Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial.  Fowler AA 2019 [72]  AdultsRCT  Vitamin C (IV 50 mg/kg every 6 h for 96 h)  Significant reduction in 28-day all-cause mortality (p = 0.03), and with significantly increased ICU-free days to day 28 (p = 0.03) and hospital-free days to day 60 (p = 0.04).