D000860
2367	10642-10664	Disease	denotes	tuberculous meningitis	MESH:D014390
2368	10831-10839	Disease	denotes	diabetic	MESH:D003920
2369	11064-11069	Disease	denotes	tumor	MESH:D009369
2370	11073-11095	Disease	denotes	gastric adenocarcinoma	MESH:D013274
2371	11597-11608	Disease	denotes	dysfunction	MESH:D009461
2372	11835-11843	Disease	denotes	toxicity	MESH:D064420
2373	6356-6364	CellLine	denotes	H-COSY1H	CVCL:Z499
2374	6569-6577	CellLine	denotes	H-COSY1H	CVCL:Z499
2375	6885-6893	CellLine	denotes	H-COSY1H	CVCL:Z499
2376	7139-7147	CellLine	denotes	H-COSY1H	CVCL:Z499
2377	7284-7288	CellLine	denotes	H9C2	CVCL:0286
2378	7363-7367	CellLine	denotes	H9C2	CVCL:0286
2379	7986-7991	CellLine	denotes	HepG2	CVCL:0027
2380	8857-8862	CellLine	denotes	A2780	CVCL:0134
2381	8890-8897	CellLine	denotes	HEK-293	CVCL:0045
2382	8977-8982	CellLine	denotes	A2780	CVCL:0134
2383	9008-9013	CellLine	denotes	A2780	CVCL:0134
2384	9813-9821	CellLine	denotes	H-COSY1H	CVCL:Z499
2385	11470-11478	CellLine	denotes	H-COSY1H	CVCL:Z499
2395	12631-12635	Gene	denotes	BRAF	Gene:673
2396	12776-12781	Gene	denotes	BCL-2	Gene:596
2397	12868-12872	Gene	denotes	CDK4	Gene:1019
2398	12992-12996	Gene	denotes	FLT3	Gene:2322
2399	13108-13113	Gene	denotes	BACE1	Gene:23621
2400	13436-13447	Gene	denotes	CDK 1, 2, 4	Gene:983
2401	13208-13213	Gene	denotes	HSP90	Gene:3320
2402	12654-12658	Gene	denotes	high	Gene:104137
2403	12636-12641	Mutation	denotes	V600E		rs113488022
2405	12466-12470	Chemical	denotes	FBDD
2407	13560-13563	Gene	denotes	Dan	Gene:4681
2421	14884-14886	Gene	denotes	CS	Gene:1431
2422	16697-16701	Gene	denotes	spin	Gene:10927
2423	14220-14224	Gene	denotes	spin	Gene:10927
2424	16561-16565	Gene	denotes	pill	Gene:8319132
2425	13776-13780	Gene	denotes	High	Gene:104137
2426	15395-15398	Species	denotes	SAR	Tax:2698737
2427	16437-16442	Species	denotes	human	Tax:9606
2428	13872-13874	Chemical	denotes	2D
2429	13893-13895	Chemical	denotes	2D
2430	13978-13980	Chemical	denotes	1H
2431	15225-15229	Chemical	denotes	FBDD
2432	16209-16214	Chemical	denotes	metal	MESH:D008670
2433	14667-14670	Disease	denotes	MDD	MESH:D003865

LitCovid-PD-GO-BP

Id	Subject	Object	Predicate	Lexical cue
T7	3670-3683	http://purl.obolibrary.org/obo/GO_0006412	denotes	translational
T8	4641-4650	http://purl.obolibrary.org/obo/GO_0023052	denotes	Signaling
T9	5179-5189	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T10	5215-5232	http://purl.obolibrary.org/obo/GO_0007268	denotes	neurotransmission
T11	5384-5402	http://purl.obolibrary.org/obo/GO_0019695	denotes	choline metabolism
T12	5392-5402	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T13	5417-5427	http://purl.obolibrary.org/obo/GO_0009056	denotes	catabolism
T14	5909-5919	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T15	6116-6125	http://purl.obolibrary.org/obo/GO_0009056	denotes	breakdown
T16	6202-6217	http://purl.obolibrary.org/obo/GO_0006955	denotes	immune response
T17	6239-6249	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T18	6251-6268	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T19	6281-6302	http://purl.obolibrary.org/obo/GO_0006750	denotes	glutathione synthesis
T20	6293-6302	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21	6440-6457	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T22	6695-6712	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T23	7586-7603	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T24	7605-7615	http://purl.obolibrary.org/obo/GO_0006096	denotes	glycolysis
T25	7620-7635	http://purl.obolibrary.org/obo/GO_0006094	denotes	gluconeogenesis
T26	7658-7667	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T27	7718-7739	http://purl.obolibrary.org/obo/GO_0006631	denotes	fatty acid metabolism
T28	7729-7739	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T29	7850-7859	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T30	7864-7875	http://purl.obolibrary.org/obo/GO_0032259	denotes	methylation
T31	7923-7940	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T32	7952-7962	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T33	8042-8052	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T34	8837-8853	http://purl.obolibrary.org/obo/GO_0006629	denotes	lipid metabolism
T35	8843-8853	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T36	9043-9056	http://purl.obolibrary.org/obo/GO_0070085	denotes	glycosylation
T37	9236-9246	http://purl.obolibrary.org/obo/GO_0006096	denotes	glycolysis
T38	9259-9276	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T39	9291-9306	http://purl.obolibrary.org/obo/GO_0006094	denotes	gluconeogenesis
T40	9311-9327	http://purl.obolibrary.org/obo/GO_0006629	denotes	lipid metabolism
T41	9317-9327	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T42	9432-9451	http://purl.obolibrary.org/obo/GO_0006071	denotes	glycerol metabolism
T43	9441-9451	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T44	9646-9656	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T45	9692-9702	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T46	9905-9915	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T47	9934-9951	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T48	9967-9977	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T49	10181-10191	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T50	10265-10282	http://purl.obolibrary.org/obo/GO_0016934	denotes	glycine receptors
T51	10265-10282	http://purl.obolibrary.org/obo/GO_0016933	denotes	glycine receptors
T52	10747-10757	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T53	10816-10827	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolisms
T54	11531-11548	http://purl.obolibrary.org/obo/GO_0006099	denotes	citric acid cycle
T55	11568-11588	http://purl.obolibrary.org/obo/GO_0019395	denotes	fatty acid oxidation
T56	11623-11633	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T57	11766-11776	http://purl.obolibrary.org/obo/GO_0008152	denotes	metabolism
T58	11783-11802	http://purl.obolibrary.org/obo/GO_0009060	denotes	aerobic respiration
T59	11791-11802	http://purl.obolibrary.org/obo/GO_0045333	denotes	respiration
T60	11791-11802	http://purl.obolibrary.org/obo/GO_0007585	denotes	respiration
T61	15775-15783	http://purl.obolibrary.org/obo/GO_0015297	denotes	exchange
T62	16424-16433	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis

LitCovid-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T21	5145-5161	Phenotype	denotes	oxidative stress	http://purl.obolibrary.org/obo/HP_0025464
T22	5932-5948	Phenotype	denotes	oxidative stress	http://purl.obolibrary.org/obo/HP_0025464
T23	6322-6338	Phenotype	denotes	oxidative stress	http://purl.obolibrary.org/obo/HP_0025464
T24	6626-6632	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T25	7062-7075	Phenotype	denotes	breast cancer	http://purl.obolibrary.org/obo/HP_0003002
T26	7264-7280	Phenotype	denotes	oxidative stress	http://purl.obolibrary.org/obo/HP_0025464
T27	8324-8344	Phenotype	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370
T28	8736-8744	Phenotype	denotes	epilepsy	http://purl.obolibrary.org/obo/HP_0001250
T29	8870-8884	Phenotype	denotes	ovarian cancer	http://purl.obolibrary.org/obo/HP_0100615
T30	9565-9571	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664
T31	10389-10396	Phenotype	denotes	hypoxia	http://purl.obolibrary.org/obo/HP_0012418
T32	10654-10664	Phenotype	denotes	meningitis	http://purl.obolibrary.org/obo/HP_0001287
T33	11647-11663	Phenotype	denotes	oxidative stress	http://purl.obolibrary.org/obo/HP_0025464

LitCovid-sentences

Id	Subject	Object	Predicate	Lexical cue
T773	0-15	Sentence	denotes	Acknowledgments
T774	16-129	Sentence	denotes	The authors would like to thank King Abdullah University of Science and Technology (KAUST) for financial support.
T775	131-151	Sentence	denotes	Author Contributions
T776	152-247	Sentence	denotes	A.-H.E. designed the outline of the manuscript, and offered numerous suggestions for each part.
T777	248-347	Sentence	denotes	B.G.P. contributed to Section 3 and Section 4 of this paper, and provided English editing services.
T778	348-391	Sentence	denotes	K.S. arranged and organized the references.
T779	392-511	Sentence	denotes	K.S. and K.C. designed the figures representing common NMR mechanisms and concepts, as well as the NMR pulse sequences.
T780	512-670	Sentence	denotes	R.T.M., M.J., and L.J. contributed their NMR expertise to make “An Introduction to NMR Spectroscopy” (Section 2) scientifically correct and reader accessible.
T781	671-795	Sentence	denotes	M.D. and F.A. created the figures in the Introduction and made valuable revisions for the final remarks section (Section 5).
T782	796-900	Sentence	denotes	J.I.L. did extensive research and added the information regarding NMR as it applies to studying viruses.
T783	901-994	Sentence	denotes	M.D. and J.I.L. developed and contributed to all parts, especially the final remarks section.
T784	995-1071	Sentence	denotes	All authors have read and agreed to the published version of the manuscript.
T785	1073-1080	Sentence	denotes	Funding
T786	1081-1124	Sentence	denotes	This research received no external funding.
T787	1126-1147	Sentence	denotes	Conflicts of Interest
T788	1148-1192	Sentence	denotes	The authors declare no conflict of interest.
T789	1194-1221	Sentence	denotes	Figures, Schemes and Tables
T790	1222-1279	Sentence	denotes	Scheme 1 Schematic representation of drug discovery [4].
T791	1280-1331	Sentence	denotes	Numerical data were reported from Meigs et al. [3].
T792	1332-1477	Sentence	denotes	Figure 1 Data search results for: “NMR” and “Drug design” in Scopus (blue) (www.scopus.com) and Orbit patent (orange) (www.orbit.com) databases.
T793	1478-1536	Sentence	denotes	Figure 2 The most simplified layout of an NMR experiment.
T794	1537-1579	Sentence	denotes	The NMR spectrum of ethyl acetate Table 1.
T795	1580-1632	Sentence	denotes	H chemical shift assignments is shown as an example.
T796	1633-1719	Sentence	denotes	The chemical structure and simulated 1H-NMR spectrum were created using ChemDraw 18.1.
T797	1720-1757	Sentence	denotes	Figure 3 The pulse sequence of HSQC.
T798	1758-1800	Sentence	denotes	I and S represent two heteronuclear spins.
T799	1801-1850	Sentence	denotes	The τ is (1/4J) where J is the coupling constant.
T800	1851-1927	Sentence	denotes	The thick and thin bars represent the 180° and 90° pulse respectively [142].
T801	1928-2026	Sentence	denotes	Figure 4 RF (radiofrequency) pulse causes the bulk magnetization to move to the transverse plane.
T802	2027-2300	Sentence	denotes	Over time (ms to seconds, and in extreme cases, minutes [155]), the bulk magnetization will decrease in the transverse plane, and increase in the longitudinal axis, returning to its original, equilibrium value. (A) represents T1 relaxation and (B) represents T2 relaxation.
T803	2301-2331	Sentence	denotes	Figure 5 CPMG pulse sequence.
T804	2332-2421	Sentence	denotes	First, a 90° RF pulse is applied and results in transverse magnetization in the xy plane.
T805	2422-2490	Sentence	denotes	Then a 180°y pulse is applied to re-phase the magnetization vectors.
T806	2491-2655	Sentence	denotes	After 180°y, the vectors who were faster during the dephasing are overtaken by the slower vectors, which results in re-phasing and generation of a spin-echo signal.
T807	2656-2695	Sentence	denotes	This process is repeated several times.
T808	2696-2812	Sentence	denotes	Figure 6 Underlying mechanisms of (A) Traditional High-throughput Screening, and (B) Fragment Based Drug Discovery.
T809	2813-2934	Sentence	denotes	Figure 7 Overlaid 1H-15N-HSQC for FKBP in the absence (black contours) and presence (red contours) of 2-phenylimidazole.
T810	2935-2984	Sentence	denotes	Adapted with permission from Hajduk et al. [249].
T811	2985-3051	Sentence	denotes	Figure 8 Basic layout of the different NOE effect on NMR signals.
T812	3052-3124	Sentence	denotes	Figure 9 Illustration of STD NMR (a) and WaterLOGSY (b) in drug design.
T813	3125-3171	Sentence	denotes	Copied with permission from Robson-Tull [209].
T814	3172-3241	Sentence	denotes	Figure 10 Schematic representation of the principle of the INPHARMA.
T815	3242-3390	Sentence	denotes	The inter-ligand NOEs observed between two competitive ligands A (in green) and B (in blue), which bind consecutively to the same target receptor T.
T816	3391-3424	Sentence	denotes	The figure is adapted from [284].
T817	3425-3628	Sentence	denotes	Figure 11 Visual representation of how molecules diffuse in solution from a high concentration to a low concentration across an arbitrarily defined point (x = 0) after some period of time (t = ∞) [289].
T818	3629-3813	Sentence	denotes	The red arrow indicates the direction of translational motion as the molecules (green) move from an area of higher concentration (left) to an area of lower concentration (right) [287].
T819	3814-3889	Sentence	denotes	Figure 12 Spin echo (SE) sequence, as discovered by Stejskal et al. [293].
T820	3890-4094	Sentence	denotes	G1 is the first gradient pulse applied after the first 90° pulse, and G2 is the second gradient pulse applied after the first 180° pulse. δ and ∆ are the gradient length, and diffusion time, respectively.
T821	4095-4260	Sentence	denotes	Figure 13 Representation of different in-cell NMR techniques. (A) Target-detected in-cell NMR, (B) compound-detected in-cell NMR, (C) Reporter-detected in-cell NMR.
T822	4261-4327	Sentence	denotes	The red color is the isotopically labeled component of the system.
T823	4328-4363	Sentence	denotes	Adapted with permission from [409].
T824	4364-4454	Sentence	denotes	Scheme 2 Analysis of the cost and time between different NMR methods used in drug design.
T825	4455-4905	Sentence	denotes	Meaning of some of the acronyms are listed below: SOFAST—Band-Selective Optimized Flip Angle Short Transient; NUS—Non-uniform sampling; MDD—Multidimensional Decomposition; CS—Compressed Signaling; MAX ENT—Maximum Entropy; IST—Iterative Soft Threshold; STD—Saturation Transfer Difference; PNMR—Paramagnetic NMR; ALARM—A La Assay to detect Reactive Molecules; ssNMR—Solid State NMR; FBDD—Fragment Based Drug Design; SAR—Structure Activity Relationship.
T826	4906-5039	Sentence	denotes	Table 1 Recent pharmacological studies complemented with NMR approaches for evaluating the efficacy/safety of new or existing drugs.
T827	5040-5115	Sentence	denotes	Tested Substance Evaluated Effect NMR Experiments Used in the Study Ref.
T828	5116-5286	Sentence	denotes	Isoniazid (INH) INH induces oxidative stress, disturbs energy metabolism, and causes disorders in neurotransmission and neuromodulation processes in Sprague Dawley rats.
T829	5288-5328	Sentence	denotes	1H-NMR CPMG1H,1H-TOCSY1H,13C-HSQC [178]
T830	5329-5465	Sentence	denotes	Naproxen Naproxen induces a disturbance in energy and choline metabolism, and promotes catabolism of tryptophan in Sprague Dawley rats.
T831	5467-5491	Sentence	denotes	1H-NOESYPRESAT-1D [179]
T832	5492-5775	Sentence	denotes	Cisplatin (CP) Identification of six serum (alanine, betaine, glucose, glutamine, lactate, and leucine) and eight urinary (alanine, acetate, citrate, glucose, glycine, guanidinoacetate, hippurate, and lactate) metabolites that can be used as biomarkers for cisplatin nephrotoxicity.
T833	5777-5790	Sentence	denotes	1H-NMR [180]
T834	5791-5972	Sentence	denotes	Shell of Herpetospermum caudigerum Wall (SHCW) A high dosage of SHCW causes the disturbance of energy and amino acid metabolism and induces oxidative stress in Sprague-Dawley rats.
T835	5974-6014	Sentence	denotes	1H-NMR CPMG1H,13C-HSQC1H,13C-TOCSY [86]
T836	6015-6154	Sentence	denotes	Ampicillin, Maculatin 1.1 Both antibiotics cause destabilization of membrane integrity and increase breakdown of nucleic acids in E. coli.
T837	6156-6171	Sentence	denotes	1H-31P CP [94]
T838	6172-6339	Sentence	denotes	Emodin Emodin can affect the immune response and interrupt energy metabolism (citric acid cycle) along with glutathione synthesis, which can lead to oxidative stress.
T839	6341-6390	Sentence	denotes	1H-NMR CPMG1H,1H-COSY1H,13C-HMBC1H,13C-HSQC [65]
T840	6391-6552	Sentence	denotes	“RenqingMangjue” pill (RMP) RMP can disturb the citric acid cycle in cells, and decreases levels of glutamate, glutamine and BCAAs in the plasma of Wistar rats.
T841	6554-6603	Sentence	denotes	1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H-13C HMBC [66]
T842	6604-6812	Sentence	denotes	Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h).
T843	6813-6868	Sentence	denotes	Additionally, Ptac2S may inhibit lactate dehydrogenase.
T844	6870-6920	Sentence	denotes	1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]
T845	6921-7115	Sentence	denotes	Gemcitabine-carboplatin (GC) Identification of two biomarkers (formate and acetate) that can predict a positive response in MBC (metastatic breast cancer) patients treated with GC chemotherapy.
T846	7117-7185	Sentence	denotes	1H-NMR CPMG1H JRES1H,1H-COSY1H,1H-TOCSY1H,13C-HSQC1H,13C-HMBC [137]
T847	7186-7295	Sentence	denotes	Doxorubicin (DOX)/dexrazoxane (DEX) DOX decreases ATP production and induces oxidative stress in H9C2 cells.
T848	7296-7379	Sentence	denotes	DEX counteracts those changes, having a cardioprotective effect on H9C2 cell lines.
T849	7381-7404	Sentence	denotes	1H-NOESYPRESAT-1D [67]
T850	7405-7545	Sentence	denotes	Curcumin Curcumin shows antihyperlipidemic effects on C57BL/6Slac mice by partially restoring metabolic defects induced by a high-fat diet.
T851	7546-7740	Sentence	denotes	Affected metabolic pathways include the citric acid cycle, glycolysis and gluconeogenesis, ketogenesis of BCAA, synthesis of ketone bodies and cholesterol, and choline and fatty acid metabolism.
T852	7742-7788	Sentence	denotes	1H-NOESYPRESAT-1D1H-1H TOCSY1H,13C-HSQC [136]
T853	7789-7998	Sentence	denotes	Formosanin C (FC) Formosanin C shows the ability to inhibit synthesis and methylation of DNA as well as reducing the activity of the citric acid cycle and energy metabolism in the mitochondria of HepG2 cells.
T854	8000-8013	Sentence	denotes	1H-NMR [181]
T855	8014-8114	Sentence	denotes	Melamine Melamine disrupts metabolism of glucose, nitrogen, and protein in the liver of Wistar rat.
T856	8116-8134	Sentence	denotes	1H-NMR CPMG [182]
T857	8135-8252	Sentence	denotes	Aristolochic acid (AA) Aristolochic acid causes renal lesions and a disorder in tubular reabsorption in Wistar rats.
T858	8254-8266	Sentence	denotes	1H-NMR [68]
T859	8267-8369	Sentence	denotes	Rituximab Evaluating response outcome for patients with rheumatoid arthritis, treated with rituximab.
T860	8370-8506	Sentence	denotes	Identification of metabolites changes between responders and non-responders such as succinate, taurine, lactate, pyruvate and aspartate.
T861	8508-8521	Sentence	denotes	1H-NMR [183]
T862	8522-8683	Sentence	denotes	Levetiracetam, Lamotrigine, Topiramate No distinction between metabolite profiles of serum from patients treated with levetiracetam, lamotrigine and topiramate.
T863	8684-8745	Sentence	denotes	Could not evaluate response of initial treatment of epilepsy.
T864	8747-8771	Sentence	denotes	1H-NOESYPRESAT-1D [184]
T865	8772-8973	Sentence	denotes	Hexacationic Ruthenium Metallaprism Metallaprism mainly affects lipid metabolism in A2780 (human ovarian cancer) and HEK-293 (human embryonic kidney) cells, and increases GSH levels in all cell lines.
T866	8974-9101	Sentence	denotes	In A2780cisR (cisplatin resistant A2780) cells, lipid biogenesis and glycosylation are affected by treatment with metallaprism.
T867	9103-9168	Sentence	denotes	HR-MAS:a)1D-1H NOESY-1H CPMGb)2D-1H,1H-TOCSY-1H J-resolved [138]
T868	9169-9356	Sentence	denotes	Centella asiatica extract Extract from Centella asiatica promotes glycolysis, boosts the citric acid cycle and decreases gluconeogenesis and lipid metabolism in T2DM Sprague–Dawley rats.
T869	9358-9376	Sentence	denotes	1H-NMR CPMG [185]
T870	9377-9585	Sentence	denotes	VR24, VR27 (1,3,4-thiadiazoles) VR24 and VR27 improve glycerol metabolism, decrease betaine levels, and normalize the altered level of myoinositol in serum of DMH-induced CRC (colorectal cancer) Wistar rats.
T871	9587-9605	Sentence	denotes	1H-NMR CPMG [186]
T872	9606-9796	Sentence	denotes	Xiaoyaosan Xiaoyaosan regulates energy metabolism, can play an important role in the regulation of the nervous system, and might restore the balance in gut microbiota of depressed patients.
T873	9798-9837	Sentence	denotes	1H-NMR CPMG1H,1H-COSY1H,13C-HMQC [187]
T874	9838-9978	Sentence	denotes	Sini decoction (SND) SND may restore balance in myocardial energy metabolism, and regulate the citric acid cycle and amino acid metabolism.
T875	9979-10085	Sentence	denotes	Identification of 10 biomarkers showing potential efficiency of SND administration in Sprague-Dawley rats.
T876	10087-10100	Sentence	denotes	1H-NMR [188]
T877	10101-10397	Sentence	denotes	Fu Fang Jin Jing Oral Liquid (FJJOL) with Herba Rhodiol FJJOL regulates energy metabolism of brain tissue, can affect the function of neurons abundant in GABA and glycine receptors, and may help to maintain the membrane integrity of the cells in Kunming-strain mice exposed to hypobaric hypoxia.
T878	10399-10444	Sentence	denotes	1H-NOESYPRESAT-1D1H,1H-gCOSY1H,1H-TOCSY [87]
T879	10445-10674	Sentence	denotes	Acyclovir, Pyrazinamide, Isoniazid, Sulfamethoxazole Evaluating the efficacy (determined by the concentration of a drug able to reach the therapeutic site) of four drugs in cerebrospinal fluid of tuberculous meningitis patients.
T880	10676-10710	Sentence	denotes	1H-NOESYPRESAT-1D1H,1H-COSY [189]
T881	10711-10860	Sentence	denotes	Genipin Genipin can recover energy metabolism to normal levels, and regulate methylamine and amino acid metabolisms of diabetic Sprague Dawley rats.
T882	10862-10880	Sentence	denotes	1H-NOESY-1D [190]
T883	10881-11144	Sentence	denotes	Adriamycin (ADR) Identification of seven biomarkers: trimethylamine oxide (TMAO), taurine, trimethylamine (TMA), hippurate, trigonelline, citrate and 2-oxoglutarate that can predict tumor’s (gastric adenocarcinoma) response to ADR treatment in BALB/c-nu/nu mice.
T884	11146-11170	Sentence	denotes	1H-NOESYPRESAT-1D [191]
T885	11171-11372	Sentence	denotes	Danggui/European Danggui Comparison between Danggui and European Danggui showed that Danggui has a different chemical composition and provides a better enriching effect on blood than European Danggui.
T886	11373-11436	Sentence	denotes	Identification of 18 metabolites affected by Danggui treatment.
T887	11438-11493	Sentence	denotes	1H-NMR CPMG1H-NOESYPRESAT-1D1H,1H-COSY1H,13C-HSQC [88]
T888	11494-11689	Sentence	denotes	Erythromycin Erythromycin decreases citric acid cycle activity, enhances fatty acid oxidation, causes dysfunction in amino acid metabolism, and creates oxidative stress in livers of Wistar rats.
T889	11691-11722	Sentence	denotes	1H-NMR CPMG1H-NMR BPPLED [192]
T890	11723-11903	Sentence	denotes	Fuzi/Gancao Fuzi causes a shift in energy metabolism (from aerobic respiration to anaerobic), induces membrane toxicity, and disrupts the balance of gut microbiota of Wistar rats.
T891	11904-11973	Sentence	denotes	Administrating Fuzi with Gancao diminishes the toxic effects of Fuzi.
T892	11975-11993	Sentence	denotes	1H-NOESY-1D [193]
T893	11994-12277	Sentence	denotes	Kijitsu, Tohi, Chimpi, Kippi, Seihi 1H-NMR spectra enabled the identification of three compounds (naringin, sucrose, and β-glucose), and 13C-NMR enabled the identification of eight compounds (naringin, neohesperidin, ɑ- and β-glucose, sucrose, limonene, narirutin, and synephrine).
T894	12279-12299	Sentence	denotes	1H-NMR13C-NMR [112]
T895	12300-12480	Sentence	denotes	Table 2 The names, structures, targets, FBDD optimization strategy used, biophysical techniques used, and status in clinical trials of select drugs derived from the FBDD approach.
T896	12481-12595	Sentence	denotes	Drug (Company) Target Original Fragment(s) * Advanced Molecule and Progress in Clinical Trials Techniques Used
T897	12596-12726	Sentence	denotes	Vemurafenib (Plexxikon) [224,226] BRAF-V600E Approved high-concentration biochemical fragment screening, X-ray crystallography
T898	12727-12820	Sentence	denotes	Venetoclax (AbbVie, Genetech) [227,228,229,230] BCL-2 Approved NMR, X-ray crystallography
T899	12821-12942	Sentence	denotes	Ribociclib (Novartis Europharm Limited) [231] CDK4 and 6 Information Not Available Approved Information not Available
T900	12943-13075	Sentence	denotes	PLX3397 (Plexxikon) [232,233,234] FMS, KIT, and FLT3-ITD Phase 3 X-ray crystallography, Structure Confirmed by NMR, MS, and HPLC
T901	13076-13178	Sentence	denotes	Verubecestat (Merck) [235,236] BACE1 Phase 3 NMR, X-ray crystallography, inhibition of cathepsin D
T902	13179-13285	Sentence	denotes	Onalespib (Astex) [237,238] HSP90 Phase 2 X-ray crystallography, isothermal titration calorimetry, NMR
T903	13286-13409	Sentence	denotes	AZD5099 [239,240] Topoisomerase II Phase 1 NMR, Surface Plasmon Resonance, isothermal calorimetry, X-ray cystallography
T904	13410-13496	Sentence	denotes	AT7519 [241,242,243,244] CDK 1, 2, 4, and 5 Phase 2 NMR, MS, X-ray crystallography
T905	13497-13589	Sentence	denotes	* Structures for some of the fragments are taken directly from Dan Erlanson’s blog at [245].
T906	13590-13680	Sentence	denotes	Table 3 Advantages and limitations of different NMR techniques developed in recent years.
T907	13681-13721	Sentence	denotes	NMR Technique Advantages Disadvantages
T908	13722-13879	Sentence	denotes	1D-NMR Ability to identify simple chemical compounds.High quality resolution and sensitivity for many 1D experiments.Less time consuming compared to 2D NMR.
T909	13881-14074	Sentence	denotes	Compared to 2D NMR less details can be obtained for more complex molecules.For nuclei other than 1H and 19F, relative sensitivity is fairly low—requires extra labeling to obtain better spectra.
T910	14075-14255	Sentence	denotes	2D NMR Ability to identify complex molecules and observe different interactions between the nuclei, e.g., correlations between all spins in one spin system using TOCSY experiment.
T911	14257-14317	Sentence	denotes	Requires long times to obtain a proper spectra (up to days).
T912	14318-14378	Sentence	denotes	Ultrafast 2D NMR Greatly reduces time to obtain 2D spectra.
T913	14380-14400	Sentence	denotes	Reduced sensitivity.
T914	14401-14456	Sentence	denotes	SOFAST Significantly reduces acquisition time of HMQC.
T915	14458-14483	Sentence	denotes	Relatively low resolution
T916	14484-14563	Sentence	denotes	NUS Lowers the time of measurement while keeping the same level of resolution.
T917	14565-14666	Sentence	denotes	Requires use of reconstruction algorithms since missing data points can lead to artifacts in spectra.
T918	14667-14797	Sentence	denotes	MDD Multidimensional data are “broken” to one dimensional, which are easier to analyze.Ability to resolve overlapping resonances.
T919	14800-14883	Sentence	denotes	Data must be (approximately) symmetrical (Lorentzian shape) to obtain good spectra.
T920	14884-14924	Sentence	denotes	CS Good reconstruction of weaker peaks.
T921	14926-14983	Sentence	denotes	Large computational costs, low performance on noisy data.
T922	14984-15035	Sentence	denotes	MAX ENT Significant reduction in acquisition time.
T923	15037-15124	Sentence	denotes	Nominally Lorentzian peak shapes may be distorted, and peak intensities may be altered.
T924	15125-15173	Sentence	denotes	IST Greatly reduced time to obtain NMR spectra.
T925	15175-15224	Sentence	denotes	Requires a grid of uniformly sampled data points.
T926	15225-15331	Sentence	denotes	FBDD Often makes stronger binding ligands from weakly binding fragments.Less time and resource intensive.
T927	15333-15394	Sentence	denotes	Can be used only for small fragments of compound of interest.
T928	15395-15447	Sentence	denotes	SAR Direct observation of target binding to ligand.
T929	15448-15494	Sentence	denotes	Several types of NMR experiments are possible.
T930	15496-15599	Sentence	denotes	Inability to distinguish binding modes, difficult to gage the “true” binding site of ligand to protein.
T931	15600-15709	Sentence	denotes	STD Only requires a small amount of sample.Highly reproducible.Allows direct observations of ligand binding.
T932	15711-15785	Sentence	denotes	Only works for ligands with low binding affinity (fast chemical exchange).
T933	15786-15825	Sentence	denotes	Inability to distinguish binding modes.
T934	15826-15902	Sentence	denotes	In cell NMR In vivo studies are possible, can focus on specific cell parts.
T935	15904-15948	Sentence	denotes	Special labeling techniques may be required.
T936	15949-15994	Sentence	denotes	Spectra may be more challenging to interpret.
T937	15995-16164	Sentence	denotes	In silico + NMR Can model protein drug interactions, helps speed up and reduce cost of drug delivery Protein models need to be validated through experimental approach.
T938	16165-16308	Sentence	denotes	PNMR Can observe proteins interacting with metal ions, long observation distance (10-25 angstroms) between paramagnetic left and nearby atoms.
T939	16310-16351	Sentence	denotes	Paramagnetic left required in the system.
T940	16352-16462	Sentence	denotes	ALARM NMR Elimination of false positives from HTS methods It requires synthesis of human La antigen protein.
T941	16463-16626	Sentence	denotes	ssNMR Enables the characterization of a chemical compound in a solid-state form such as a tablet/pill.Provides insight into the physical properties of a compound.
T942	16628-16715	Sentence	denotes	Significant broadening of the spectral lineshapes due to anisotropic spin interactions.
T943	16716-16804	Sentence	denotes	Relaxation editing Noticeable difference in spectra of binding and non-binding ligands.
T944	16806-16874	Sentence	denotes	Sets the lower limit of time for which experiments can be performed.

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