Unfortunately, in the real world, when working with NMR spectroscopy, we are mainly forced to choose between high or low precision data (Scheme 2) with fixed available instrument times. Scheme 2 can be useful, when choosing NMR technique and/or method/approaches in drug studies. It shows the general representation of different NMR techniques and method/approaches in cost-time matrix, bearing in mind that the exact position in the matrix can be influenced by the environmental conditions, pulse sequence and sample preparation (e.g., concentration). Regarding, NMR methods/approaches, the exact position depends on the choice of proper NMR technique. For the purposes of Scheme 2, the 2D techniques were chosen as described in the practical examples. Nevertheless, with relatively short times and at low cost, we can acquire numerous data sets and therefore the low precision can be partially compensated for by statistical analysis.