PMC:7589163 / 35056-37815
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T209 | 1916-1929 | Body_part | denotes | bronchiolitis | http://purl.org/sig/ont/fma/fma76497 |
| T210 | 2204-2221 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T80 | 2204-2221 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T142 | 360-369 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T143 | 533-542 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T144 | 610-633 | Disease | denotes | recurrence of pneumonia | http://purl.obolibrary.org/obo/MONDO_0005936 |
| T145 | 624-633 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T146 | 840-849 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T147 | 1064-1073 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T148 | 1675-1684 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T149 | 1916-1929 | Disease | denotes | bronchiolitis | http://purl.obolibrary.org/obo/MONDO_0002465 |
| T150 | 2204-2232 | Disease | denotes | respiratory tract infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T151 | 2394-2403 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T389 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T390 | 41-42 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T391 | 279-280 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T392 | 416-417 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T393 | 562-563 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T394 | 602-603 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T395 | 664-665 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T396 | 770-771 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T397 | 952-953 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T398 | 1129-1130 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T399 | 1370-1371 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T400 | 1594-1595 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T401 | 1763-1764 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T402 | 1865-1866 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T403 | 1916-1929 | http://purl.obolibrary.org/obo/UBERON_0002186 | denotes | bronchiolitis |
| T404 | 2020-2021 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T405 | 2137-2138 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T406 | 2480-2481 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T407 | 2555-2556 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T408 | 2631-2632 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T542 | 65-74 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T543 | 65-72 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T544 | 311-320 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T545 | 311-318 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T546 | 463-468 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T547 | 681-690 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T548 | 681-688 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T549 | 783-792 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T550 | 783-790 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T551 | 880-889 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T552 | 880-887 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T553 | 1094-1099 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T554 | 1220-1225 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T555 | 1392-1401 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T556 | 1392-1399 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T557 | 1783-1793 | Chemical | denotes | antibiotic | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T558 | 1818-1823 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T559 | 1965-1974 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T560 | 1965-1972 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T561 | 2180-2189 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T562 | 2180-2187 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T563 | 2601-2610 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T564 | 2601-2608 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T76 | 360-369 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T77 | 610-633 | Phenotype | denotes | recurrence of pneumonia | http://purl.obolibrary.org/obo/HP_0006532 |
| T78 | 840-849 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T79 | 1064-1073 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T80 | 1173-1193 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T81 | 1675-1684 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T82 | 1916-1929 | Phenotype | denotes | bronchiolitis | http://purl.obolibrary.org/obo/HP_0011950 |
| T83 | 2204-2232 | Phenotype | denotes | respiratory tract infections | http://purl.obolibrary.org/obo/HP_0011947 |
| T84 | 2394-2403 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T224 | 0-214 | Sentence | denotes | A few studies investigated the effect of a short-term, high-dose vitamin D supplementation, which is the most practical administration scheme, but mostly found that these regimens were not significantly beneficial. |
| T225 | 215-549 | Sentence | denotes | Manaseki-Holland and colleagues evaluated the administration of a single high-dose (100,000 IU) vitamin D supplementation in addition to routine pneumonia treatment in children in Kabul, and evidenced a lower risk of recurrence in the intervention group but no difference in the time needed to recovery from the first infection [155]. |
| T226 | 550-697 | Sentence | denotes | Furthermre, a smaller study from Pakistan described a lower recurrence of pneumonia in children supplemented with a single dose of vitamin D [160]. |
| T227 | 698-1100 | Sentence | denotes | Similar trials from Choudhary et al. [157] and Gupta et al. [165] tried a short-term vitamin D supplementation in Indian children with severe pneumonia: the first study supplemented vitamin D (1,000–2,000 UI/day) for 5 days, and the second 100,000 UI in a single dose; in both studies the authors did not evidence significant beneficial effects in the resolution of pneumonia in the intervention group. |
| T228 | 1101-1266 | Sentence | denotes | Gupta et al. evidenced only a slightly quicker resolution of the severe respiratory distress (1 h) in the intervention group, which might not be clinically relevant. |
| T229 | 1267-1593 | Sentence | denotes | Similar results were reached in 2017 by Somnath and colleagues [166], who investigated the efficacy of a single high dose of vitamin D in the treatment of children hospitalized with ALRI, and found it did not influence the duration of hospital stay nor the secondary outcomes (mortality, PICU admissions, complications, etc.). |
| T230 | 1594-1830 | Sentence | denotes | A supplementation of 50,000 IU/day for 2 days was tried in Iran in children with pneumonia and it did not influence the severity of symptoms, however the study reported a lower duration of antibiotic use in the intervention group [166]. |
| T231 | 1831-2120 | Sentence | denotes | Contrasting evidence was found in a 2015 Egyptian trial on children hospitalized for bronchiolitis [161], where the administration of vitamin D 100 IU/kg/day for 5 days was associated with a significant improvement in the duration of hospitalization and time taken to improve oral feeding. |
| T232 | 2121-2523 | Sentence | denotes | The efficacy of a high dose, short-term supplementation of vitamin D in preventing respiratory tract infections was also analyzed in 2012 by Manaseki-Holland and colleagues [157], who found 100,000 IU supplementation every 3 months ineffective in reducing the incidence of pneumonia, and later in 2019 by Singh et al. [169], who achieved similar results with a 300,000 IU supplementation every 3 month. |
| T233 | 2524-2759 | Sentence | denotes | Overall, the administration of a bolus dose or short-term supplementation of vitamin D did not demonstrate a consistent efficacy in treating nor in preventing LRTI [171], although there is, at times, conflicting evidence on the matter. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 950 | 383-391 | Species | denotes | children | Tax:9606 |
| 951 | 637-645 | Species | denotes | children | Tax:9606 |
| 952 | 819-827 | Species | denotes | children | Tax:9606 |
| 953 | 1422-1430 | Species | denotes | children | Tax:9606 |
| 954 | 1661-1669 | Species | denotes | children | Tax:9606 |
| 955 | 1890-1898 | Species | denotes | children | Tax:9606 |
| 956 | 1173-1184 | Species | denotes | respiratory | Tax:12814 |
| 957 | 65-74 | Chemical | denotes | vitamin D | MESH:D014807 |
| 958 | 311-320 | Chemical | denotes | vitamin D | MESH:D014807 |
| 959 | 681-690 | Chemical | denotes | vitamin D | MESH:D014807 |
| 960 | 783-792 | Chemical | denotes | vitamin D | MESH:D014807 |
| 961 | 880-889 | Chemical | denotes | vitamin D | MESH:D014807 |
| 962 | 1392-1401 | Chemical | denotes | vitamin D | MESH:D014807 |
| 963 | 1965-1974 | Chemical | denotes | vitamin D | MESH:D014807 |
| 964 | 2180-2189 | Chemical | denotes | vitamin D | MESH:D014807 |
| 965 | 2601-2610 | Chemical | denotes | vitamin D | MESH:D014807 |
| 966 | 360-369 | Disease | denotes | pneumonia | MESH:D011014 |
| 967 | 533-542 | Disease | denotes | infection | MESH:D007239 |
| 968 | 624-633 | Disease | denotes | pneumonia | MESH:D011014 |
| 969 | 840-849 | Disease | denotes | pneumonia | MESH:D011014 |
| 970 | 1064-1073 | Disease | denotes | pneumonia | MESH:D011014 |
| 971 | 1544-1553 | Disease | denotes | mortality | MESH:D003643 |
| 972 | 1675-1684 | Disease | denotes | pneumonia | MESH:D011014 |
| 973 | 1916-1929 | Disease | denotes | bronchiolitis | MESH:D001988 |
| 974 | 2204-2232 | Disease | denotes | respiratory tract infections | MESH:D012141 |
| 975 | 2394-2403 | Disease | denotes | pneumonia | MESH:D011014 |