A Phase II Randomized Placebo-Controlled Trial of Omega-3 Fatty Acids for the Treatment of Acute Lung Injury. Stapleton et al., 2011 [223] Adults within 48 h of ARI onsetRCT EPA (9.75 g) + DHA (6.75 g) daily Not reduction of biomarkers of pulmonary or systemic inflammation in patients with ALI.