PMC:7589163 / 78071-81148 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T344","span":{"begin":63,"end":71},"obj":"Body_part"},{"id":"T345","span":{"begin":84,"end":107},"obj":"Body_part"},{"id":"T346","span":{"begin":488,"end":493},"obj":"Body_part"},{"id":"T347","span":{"begin":562,"end":575},"obj":"Body_part"},{"id":"T348","span":{"begin":654,"end":659},"obj":"Body_part"},{"id":"T349","span":{"begin":673,"end":681},"obj":"Body_part"},{"id":"T350","span":{"begin":763,"end":786},"obj":"Body_part"},{"id":"T351","span":{"begin":958,"end":963},"obj":"Body_part"},{"id":"T352","span":{"begin":1013,"end":1035},"obj":"Body_part"},{"id":"T353","span":{"begin":1214,"end":1219},"obj":"Body_part"},{"id":"T354","span":{"begin":1487,"end":1492},"obj":"Body_part"},{"id":"T355","span":{"begin":1535,"end":1558},"obj":"Body_part"},{"id":"T356","span":{"begin":1780,"end":1785},"obj":"Body_part"},{"id":"T357","span":{"begin":1792,"end":1797},"obj":"Body_part"},{"id":"T358","span":{"begin":2065,"end":2070},"obj":"Body_part"},{"id":"T359","span":{"begin":2084,"end":2089},"obj":"Body_part"},{"id":"T360","span":{"begin":2138,"end":2161},"obj":"Body_part"},{"id":"T361","span":{"begin":2360,"end":2365},"obj":"Body_part"},{"id":"T362","span":{"begin":2418,"end":2422},"obj":"Body_part"},{"id":"T363","span":{"begin":2579,"end":2583},"obj":"Body_part"},{"id":"T364","span":{"begin":2651,"end":2656},"obj":"Body_part"},{"id":"T365","span":{"begin":2679,"end":2687},"obj":"Body_part"},{"id":"T366","span":{"begin":2791,"end":2799},"obj":"Body_part"},{"id":"T367","span":{"begin":2898,"end":2921},"obj":"Body_part"},{"id":"T368","span":{"begin":2939,"end":2962},"obj":"Body_part"},{"id":"T369","span":{"begin":3049,"end":3066},"obj":"Body_part"}],"attributes":[{"id":"A344","pred":"fma_id","subj":"T344","obj":"http://purl.org/sig/ont/fma/fma292381"},{"id":"A345","pred":"fma_id","subj":"T345","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A346","pred":"fma_id","subj":"T346","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma76497"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A349","pred":"fma_id","subj":"T349","obj":"http://purl.org/sig/ont/fma/fma292381"},{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A352","pred":"fma_id","subj":"T352","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A353","pred":"fma_id","subj":"T353","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A354","pred":"fma_id","subj":"T354","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A355","pred":"fma_id","subj":"T355","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A356","pred":"fma_id","subj":"T356","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A357","pred":"fma_id","subj":"T357","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A358","pred":"fma_id","subj":"T358","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A359","pred":"fma_id","subj":"T359","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A360","pred":"fma_id","subj":"T360","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A361","pred":"fma_id","subj":"T361","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma292381"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma292381"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma45662"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma265130"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T144","span":{"begin":84,"end":107},"obj":"Body_part"},{"id":"T145","span":{"begin":90,"end":107},"obj":"Body_part"},{"id":"T146","span":{"begin":488,"end":493},"obj":"Body_part"},{"id":"T147","span":{"begin":654,"end":659},"obj":"Body_part"},{"id":"T148","span":{"begin":763,"end":786},"obj":"Body_part"},{"id":"T149","span":{"begin":769,"end":786},"obj":"Body_part"},{"id":"T150","span":{"begin":958,"end":963},"obj":"Body_part"},{"id":"T151","span":{"begin":1013,"end":1035},"obj":"Body_part"},{"id":"T152","span":{"begin":1214,"end":1219},"obj":"Body_part"},{"id":"T153","span":{"begin":1487,"end":1492},"obj":"Body_part"},{"id":"T154","span":{"begin":1535,"end":1558},"obj":"Body_part"},{"id":"T155","span":{"begin":1541,"end":1558},"obj":"Body_part"},{"id":"T156","span":{"begin":1780,"end":1785},"obj":"Body_part"},{"id":"T157","span":{"begin":1792,"end":1797},"obj":"Body_part"},{"id":"T158","span":{"begin":2065,"end":2070},"obj":"Body_part"},{"id":"T159","span":{"begin":2084,"end":2089},"obj":"Body_part"},{"id":"T160","span":{"begin":2138,"end":2161},"obj":"Body_part"},{"id":"T161","span":{"begin":2144,"end":2161},"obj":"Body_part"},{"id":"T162","span":{"begin":2360,"end":2365},"obj":"Body_part"},{"id":"T163","span":{"begin":2418,"end":2422},"obj":"Body_part"},{"id":"T164","span":{"begin":2579,"end":2583},"obj":"Body_part"},{"id":"T165","span":{"begin":2651,"end":2656},"obj":"Body_part"},{"id":"T166","span":{"begin":2898,"end":2921},"obj":"Body_part"},{"id":"T167","span":{"begin":2904,"end":2921},"obj":"Body_part"},{"id":"T168","span":{"begin":2939,"end":2962},"obj":"Body_part"},{"id":"T169","span":{"begin":2945,"end":2962},"obj":"Body_part"},{"id":"T170","span":{"begin":3049,"end":3066},"obj":"Body_part"}],"attributes":[{"id":"A144","pred":"uberon_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A145","pred":"uberon_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A146","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A147","pred":"uberon_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A148","pred":"uberon_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A149","pred":"uberon_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A151","pred":"uberon_id","subj":"T151","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A152","pred":"uberon_id","subj":"T152","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A153","pred":"uberon_id","subj":"T153","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A154","pred":"uberon_id","subj":"T154","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A155","pred":"uberon_id","subj":"T155","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A156","pred":"uberon_id","subj":"T156","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A157","pred":"uberon_id","subj":"T157","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A158","pred":"uberon_id","subj":"T158","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A159","pred":"uberon_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A160","pred":"uberon_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A161","pred":"uberon_id","subj":"T161","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A162","pred":"uberon_id","subj":"T162","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A163","pred":"uberon_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A164","pred":"uberon_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A165","pred":"uberon_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A166","pred":"uberon_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A167","pred":"uberon_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A168","pred":"uberon_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/UBERON_0001558"},{"id":"A169","pred":"uberon_id","subj":"T169","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"id":"A170","pred":"uberon_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T339","span":{"begin":90,"end":118},"obj":"Disease"},{"id":"T340","span":{"begin":266,"end":287},"obj":"Disease"},{"id":"T341","span":{"begin":278,"end":287},"obj":"Disease"},{"id":"T342","span":{"begin":562,"end":575},"obj":"Disease"},{"id":"T343","span":{"begin":700,"end":710},"obj":"Disease"},{"id":"T344","span":{"begin":769,"end":797},"obj":"Disease"},{"id":"T345","span":{"begin":813,"end":819},"obj":"Disease"},{"id":"T346","span":{"begin":1036,"end":1045},"obj":"Disease"},{"id":"T347","span":{"begin":1320,"end":1341},"obj":"Disease"},{"id":"T348","span":{"begin":1541,"end":1572},"obj":"Disease"},{"id":"T349","span":{"begin":1836,"end":1857},"obj":"Disease"},{"id":"T350","span":{"begin":1848,"end":1857},"obj":"Disease"},{"id":"T351","span":{"begin":2144,"end":2175},"obj":"Disease"},{"id":"T352","span":{"begin":2458,"end":2479},"obj":"Disease"},{"id":"T353","span":{"begin":2470,"end":2479},"obj":"Disease"},{"id":"T354","span":{"begin":2805,"end":2814},"obj":"Disease"},{"id":"T355","span":{"begin":2866,"end":2875},"obj":"Disease"},{"id":"T356","span":{"begin":2904,"end":2931},"obj":"Disease"},{"id":"T357","span":{"begin":2922,"end":2931},"obj":"Disease"},{"id":"T358","span":{"begin":2945,"end":2972},"obj":"Disease"},{"id":"T359","span":{"begin":2963,"end":2972},"obj":"Disease"},{"id":"T360","span":{"begin":3049,"end":3076},"obj":"Disease"},{"id":"T361","span":{"begin":3067,"end":3076},"obj":"Disease"}],"attributes":[{"id":"A339","pred":"mondo_id","subj":"T339","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A340","pred":"mondo_id","subj":"T340","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A341","pred":"mondo_id","subj":"T341","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A342","pred":"mondo_id","subj":"T342","obj":"http://purl.obolibrary.org/obo/MONDO_0002465"},{"id":"A343","pred":"mondo_id","subj":"T343","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A344","pred":"mondo_id","subj":"T344","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A345","pred":"mondo_id","subj":"T345","obj":"http://purl.obolibrary.org/obo/MONDO_0004979"},{"id":"A346","pred":"mondo_id","subj":"T346","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A347","pred":"mondo_id","subj":"T347","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A348","pred":"mondo_id","subj":"T348","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A349","pred":"mondo_id","subj":"T349","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A350","pred":"mondo_id","subj":"T350","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A351","pred":"mondo_id","subj":"T351","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A352","pred":"mondo_id","subj":"T352","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A353","pred":"mondo_id","subj":"T353","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A354","pred":"mondo_id","subj":"T354","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A355","pred":"mondo_id","subj":"T355","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A356","pred":"mondo_id","subj":"T356","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A357","pred":"mondo_id","subj":"T357","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A358","pred":"mondo_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A359","pred":"mondo_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A360","pred":"mondo_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A361","pred":"mondo_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

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Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

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org/obo/CHEBI_27300"},{"id":"A19083","pred":"chebi_id","subj":"T27723","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A57308","pred":"chebi_id","subj":"T17404","obj":"http://purl.obolibrary.org/obo/CHEBI_89324"},{"id":"A13624","pred":"chebi_id","subj":"T66082","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A66130","pred":"chebi_id","subj":"T57364","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A65389","pred":"chebi_id","subj":"T63214","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T200","span":{"begin":84,"end":118},"obj":"Phenotype"},{"id":"T201","span":{"begin":216,"end":236},"obj":"Phenotype"},{"id":"T202","span":{"begin":266,"end":287},"obj":"Phenotype"},{"id":"T203","span":{"begin":494,"end":514},"obj":"Phenotype"},{"id":"T204","span":{"begin":562,"end":575},"obj":"Phenotype"},{"id":"T205","span":{"begin":763,"end":797},"obj":"Phenotype"},{"id":"T206","span":{"begin":799,"end":807},"obj":"Phenotype"},{"id":"T207","span":{"begin":813,"end":819},"obj":"Phenotype"},{"id":"T208","span":{"begin":1013,"end":1045},"obj":"Phenotype"},{"id":"T209","span":{"begin":1535,"end":1569},"obj":"Phenotype"},{"id":"T210","span":{"begin":1751,"end":1771},"obj":"Phenotype"},{"id":"T211","span":{"begin":1836,"end":1857},"obj":"Phenotype"},{"id":"T212","span":{"begin":2106,"end":2126},"obj":"Phenotype"},{"id":"T213","span":{"begin":2138,"end":2172},"obj":"Phenotype"},{"id":"T214","span":{"begin":2458,"end":2479},"obj":"Phenotype"},{"id":"T215","span":{"begin":2688,"end":2708},"obj":"Phenotype"},{"id":"T216","span":{"begin":2805,"end":2814},"obj":"Phenotype"},{"id":"T217","span":{"begin":2866,"end":2875},"obj":"Phenotype"},{"id":"T218","span":{"begin":2898,"end":2931},"obj":"Phenotype"},{"id":"T219","span":{"begin":2939,"end":2972},"obj":"Phenotype"},{"id":"T220","span":{"begin":3049,"end":3076},"obj":"Phenotype"}],"attributes":[{"id":"A200","pred":"hp_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A201","pred":"hp_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/HP_0100512"},{"id":"A202","pred":"hp_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A203","pred":"hp_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/HP_0100512"},{"id":"A204","pred":"hp_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/HP_0011950"},{"id":"A205","pred":"hp_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A206","pred":"hp_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/HP_0030828"},{"id":"A207","pred":"hp_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A208","pred":"hp_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A209","pred":"hp_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A210","pred":"hp_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/HP_0100512"},{"id":"A211","pred":"hp_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A212","pred":"hp_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/HP_0100512"},{"id":"A213","pred":"hp_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A214","pred":"hp_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A215","pred":"hp_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/HP_0006532"},{"id":"A216","pred":"hp_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A217","pred":"hp_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A218","pred":"hp_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A219","pred":"hp_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/HP_0002783"},{"id":"A220","pred":"hp_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/HP_0011947"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T500","span":{"begin":0,"end":137},"obj":"Sentence"},{"id":"T501","span":{"begin":138,"end":188},"obj":"Sentence"},{"id":"T502","span":{"begin":189,"end":306},"obj":"Sentence"},{"id":"T503","span":{"begin":308,"end":482},"obj":"Sentence"},{"id":"T504","span":{"begin":483,"end":576},"obj":"Sentence"},{"id":"T505","span":{"begin":578,"end":711},"obj":"Sentence"},{"id":"T506","span":{"begin":712,"end":833},"obj":"Sentence"},{"id":"T507","span":{"begin":835,"end":952},"obj":"Sentence"},{"id":"T508","span":{"begin":953,"end":1065},"obj":"Sentence"},{"id":"T509","span":{"begin":1067,"end":1230},"obj":"Sentence"},{"id":"T510","span":{"begin":1231,"end":1342},"obj":"Sentence"},{"id":"T511","span":{"begin":1344,"end":1481},"obj":"Sentence"},{"id":"T512","span":{"begin":1482,"end":1611},"obj":"Sentence"},{"id":"T513","span":{"begin":1613,"end":1786},"obj":"Sentence"},{"id":"T514","span":{"begin":1787,"end":1906},"obj":"Sentence"},{"id":"T515","span":{"begin":1908,"end":2090},"obj":"Sentence"},{"id":"T516","span":{"begin":2091,"end":2185},"obj":"Sentence"},{"id":"T517","span":{"begin":2187,"end":2350},"obj":"Sentence"},{"id":"T518","span":{"begin":2351,"end":2491},"obj":"Sentence"},{"id":"T519","span":{"begin":2493,"end":2658},"obj":"Sentence"},{"id":"T520","span":{"begin":2659,"end":2709},"obj":"Sentence"},{"id":"T521","span":{"begin":2710,"end":2750},"obj":"Sentence"},{"id":"T522","span":{"begin":2752,"end":2885},"obj":"Sentence"},{"id":"T523","span":{"begin":2886,"end":3077},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}

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5 Levels of 25-hydroxyvitamin D during pregnancy and in neonates and risk of lower respiratory tract infections (LRTI) in infancy.\nStudy Authors Country Study Population Results\nAssociation of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Karatekin et al., 2009 [145] Turkey 25 newborns with LRTI admitted to NICU vs. healthy controls Significantly lower vitamin D levels in affected newborns than in controls.\nCord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Belderbos et al., 2011 [146] Netherlands 156 healthy newborns Lower cord blood vitamin D in neonates who developed RSV infections.\nMaternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring. Morales et al., 2012 [147] Spain 1724 pregnant women Decreased LRTI in offspring of mothers with higher vitamin D.\nCord blood 25-hydroxyvitamin D levels and the risk of acute lowerrespiratory tract infection in early childhood. Mohameet al., 2013 [148] Egypt 206 healthy newborns Increased risk of developing ALRIs in the first 2 years of life in newborns with lower cord blood vitamin D.\nProspective study of maternal mid-pregnancy 25-hydroxyvitamin D level and earlychildhood respiratory disorders. Magnus et al., 2013 [149] Norway Pregnant women Reduced risk of LRTI in offspring by age 36 months when maternal vitamin D was higher.\nCord blood 25(OH)D levels and the subsequent risk of lower respiratory tract infections in early childhood: the Ulm birth cohort. Luczynska et al., 2014 [150] Germany 777 healthy newborns Increased risk of developing LRTIs in the first year of life in infants with vitamin D deficiency in cord blood.\nCord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory. Binks et al., 2016[151] Australia 109 mother-infant pairs Higher risk of hospitalization for ALRI in pairs with lower vitamin D levels in pregnancy, cord blood and infants’ blood.\nAssociation of vitamin D deficiency with acute lower respiratory tract infections in newborns. Dinlen et al., 2016[152] Turkey 30 newborns with ALRI and their mothers vs. healthy control pairs Lower vitamin D levels in ALRI group than in healthy controls.\nLow cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy. Lai et al., 2017[153] Taiwan 122 mother-infant pairs Higher risk of RTI and poorer lung function in infants with lower vitamin D levels (maternal and cord blood).\nVitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators. El-Kassas et al., 2019[154] Egypt 33 neonates with pneumonia vs. healthy controls Lower levels of vitamin D in pneumonia patients.\nALRI, acute lower respiratory tract infection; LRTI, lower respiratory tract infection; NICU, neonatal intensive care unit; RSV, respiratory syncytial virus; RTI, respiratory tract infection."}