From another perspective, one can further optimize the process of obtaining spectra by using different methods of measurements. One of these, called SOFAST, helps to reduce the delay between scans resulting in lowering acquisition time for 2D experiments such as HMQC utilizing 1H,15N or 1H,13C [117,446,447]. The basic principle of this method is to use selective 1H pulses that will excite only a small portion of the available nuclei pool, while the unperturbed spins provide a magnetization “heat sink” thus improving the spin-lattice relaxation (T1) rate via dipolar interactions [446]. These methods can be highly efficient when studying drug binding and molecular interactions [117].